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PreprintCC BY-NCChemRxiv

Rapid, High-Yielding, and Broad-Scope Silicon-Noded Single-Atom Ligation Platform

  • Jie Wang1,2
  • Zhiyou Hu1,2
  • Youliang Wang1,2
  1. 1School of Chemistry, Xi’an Key Laboratory of Sustainable Energy Materials Chemistry
  2. 2Xi’an Jiaotong University (XJTU
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Abstract

The node–module logic underpins DNA, RNA, and metal–organic frameworks. In small-molecule synthesis, SuFEx and PFEx exploit sulfur or phosphorus as single‑atom nodes for 10 modular ligations but are largely confined to amine and phenol modules. Silicon‑based ligation would offer a viable alternative, as both alcohols and phenols can serve as reliable modules, yet it has lacked efficient and controllable platforms. Herein, we report a silicon-noded ligation platform using bis(2,4,6-trimethoxyphenyl)silanes (bis(TMP)silanes) as the ligation hubs, enabling rapid, high-yielding ligation of both alcohol and phenol modules with broad functional-group tolerance.

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Cite

BibTeXRIS
BibTeX
@misc{wang2026rapid,
  title = {{Rapid, High-Yielding, and Broad-Scope Silicon-Noded Single-Atom Ligation Platform}},
  author = {Jie Wang and Zhiyou Hu and Youliang Wang},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009106/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009106/v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - Rapid, High-Yielding, and Broad-Scope Silicon-Noded Single-Atom Ligation Platform
AU  - Jie Wang
AU  - Zhiyou Hu
AU  - Youliang Wang
PY  - 2026
DA  - 2026/09/20
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009106/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009106/v1
AB  - The node–module logic underpins DNA, RNA, and metal–organic frameworks. In small-molecule synthesis, SuFEx and PFEx exploit sulfur or phosphorus as single‑atom nodes for 10 modular ligations but are largely confined to amine and phenol modules. Silicon‑based ligation would offer a viable alternative, as both alcohols and phenols can serve as reliable modules, yet it has lacked efficient and controllable platforms. Herein, we report a silicon-noded ligation platform using bis(2,4,6-trimethoxyphenyl)silanes (bis(TMP)silanes) as the ligation hubs, enabling rapid, high-yielding ligation of both alcohol and phenol modules with broad functional-group tolerance.
ER  -