MnPt@metal organic framework nanozyme with photothermal/catalytic dual-strategy enhances Zn2+-mediated immunotherapy through activating pyroptosis and cGAS-STING pathway
Abstract
Zinc ions (Zn2+) can induce immune response through activating pyroptosis and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, and disrupting the intracellular redox balance is an important strategy for enhancing Zn2+-driven immunotherapy. Herein, using bimetallic manganese platinum (MnPt) nanozyme as the core, a multifunctional MnPt@ZIF-8/β-Lap@F-127 nanozyme with multi-enzyme activity was developed by coating metal-organic framework (ZIF-8), carrying β-Lapachone (β-Lap) and modifying F-127 and the Zn2+-induced immunotherapy was enhanced through photothermal/catalytic dual-strategy. The MnPt@ZIF-8/β-Lap@F-127 nanozyme has the glutathione peroxidase/peroxidase/catalase-like activity, and the photothermal and photoacoustic imaging properties. Under acidic microenvironment, the MnPt@ZIF-8/β-Lap@F-127 nanozyme was degraded, and the Zn2+ and β-Lap were released. By producing a large amount of reactive oxygen species, the MnPt@ZIF-8/β-Lap@F-127 nanozyme induced apoptosis and pyroptosis, and activated the cGAS-STING pathway. Under the dual action of photothermal/catalytic, the mitochondrial function was destroyed and the damage-associated molecular patterns were released, effectively triggering the immunogenic cell death. By improving the immune cells infiltration and pro-inflammatory factors level and reducing the immunosuppressive cells proportion, the MnPt@ZIF-8/β-Lap@F-127 nanozyme greatly inhibited the primary tumor growth and lung metastasis, which demonstrated that the MnPt@ZIF-8/β-Lap@F-127 nanozyme remodeled the immune microenvironment and enhanced the Zn2+-induced immunotherapy.
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BibTeX
@article{li2026mnptmetal,
title = {{MnPt@metal organic framework nanozyme with photothermal/catalytic dual-strategy enhances Zn2+-mediated immunotherapy through activating pyroptosis and cGAS-STING pathway}},
author = {Zekai Li and Qi Zhao and Liye Wang and Zhou Shen and Feng Liu and Jiamei Ma and Lining Zhao and Xiaoping Yin and Leyong Zeng},
journal = {Regenerative Biomaterials},
year = {2026},
month = sep,
doi = {10.1093/rb/rbag210},
url = {https://doi.org/10.1093/rb/rbag210},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - MnPt@metal organic framework nanozyme with photothermal/catalytic dual-strategy enhances Zn2+-mediated immunotherapy through activating pyroptosis and cGAS-STING pathway
AU - Zekai Li
AU - Qi Zhao
AU - Liye Wang
AU - Zhou Shen
AU - Feng Liu
AU - Jiamei Ma
AU - Lining Zhao
AU - Xiaoping Yin
AU - Leyong Zeng
PY - 2026
DA - 2026/09/21
JO - Regenerative Biomaterials
DO - 10.1093/rb/rbag210
UR - https://doi.org/10.1093/rb/rbag210
AB - Zinc ions (Zn2+) can induce immune response through activating pyroptosis and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, and disrupting the intracellular redox balance is an important strategy for enhancing Zn2+-driven immunotherapy. Herein, using bimetallic manganese platinum (MnPt) nanozyme as the core, a multifunctional MnPt@ZIF-8/β-Lap@F-127 nanozyme with multi-enzyme activity was developed by coating metal-organic framework (ZIF-8), carrying β-Lapachone (β-Lap) and modifying F-127 and the Zn2+-induced immunotherapy was enhanced through photothermal/catalytic dual-strategy. The MnPt@ZIF-8/β-Lap@F-127 nanozyme has the glutathione peroxidase/peroxidase/catalase-like activity, and the photothermal and photoacoustic imaging properties. Under acidic microenvironment, the MnPt@ZIF-8/β-Lap@F-127 nanozyme was degraded, and the Zn2+ and β-Lap were released. By producing a large amount of reactive oxygen species, the MnPt@ZIF-8/β-Lap@F-127 nanozyme induced apoptosis and pyroptosis, and activated the cGAS-STING pathway. Under the dual action of photothermal/catalytic, the mitochondrial function was destroyed and the damage-associated molecular patterns were released, effectively triggering the immunogenic cell death. By improving the immune cells infiltration and pro-inflammatory factors level and reducing the immunosuppressive cells proportion, the MnPt@ZIF-8/β-Lap@F-127 nanozyme greatly inhibited the primary tumor growth and lung metastasis, which demonstrated that the MnPt@ZIF-8/β-Lap@F-127 nanozyme remodeled the immune microenvironment and enhanced the Zn2+-induced immunotherapy.
SN - 2056-3418
SN - 2056-3426
ER -