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Peer-reviewedCC BYAdvanced Agrochem

Advancing herbicide safeners: Integrating structure-guided design, pathway mechanism elucidation, and smart delivery

  • Xile Deng1
  • Yudan Wu1
  • Lianyang Bai1
  1. 1Key Laboratory of Pesticide Assessment, Ministry of Agriculture and Rural Affairs, Yuelu Mountain Laboratory, Hunan Academy of Agricultal Sciences, Changsha 410125, P. R. China
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Abstract

Weeds threaten crop production, and while essential for control, they commonly cause crop damage. Herbicide safeners safeguard crops by selectively enhancing their detoxification pathways, without affecting herbicide efficacy. However, the rational design of safeners still remains a significant challenge. This review focuses on three core strategies for developing novel safeners: (i) structure-guided design, including the structural optimization of commercial and natural safeners; (ii) mechanism-driven design through integrated multi-omics and detoxification pathway analysis; (iii) enabling efficient delivery via advanced smart delivery systems. By integrating recent progress, this review proposes a strategic framework for developing effective, environmentally friendly safeners for current and future herbicides.

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Cite

BibTeXRIS
BibTeX
@article{deng2026advancing,
  title = {{Advancing herbicide safeners: Integrating structure-guided design, pathway mechanism elucidation, and smart delivery}},
  author = {Xile Deng and Yudan Wu and Lianyang Bai},
  journal = {Advanced Agrochem},
  year = {2026},
  month = may,
  doi = {10.1016/j.aac.2026.05.001},
  url = {https://doi.org/10.1016/j.aac.2026.05.001},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Advancing herbicide safeners: Integrating structure-guided design, pathway mechanism elucidation, and smart delivery
AU  - Xile Deng
AU  - Yudan Wu
AU  - Lianyang Bai
PY  - 2026
DA  - 2026/05/20
JO  - Advanced Agrochem
DO  - 10.1016/j.aac.2026.05.001
UR  - https://doi.org/10.1016/j.aac.2026.05.001
AB  - Weeds threaten crop production, and while essential for control, they commonly cause crop damage. Herbicide safeners safeguard crops by selectively enhancing their detoxification pathways, without affecting herbicide efficacy. However, the rational design of safeners still remains a significant challenge. This review focuses on three core strategies for developing novel safeners: (i) structure-guided design, including the structural optimization of commercial and natural safeners; (ii) mechanism-driven design through integrated multi-omics and detoxification pathway analysis; (iii) enabling efficient delivery via advanced smart delivery systems. By integrating recent progress, this review proposes a strategic framework for developing effective, environmentally friendly safeners for current and future herbicides.
SN  - 2773-2371
ER  -