Mental Health Comorbidity and Health-Related Quality of Life Among U.S. Adults with Asthma: A Population-Based Cross-Sectional Study
- 1Department of Clinical Pharmacy
Abstract
Monira Alwhaibi Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Monira Alwhaibi, Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11149, Saudi Arabia, Email [email protected]: Depression and anxiety commonly coexist with asthma and may be associated with poorer health-related quality of life (HRQoL). This study examined their associations with HRQoL among US adults with asthma using nationally representative Medical Expenditure Panel Survey (MEPS) data.Methods: A cross-sectional study was conducted using 2017– 2022 data from the Medical Expenditure Panel Survey. Adults aged 18 years and older with asthma were categorized into four mutually exclusive groups: asthma only, asthma with depression, asthma with anxiety, and asthma with both depression and anxiety. HRQoL was assessed using the Veterans RAND 12-Item Health Survey (VR-12), which generates Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Multivariable linear regression analyses were performed to examine the associations between asthma groups and HRQoL after adjusting for the confounders while accounting for the complex survey design.Results: The study included 5743 adults with asthma, of whom 68.4% had asthma alone, 10.2% had depression, 11.7% had anxiety, and 9.6% had both depression and anxiety. HRQoL differed significantly across the four groups (both p < 0.0001), with the highest PCS (44.04) and MCS (51.26) scores in the asthma-only group and the lowest scores (37.67 and 37.54, respectively) among those with both depression and anxiety. After adjustment for potential confounders, asthma with anxiety (β = − 6.25, p < 0.001) and asthma with both depression and anxiety (β = − 10.63, p < 0.001) and asthma and depression (β = − 5.344, p < 0.001) were associated with lower MCS scores compared with asthma alone. Participants with both depression and anxiety also had significantly lower PCS scores (β = − 0.85, p < 0.001).Conclusions: Depression and anxiety were associated with poorer HRQoL among US adults with asthma, particularly mental HRQoL. Individuals with both conditions had the greatest impairment, highlighting the potential importance of incorporating mental health assessment into asthma care.Keywords: asthma, depression, anxiety, health-related quality of life, HRQoL, veterans RAND 12-item health survey, mental health
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BibTeX
@article{alwhaibi2026mental,
title = {{Mental Health Comorbidity and Health-Related Quality of Life Among U.S. Adults with Asthma: A Population-Based Cross-Sectional Study}},
author = {Alwhaibi M},
journal = {Patient Preference and Adherence},
year = {2026},
month = nov,
url = {https://www.dovepress.com/mental-health-comorbidity-and-health-related-quality-of-life-among-us--peer-reviewed-fulltext-article-PPA},
note = {CC BY},
}
RIS
TY - JOUR
TI - Mental Health Comorbidity and Health-Related Quality of Life Among U.S. Adults with Asthma: A Population-Based Cross-Sectional Study
AU - Alwhaibi M
PY - 2026
DA - 2026/11/08
JO - Patient Preference and Adherence
UR - https://www.dovepress.com/mental-health-comorbidity-and-health-related-quality-of-life-among-us--peer-reviewed-fulltext-article-PPA
AB - Monira Alwhaibi Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Monira Alwhaibi, Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11149, Saudi Arabia, Email [email protected]: Depression and anxiety commonly coexist with asthma and may be associated with poorer health-related quality of life (HRQoL). This study examined their associations with HRQoL among US adults with asthma using nationally representative Medical Expenditure Panel Survey (MEPS) data.Methods: A cross-sectional study was conducted using 2017– 2022 data from the Medical Expenditure Panel Survey. Adults aged 18 years and older with asthma were categorized into four mutually exclusive groups: asthma only, asthma with depression, asthma with anxiety, and asthma with both depression and anxiety. HRQoL was assessed using the Veterans RAND 12-Item Health Survey (VR-12), which generates Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Multivariable linear regression analyses were performed to examine the associations between asthma groups and HRQoL after adjusting for the confounders while accounting for the complex survey design.Results: The study included 5743 adults with asthma, of whom 68.4% had asthma alone, 10.2% had depression, 11.7% had anxiety, and 9.6% had both depression and anxiety. HRQoL differed significantly across the four groups (both p < 0.0001), with the highest PCS (44.04) and MCS (51.26) scores in the asthma-only group and the lowest scores (37.67 and 37.54, respectively) among those with both depression and anxiety. After adjustment for potential confounders, asthma with anxiety (β = − 6.25, p < 0.001) and asthma with both depression and anxiety (β = − 10.63, p < 0.001) and asthma and depression (β = − 5.344, p < 0.001) were associated with lower MCS scores compared with asthma alone. Participants with both depression and anxiety also had significantly lower PCS scores (β = − 0.85, p < 0.001).Conclusions: Depression and anxiety were associated with poorer HRQoL among US adults with asthma, particularly mental HRQoL. Individuals with both conditions had the greatest impairment, highlighting the potential importance of incorporating mental health assessment into asthma care.Keywords: asthma, depression, anxiety, health-related quality of life, HRQoL, veterans RAND 12-item health survey, mental health
SN - 1177-889X
ER -