Low-cost geometry-tunable PDMS intraocular lenses fabricated using LCD 3D-printed molds for canine ophthalmic applications
Abstract
This study demonstrates the feasibility of fabricating geometry-tunable polydimethylsiloxane (PDMS) intraocular lens (IOL) prototypes using consumer-grade liquid crystal display (LCD) 3D-printed molds and PDMS casting. A reusable mold fabrication strategy incorporating a PMMA barrier layer successfully eliminated PDMS curing inhibition while preserving the mold geometry for repeated casting. The fabrication workflow accurately replicated a plate-haptic lens with a 6 mm optic and dimensional deviation below 1.5%, while enabling optical power to be tuned from 18 to 42 D by varying mold curvature alone. The fabricated PDMS IOLs exhibited high visible-light transparency (>95%), preliminary focusing ability, resolving power and image contrast comparable to a commercial IOL, acceptable post-treatment cytocompatibility, successful injector-assisted delivery with recovery of the original geometry, and preliminary hydrolytic stability and leachability performance. These results establish a reproducible, low-cost, and customizable fabrication platform for PDMS intraocular lenses and provide a foundation for future optimization toward customizable veterinary ophthalmic applications.
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BibTeX
@article{romphosri2026lowcost,
title = {{Low-cost geometry-tunable PDMS intraocular lenses fabricated using LCD 3D-printed molds for canine ophthalmic applications}},
author = {Suwat Romphosri and Anya Chiradejnant and Titima Lertsrisatit and Orapun Jaturakan and Nalinee Tuntivanich and Sushanta K. Mitra and Charusluk Viphavakit},
journal = {iScience},
year = {2026},
month = oct,
doi = {10.1016/j.isci.2026.117890},
url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03273-6},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Low-cost geometry-tunable PDMS intraocular lenses fabricated using LCD 3D-printed molds for canine ophthalmic applications
AU - Suwat Romphosri
AU - Anya Chiradejnant
AU - Titima Lertsrisatit
AU - Orapun Jaturakan
AU - Nalinee Tuntivanich
AU - Sushanta K. Mitra
AU - Charusluk Viphavakit
PY - 2026
DA - 2026/10/14
JO - iScience
DO - 10.1016/j.isci.2026.117890
UR - https://www.cell.com/iscience/fulltext/S2589-0042(26)03273-6
AB - This study demonstrates the feasibility of fabricating geometry-tunable polydimethylsiloxane (PDMS) intraocular lens (IOL) prototypes using consumer-grade liquid crystal display (LCD) 3D-printed molds and PDMS casting. A reusable mold fabrication strategy incorporating a PMMA barrier layer successfully eliminated PDMS curing inhibition while preserving the mold geometry for repeated casting. The fabrication workflow accurately replicated a plate-haptic lens with a 6 mm optic and dimensional deviation below 1.5%, while enabling optical power to be tuned from 18 to 42 D by varying mold curvature alone. The fabricated PDMS IOLs exhibited high visible-light transparency (>95%), preliminary focusing ability, resolving power and image contrast comparable to a commercial IOL, acceptable post-treatment cytocompatibility, successful injector-assisted delivery with recovery of the original geometry, and preliminary hydrolytic stability and leachability performance. These results establish a reproducible, low-cost, and customizable fabrication platform for PDMS intraocular lenses and provide a foundation for future optimization toward customizable veterinary ophthalmic applications.
SN - 2589-0042
ER -