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Peer-reviewedCC BY-NC-NDBMC plant biology

Development and validation of a KASP marker for a domestication-associated stem diameter allele in sorghum.

  • Aimin Ma1
  • Yingyi Shi1
  • Wenxiu Xu1
  • Xiaoyuan Wu1
  • Guoqi Duan1,2
  • Ruizhen Liu3
  • Huili Yan1,4
  • Yunzhuan Zhou1
  • Jing Li1
  • Zhenfeng Li1
  • Yutao Li1
  • Wei Xuan1,4
2 more authors
  • Haichun Jing1,4
  • Zhenyan He5,6
6 affiliations
  1. 1Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
  2. 2University of Chinese Academy of Sciences, Beijing, 100049, China.
  3. 3College of Agriculture, Shanxi Agricultural University, Taigu, 030801, China.
  4. 4State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
  5. 5Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China. [email protected].
  6. 6State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China. [email protected].
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Abstract

Stem diameter is a key agronomic trait in sorghum (Sorghum bicolor L.), influencing biomass accumulation and stalk strength. It also affects practical outcomes such as mechanical harvesting efficiency and end-use quality. Despite its importance, the genetic basis of this trait remains unclear. To address this, we performed a genome-wide association study (GWAS) on a diverse panel, which identified a candidate locus containing Sobic.010G085400 (SbMADS52), a gene encoding a MADS-box transcription factor. Within this gene, we identified a putative functional G185S substitution associated with both stem thickness and plant height, suggesting a role in stalk architecture. To leverage this variant for breeding, we developed and validated a putative functional KASP marker. Population genetic analyses further revealed that the favorable allele has been under selection since domestication but is less frequent in modern breeding, highlighting an underused genetic resource. Collectively, our study characterizes a candidate regulator of stem morphology and provides a practical marker that may be used for sorghum breeding.

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Cite

BibTeXRIS
BibTeX
@article{ma2026development,
  title = {{Development and validation of a KASP marker for a domestication-associated stem diameter allele in sorghum.}},
  author = {Aimin Ma and Yingyi Shi and Wenxiu Xu and Xiaoyuan Wu and Guoqi Duan and Ruizhen Liu and Huili Yan and Yunzhuan Zhou and Jing Li and Zhenfeng Li and Yutao Li and Wei Xuan and Haichun Jing and Zhenyan He},
  journal = {BMC plant biology},
  year = {2026},
  month = aug,
  doi = {10.1186/s12870-026-09674-5},
  url = {https://europepmc.org/article/MED/42958042},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Development and validation of a KASP marker for a domestication-associated stem diameter allele in sorghum.
AU  - Aimin Ma
AU  - Yingyi Shi
AU  - Wenxiu Xu
AU  - Xiaoyuan Wu
AU  - Guoqi Duan
AU  - Ruizhen Liu
AU  - Huili Yan
AU  - Yunzhuan Zhou
AU  - Jing Li
AU  - Zhenfeng Li
AU  - Yutao Li
AU  - Wei Xuan
AU  - Haichun Jing
AU  - Zhenyan He
PY  - 2026
DA  - 2026/08/01
JO  - BMC plant biology
DO  - 10.1186/s12870-026-09674-5
UR  - https://europepmc.org/article/MED/42958042
AB  - Stem diameter is a key agronomic trait in sorghum (Sorghum bicolor L.), influencing biomass accumulation and stalk strength. It also affects practical outcomes such as mechanical harvesting efficiency and end-use quality. Despite its importance, the genetic basis of this trait remains unclear. To address this, we performed a genome-wide association study (GWAS) on a diverse panel, which identified a candidate locus containing Sobic.010G085400 (SbMADS52), a gene encoding a MADS-box transcription factor. Within this gene, we identified a putative functional G185S substitution associated with both stem thickness and plant height, suggesting a role in stalk architecture. To leverage this variant for breeding, we developed and validated a putative functional KASP marker. Population genetic analyses further revealed that the favorable allele has been under selection since domestication but is less frequent in modern breeding, highlighting an underused genetic resource. Collectively, our study characterizes a candidate regulator of stem morphology and provides a practical marker that may be used for sorghum breeding.
SN  - 1471-2229
ER  -