Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study

@article{maloberti2026prevalence,
  title = {{Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study}},
  author = {Alessandro Maloberti and Giulia Capitoli and Tommaso Valobra and Paola Rebora and Nicolas Mavreas and Silvia Vergani and Valentina Giani and Chiara Tognola and Nicolò Capsoni and Michele Galasso and Lorenzo De Censi and Cecilia Ferretti and Andrea Sultana and Gabriele Peraro and Martina Morelli and Annalisa Giacalone and Ilaria Garofani and Filippo Galbiati and Michele Bombelli and Cristina Giannattasio},
  journal = {Hypertension Research},
  year = {2026},
  month = sep,
  doi = {10.1038/s41440-026-02788-1},
  url = {https://doi.org/10.1038/s41440-026-02788-1},
  note = {CC BY 4.0},
}

TY  - JOUR
TI  - Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study
AU  - Alessandro Maloberti
AU  - Giulia Capitoli
AU  - Tommaso Valobra
AU  - Paola Rebora
AU  - Nicolas Mavreas
AU  - Silvia Vergani
AU  - Valentina Giani
AU  - Chiara Tognola
AU  - Nicolò Capsoni
AU  - Michele Galasso
AU  - Lorenzo De Censi
AU  - Cecilia Ferretti
AU  - Andrea Sultana
AU  - Gabriele Peraro
AU  - Martina Morelli
AU  - Annalisa Giacalone
AU  - Ilaria Garofani
AU  - Filippo Galbiati
AU  - Michele Bombelli
AU  - Cristina Giannattasio
PY  - 2026
DA  - 2026/09/02
JO  - Hypertension Research
DO  - 10.1038/s41440-026-02788-1
UR  - https://doi.org/10.1038/s41440-026-02788-1
AB  - Very heterogeneous data have been published concerning prevalence and clinical management of Hypertensive Emergencies (HE) and Uncontrolled Hypertension (UH). The aim of our study was to characterize HE and UH patients evaluating: (i) Blood Pressure (BP) management in Emergency Department (ED), the pharmacological treatment and its adherence to guidelines recommendation; (ii) variables associated with the presence of organ damage; and (iii), as an exploratory analysis, the impact of BP on in-hospital mortality. We performed a multicentre (Niguarda Hospital - Milan and Pio XI Hospital – Desio) retrospective study evaluating patients admitted to ED with BP values ≥ 180/120 mmHg during 2017 and 2019. 1838 patients were admitted to the ED with a BP ≥ 180/120 mmHg (0.95% of total admissions) of whom 37.7% were HE and the remaining (62.3%) were UH. The reduction in Systolic and Diastolic BP (SBP/DBP respectively) was similar in HE (40.6/16.9 ± 26.3/17.7 mmHg) and UH (39.3/15.5 ± 22.4/16.0 mmHg). The most used drugs were intravenous furosemide, nitroglycerin, clonidine and labetalol for HE. Age, smoking, heart failure, previous acute coronary syndrome, chronic kidney disease and diabetes mellitus present a positive association HEs while female sex and chronic anti-hypertensive therapies with 2 or more drugs results as protective variables. Finally, regarding the exploratory analysis, BP at ED admission and its management didn’t present significant association with in-hospital mortality. In conclusions, our study demonstrated that adherence to guidelines in the management of HE/UH could be further improved.
SN  - 0916-9636
SN  - 1348-4214
ER  -