Deciphering the Association of Fasting Blood Glucose With Gamma-Glutamyl Transferase and Uric Acid: A cross-sectional study in a tertiary care hospital in South India
- 1Department of Biochemistry, Government Medical College & Hospital Cuddalore Dt, Chidambaram, India
- 2Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Puducherry, India
- 3MBBS Student, Government Villupuram Medical College, Villupuram, India
Abstract
Objectives: Fasting hyperglycaemia (FHG) in insulin resistance is due to oxidative stress wherein gamma-glutamyl transferase (GGT) and uric acid (UA) are known to impair insulin secretion from pancreatic beta cells due to their pro-oxidant action and their role in metabolism of antioxidant glutathione. This study aims to determine the association of GGT and UA with FHG and its role in predicting the onset of prediabetes. Methods: This cross-sectional study was conducted in Government Villupuram Medical College, Villupuram, India, from July to December 2023. Individuals in the age range of 25–65 years attending the master health check-up clinic were included. The subjects were classified as normoglycaemic (FBG /dL) or hyperglycaemic (FBG ≥ 100 mg/dL). GGT, UA, glucose (Glu):GGT ratio, Glu:UA ratio, lipid profile and GGT: high-density lipoprotein (HDL) were compared between the two groups using Student's t test. The parameters were compared between the quintiles of glucose using ANOVA. Pearson's correlation was used to analyse the correlation between the study parameters. Results: A total of 500 adults were included in this study. Triglyceride (TG), TG:HDL ratio, GGT, UA and Glu:GGT, Glu:UA and GGT:HDL ratios were significantly high in fifth quintile compared to other glucose quintiles. Glu:UA and Glu:GGT ratios showed significant positive correlation with glucose levels. Receiver operating characteristic analysis showed that Glu:UA ratio was a good predictor of FHG (AUC = 0.808; P Conclusion: Glu:UA and Glu:GGT ratios are surrogate markers of underlying oxidative stress and insulin resistance and good predictors of fasting hyperglycaemia.
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BibTeX
@article{anithasri2026deciphering,
title = {{Deciphering the Association of Fasting Blood Glucose With Gamma-Glutamyl Transferase and Uric Acid: A cross-sectional study in a tertiary care hospital in South India}},
author = {Anbalagan Anithasri and Rajagambeeram Reeta and Velmurugan Hasini},
journal = {Sultan Qaboos University Medical Journal},
year = {2026},
month = jul,
doi = {10.18295/2075-0528.3000},
url = {https://doi.org/10.18295/2075-0528.3000},
note = {CC BY},
}
RIS
TY - JOUR
TI - Deciphering the Association of Fasting Blood Glucose With Gamma-Glutamyl Transferase and Uric Acid: A cross-sectional study in a tertiary care hospital in South India
AU - Anbalagan Anithasri
AU - Rajagambeeram Reeta
AU - Velmurugan Hasini
PY - 2026
DA - 2026/07/01
JO - Sultan Qaboos University Medical Journal
DO - 10.18295/2075-0528.3000
UR - https://doi.org/10.18295/2075-0528.3000
AB - Objectives: Fasting hyperglycaemia (FHG) in insulin resistance is due to oxidative stress wherein gamma-glutamyl transferase (GGT) and uric acid (UA) are known to impair insulin secretion from pancreatic beta cells due to their pro-oxidant action and their role in metabolism of antioxidant glutathione. This study aims to determine the association of GGT and UA with FHG and its role in predicting the onset of prediabetes. Methods: This cross-sectional study was conducted in Government Villupuram Medical College, Villupuram, India, from July to December 2023. Individuals in the age range of 25–65 years attending the master health check-up clinic were included. The subjects were classified as normoglycaemic (FBG /dL) or hyperglycaemic (FBG ≥ 100 mg/dL). GGT, UA, glucose (Glu):GGT ratio, Glu:UA ratio, lipid profile and GGT: high-density lipoprotein (HDL) were compared between the two groups using Student's t test. The parameters were compared between the quintiles of glucose using ANOVA. Pearson's correlation was used to analyse the correlation between the study parameters. Results: A total of 500 adults were included in this study. Triglyceride (TG), TG:HDL ratio, GGT, UA and Glu:GGT, Glu:UA and GGT:HDL ratios were significantly high in fifth quintile compared to other glucose quintiles. Glu:UA and Glu:GGT ratios showed significant positive correlation with glucose levels. Receiver operating characteristic analysis showed that Glu:UA ratio was a good predictor of FHG (AUC = 0.808; P Conclusion: Glu:UA and Glu:GGT ratios are surrogate markers of underlying oxidative stress and insulin resistance and good predictors of fasting hyperglycaemia.
SN - 2075-0528
SN - 2075-051X
ER -