Periodontal Disease and Heart Failure: Current Evidence and Perspectives.
- 1Universidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil. [email protected].
- 2Universidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil.
- 3Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Abstract
Purpose of review
Periodontal disease has been increasingly recognized as a chronic inflammatory condition with potential systemic implications, particularly in the cardiovascular system. Heart failure (HF), a pro-inflammatory syndrome with multisystem involvement, remains a major public health burden. This state-of-the-art narrative review aims to analyze the current scientific evidence on the association between periodontal disease and heart failure, emphasizing epidemiological data, cardiac biomarkers, inflammatory mediators, and future perspectives.Recent findings
Current evidence indicates a high prevalence of periodontal disease among patients with HF and suggests associations between periodontal disease and elevated cardiac biomarkers, including NT-proBNP and troponin T, as well as systemic inflammatory mediators such as C-reactive protein, IL-6, and TNF-α. Interventional studies have reported reductions in some of these biomarkers following periodontal treatment, suggesting a potential biological link between periodontal inflammation and HF. However, findings remain heterogeneous, and some studies have failed to demonstrate significant associations. Current evidence supports an association between periodontal disease and heart failure, with systemic inflammation representing a potential biological link. Nevertheless, the heterogeneity of study designs, small sample sizes, and predominance of observational and cross-sectional evidence limit causal inference. Longitudinal studies and randomized clinical trials are needed to clarify causal mechanisms and determine whether periodontal prevention and treatment can contribute to integrated strategies for patients with HF.
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BibTeX
@article{silva2026periodontal,
title = {{Periodontal Disease and Heart Failure: Current Evidence and Perspectives.}},
author = {Alícia Eliege da Silva and Valéria Duarte de Almeida and Gilson Aquino Cavalcante and Roque Ribeiro da Silva Júnior and Daria Raquel Queiroz de Almeida and José Veríssimo Fernandes and Ellany Gurgel Cosme do Nascimento and Cléber de Mesquita Andrade and Thales Allyrio Araújo de Medeiros Fernandes},
journal = {Current cardiology reports},
year = {2026},
month = oct,
doi = {10.1007/s11886-026-02438-5},
url = {https://europepmc.org/article/MED/42891735},
note = {CC BY},
}
RIS
TY - JOUR
TI - Periodontal Disease and Heart Failure: Current Evidence and Perspectives.
AU - Alícia Eliege da Silva
AU - Valéria Duarte de Almeida
AU - Gilson Aquino Cavalcante
AU - Roque Ribeiro da Silva Júnior
AU - Daria Raquel Queiroz de Almeida
AU - José Veríssimo Fernandes
AU - Ellany Gurgel Cosme do Nascimento
AU - Cléber de Mesquita Andrade
AU - Thales Allyrio Araújo de Medeiros Fernandes
PY - 2026
DA - 2026/10/17
JO - Current cardiology reports
DO - 10.1007/s11886-026-02438-5
UR - https://europepmc.org/article/MED/42891735
AB - Purpose of review Periodontal disease has been increasingly recognized as a chronic inflammatory condition with potential systemic implications, particularly in the cardiovascular system. Heart failure (HF), a pro-inflammatory syndrome with multisystem involvement, remains a major public health burden. This state-of-the-art narrative review aims to analyze the current scientific evidence on the association between periodontal disease and heart failure, emphasizing epidemiological data, cardiac biomarkers, inflammatory mediators, and future perspectives.Recent findings Current evidence indicates a high prevalence of periodontal disease among patients with HF and suggests associations between periodontal disease and elevated cardiac biomarkers, including NT-proBNP and troponin T, as well as systemic inflammatory mediators such as C-reactive protein, IL-6, and TNF-α. Interventional studies have reported reductions in some of these biomarkers following periodontal treatment, suggesting a potential biological link between periodontal inflammation and HF. However, findings remain heterogeneous, and some studies have failed to demonstrate significant associations. Current evidence supports an association between periodontal disease and heart failure, with systemic inflammation representing a potential biological link. Nevertheless, the heterogeneity of study designs, small sample sizes, and predominance of observational and cross-sectional evidence limit causal inference. Longitudinal studies and randomized clinical trials are needed to clarify causal mechanisms and determine whether periodontal prevention and treatment can contribute to integrated strategies for patients with HF.
SN - 1523-3782
SN - 1534-3170
ER -