8th International consensus guidelines for the management of advanced breast cancer (ABC8 guidelines)

@article{cardoso2026international,
  title = {{8th International consensus guidelines for the management of advanced breast cancer (ABC8 guidelines)}},
  author = {Fatima Cardoso and Joana Mourato Ribeiro and Eva Schumacher-Wulf and Sandra M Swain and Shani Paluch-Shimon and Frederique Penault-Llorca and Nancy U Lin and Prudence A Francis and Marion Kuper-Hommel and Anne May and Florentine Hilbers and Angel Guerrero and Matti S Aapro and Rania Azmi and Jyoti Bajpai and Carlos Barrios and Laura Biganzoli and Fran Boyle and Valeria Caceres and Lisa A Carey and Mariana Chavez-MacGregor and Javier Cortés and Rebecca Dent and Amanda Drury and Nagi S El Saghir and Hesham Elghazaly and Alexandru Eniu and Lesley Fallowfield and Sandra Ximena Franco Millan and Karen Gelmon and Jenny Gilchrist and Joseph Gligorov and William J Gradishar and Nadia Harbeck and Xichun Hu and Orit Kaidar-Person and Ranjit Kaur and Belinda Kiely and Sung-Bae Kim and Sarah Kutika Nyagabona and Maryam Lustberg and Volkmar Mueller and Miriam Mutebi and Silvia Neciosup and Shinji Ohno and Barbara Pistilli and Hope S Rugo and Tanja Spanic and Janice Tsang and Peter Vuylsteke and Binghe Xu and Larry Norton and Eric P Winer},
  journal = {The Breast : Official Journal of the European Society of Mastology},
  year = {2026},
  month = sep,
  doi = {10.1016/j.breast.2026.104921},
  url = {https://doi.org/10.1016/j.breast.2026.104921},
  note = {CC BY-NC-ND 4.0},
}

TY  - JOUR
TI  - 8th International consensus guidelines for the management of advanced breast cancer (ABC8 guidelines)
AU  - Fatima Cardoso
AU  - Joana Mourato Ribeiro
AU  - Eva Schumacher-Wulf
AU  - Sandra M Swain
AU  - Shani Paluch-Shimon
AU  - Frederique Penault-Llorca
AU  - Nancy U Lin
AU  - Prudence A Francis
AU  - Marion Kuper-Hommel
AU  - Anne May
AU  - Florentine Hilbers
AU  - Angel Guerrero
AU  - Matti S Aapro
AU  - Rania Azmi
AU  - Jyoti Bajpai
AU  - Carlos Barrios
AU  - Laura Biganzoli
AU  - Fran Boyle
AU  - Valeria Caceres
AU  - Lisa A Carey
AU  - Mariana Chavez-MacGregor
AU  - Javier Cortés
AU  - Rebecca Dent
AU  - Amanda Drury
AU  - Nagi S El Saghir
AU  - Hesham Elghazaly
AU  - Alexandru Eniu
AU  - Lesley Fallowfield
AU  - Sandra Ximena Franco Millan
AU  - Karen Gelmon
AU  - Jenny Gilchrist
AU  - Joseph Gligorov
AU  - William J Gradishar
AU  - Nadia Harbeck
AU  - Xichun Hu
AU  - Orit Kaidar-Person
AU  - Ranjit Kaur
AU  - Belinda Kiely
AU  - Sung-Bae Kim
AU  - Sarah Kutika Nyagabona
AU  - Maryam Lustberg
AU  - Volkmar Mueller
AU  - Miriam Mutebi
AU  - Silvia Neciosup
AU  - Shinji Ohno
AU  - Barbara Pistilli
AU  - Hope S Rugo
AU  - Tanja Spanic
AU  - Janice Tsang
AU  - Peter Vuylsteke
AU  - Binghe Xu
AU  - Larry Norton
AU  - Eric P Winer
PY  - 2026
DA  - 2026/09/17
JO  - The Breast : Official Journal of the European Society of Mastology
DO  - 10.1016/j.breast.2026.104921
UR  - https://doi.org/10.1016/j.breast.2026.104921
AB  - The Advanced Breast Cancer (ABC) 8th international consensus conference took place on 6-8 November 2025, in Lisbon, and updated the previous ABC international consensus guidelines that are described in this manuscript. These guidelines reflect the work of a large and global consensus panel, comprising healthcare professionals and patients, and provide recommendations on how to best manage patients with advanced breast cancer (inoperable locally advanced or metastatic), of all breast cancer subtypes. The guidelines are based on the best available evidence or on expert opinion when a higher level of evidence is lacking and aim to cover the needs of the person living with ABC, including but also beyond the main therapeutic recommendations. Each guideline is accompanied by the level of evidence (LoE), the grade of recommendation (GoR), and the percentage of consensus reached at the consensus session. Updated diagnostic and treatment algorithms are also provided. These guidelines are endorsed by several international oncology organizations (AGO, AORTIC, ECO, EONS, ESO, ESTRO, EUSOMA, GECO Perú, SUMA, MASCC, French Breast Cancer Guidelines and AMAAC) and have official representation from ASCO, NCCN and ABC-NZ.  Inequalities in access to high-quality care have increased in the last decade, both between and within countries, and are a major concern. The ABC guidelines provide guidance on the best available management options for patients living with ABC globally, assuming availability of the recommended therapies. Their adaptation is often needed in resource-constrained settings, and the grading of each recommendation may help in prioritizing access to available options.
SN  - 0960-9776
SN  - 1532-3080
ER  -