Potential role of platelet-derived growth factor D in atherosclerotic cardiovascular disease risk

Abstract

A considerable residual cardiovascular risk persists despite contemporary therapies, highlighting the urgent need to identify potential targets for atherosclerotic cardiovascular disease (ASCVD) onset and progression. Accumulating evidence suggests that platelet-derived growth factor D (PDGFD) may be involved in the development of ASCVD. Herein, we leveraged 20-year longitudinal data from the Chinese Multi-provincial Cohort Study-Proteomics Project, with up to four repeated PDGFD measurements per participant, to estimate the serum PDGFD-ASCVD association. We then emulated the effectiveness of hypothetical reductions in PDGFD serum levels on ASCVD prevention. Our findings suggest that elevated circulating PDGFD levels are associated with higher ASCVD risk and that hypothetical PDGFD-lowering strategies may be associated with reduced long-term ASCVD risk, with an estimated absolute risk reduction of up to approximately 9% under the most intensive intervention scenario. We anticipate that these findings may motivate further investigation of PDGFD-lowering strategies as a potential approach for ASCVD risk reduction.

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Cite

BibTeX RIS

BibTeX

@article{deng2026potential,
  title = {{Potential role of platelet-derived growth factor D in atherosclerotic cardiovascular disease risk}},
  author = {Xuan Deng and Zhao Yang and Pingping Jia and Yan Liu and Yuhan Zhang and Qiuju Deng and Na Yang and Yongchen Hao and Lizhen Han and Jiayi Sun and Wenting Lu and Xueting Sun and Yue Qi and Jing Liu},
  journal = {iScience},
  year = {2026},
  month = oct,
  doi = {10.1016/j.isci.2026.117864},
  url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03247-5},
  note = {CC BY-NC 4.0},
}

RIS

TY  - JOUR
TI  - Potential role of platelet-derived growth factor D in atherosclerotic cardiovascular disease risk
AU  - Xuan Deng
AU  - Zhao Yang
AU  - Pingping Jia
AU  - Yan Liu
AU  - Yuhan Zhang
AU  - Qiuju Deng
AU  - Na Yang
AU  - Yongchen Hao
AU  - Lizhen Han
AU  - Jiayi Sun
AU  - Wenting Lu
AU  - Xueting Sun
AU  - Yue Qi
AU  - Jing Liu
PY  - 2026
DA  - 2026/10/13
JO  - iScience
DO  - 10.1016/j.isci.2026.117864
UR  - https://www.cell.com/iscience/fulltext/S2589-0042(26)03247-5
AB  - A considerable residual cardiovascular risk persists despite contemporary therapies, highlighting the urgent need to identify potential targets for atherosclerotic cardiovascular disease (ASCVD) onset and progression. Accumulating evidence suggests that platelet-derived growth factor D (PDGFD) may be involved in the development of ASCVD. Herein, we leveraged 20-year longitudinal data from the Chinese Multi-provincial Cohort Study-Proteomics Project, with up to four repeated PDGFD measurements per participant, to estimate the serum PDGFD-ASCVD association. We then emulated the effectiveness of hypothetical reductions in PDGFD serum levels on ASCVD prevention. Our findings suggest that elevated circulating PDGFD levels are associated with higher ASCVD risk and that hypothetical PDGFD-lowering strategies may be associated with reduced long-term ASCVD risk, with an estimated absolute risk reduction of up to approximately 9% under the most intensive intervention scenario. We anticipate that these findings may motivate further investigation of PDGFD-lowering strategies as a potential approach for ASCVD risk reduction.
SN  - 2589-0042
ER  -

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