Cochlear histological changes after noise exposure: effects of melatonin and resveratrol in an experimental model.
- 1Faculdade de Medicina da Universidade de Brasília, Laboratory of Otorhinolaryngology Teaching and Research (LEO), Campus Darcy Ribeiro, Asa Norte, Brasília, DF, Brazil.
- 2Faculdade de Medicina da Universidade de Brasília, Research Center for Applied Morphology and Immunology (NuPMIA), Campus Darcy Ribeiro, Asa Norte, Brasília, DF, Brazil.
- 3Faculdade de Medicina da Universidade de Brasília, Laboratory of Otorhinolaryngology Teaching and Research (LEO), Campus Darcy Ribeiro, Asa Norte, Brasília, DF, Brazil. Electronic address: [email protected].
Abstract
Objective
To assess cochlear histological changes and the otoprotective effects of melatonin and resveratrol in Wistar rats exposed to high sound pressure levels.Methods
This was a prospective, longitudinal, in vivo experimental study with heterogeneous male Wistar rats. The animals were divided into groups and treated with or without 10 mg/day of melatonin or resveratrol administered intraperitoneally for 14 days. They were then exposed to or not exposed to white noise (4 kHz; 100 ± 3 dB) for 8 h daily for 10-days. Histological analyses were performed on the spiral ganglion, spiral limbus, spiral ligament, and stria vascularis on days 15 (D15) and 30 (D30), after euthanasia. The data were analyzed by ANOVA.Results
The animals in the control group had a higher number of cells in the analyzed cochlear structures than the noise-exposed group. Treatment with melatonin or resveratrol prevented the noise-induced reduction in the number of neurons in the spiral ganglion, maintaining cell counts similar to those in the control group. Resveratrol was also effective in preserving the spiral ligament.Conclusion
The findings suggest that the preventive administration of antioxidants may be an effective strategy in mitigating noise-induced hearing loss, reinforcing the therapeutic potential of these compounds in preventing hearing impairment.Level of evidence
V.
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BibTeX
@article{novanta2026cochlear,
title = {{Cochlear histological changes after noise exposure: effects of melatonin and resveratrol in an experimental model.}},
author = {Gabriela Guenther Ribeiro Novanta and Ana Carolina Odorizzi Zica and Maria Luiza Queiroz Sampaio and Andressa Alves Caram and Selma Aparecida Souza Kückelhaus and Lucieny Silva Martins Serra and Andre Luiz Lopes Sampaio},
journal = {Brazilian journal of otorhinolaryngology},
year = {2026},
month = oct,
doi = {10.1016/j.bjorl.2026.101930},
url = {https://europepmc.org/article/MED/42874301},
note = {CC BY},
}
RIS
TY - JOUR
TI - Cochlear histological changes after noise exposure: effects of melatonin and resveratrol in an experimental model.
AU - Gabriela Guenther Ribeiro Novanta
AU - Ana Carolina Odorizzi Zica
AU - Maria Luiza Queiroz Sampaio
AU - Andressa Alves Caram
AU - Selma Aparecida Souza Kückelhaus
AU - Lucieny Silva Martins Serra
AU - Andre Luiz Lopes Sampaio
PY - 2026
DA - 2026/10/14
JO - Brazilian journal of otorhinolaryngology
DO - 10.1016/j.bjorl.2026.101930
UR - https://europepmc.org/article/MED/42874301
AB - Objective To assess cochlear histological changes and the otoprotective effects of melatonin and resveratrol in Wistar rats exposed to high sound pressure levels.Methods This was a prospective, longitudinal, in vivo experimental study with heterogeneous male Wistar rats. The animals were divided into groups and treated with or without 10 mg/day of melatonin or resveratrol administered intraperitoneally for 14 days. They were then exposed to or not exposed to white noise (4 kHz; 100 ± 3 dB) for 8 h daily for 10-days. Histological analyses were performed on the spiral ganglion, spiral limbus, spiral ligament, and stria vascularis on days 15 (D15) and 30 (D30), after euthanasia. The data were analyzed by ANOVA.Results The animals in the control group had a higher number of cells in the analyzed cochlear structures than the noise-exposed group. Treatment with melatonin or resveratrol prevented the noise-induced reduction in the number of neurons in the spiral ganglion, maintaining cell counts similar to those in the control group. Resveratrol was also effective in preserving the spiral ligament.Conclusion The findings suggest that the preventive administration of antioxidants may be an effective strategy in mitigating noise-induced hearing loss, reinforcing the therapeutic potential of these compounds in preventing hearing impairment.Level of evidence V.
SN - 1808-8694
SN - 1808-8686
ER -