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Peer-reviewedCC BY 4.0Genome Biology

Genome-wide scan for transmission ratio distortion in trios from the Norwegian MoBa cohort rules out moderate distortion at common variants

  • Shannon D’Urso
  • Elizabeth C. Corfield
  • Laurie J. Hannigan
  • Ole A. Andreassen
  • Astanand Jugessur
  • Kasper Munch
  • George Davey Smith
  • Gibran Hemani
  • Liang-Dar Hwang
  • Gunn-Helen Moen
  • Alexandra Havdahl
  • David M. Evans
Open at sourceDOICite

Abstract

Transmission ratio distortion has been demonstrated in model organisms but is understudied in humans. We conduct single- and multi-locus transmission disequilibrium tests to detect transmission ratio distortion in up to 43,829 parent–offspring trios from the Norwegian Mother, Father and Child Cohort Study. We find little evidence for moderate to high levels of transmission ratio distortion at common variants. However, our multi-locus analyses implicate genes involved in meiosis, fertility, and prenatal development.

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Cite

BibTeXRIS
BibTeX
@article{durso2026genomewide,
  title = {{Genome-wide scan for transmission ratio distortion in trios from the Norwegian MoBa cohort rules out moderate distortion at common variants}},
  author = {Shannon D’Urso and Elizabeth C. Corfield and Laurie J. Hannigan and Ole A. Andreassen and Astanand Jugessur and Kasper Munch and George Davey Smith and Gibran Hemani and Liang-Dar Hwang and Gunn-Helen Moen and Alexandra Havdahl and David M. Evans},
  journal = {Genome Biology},
  year = {2026},
  month = nov,
  doi = {10.1186/s13059-026-04333-2},
  url = {https://link.springer.com/article/10.1186/s13059-026-04333-2},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Genome-wide scan for transmission ratio distortion in trios from the Norwegian MoBa cohort rules out moderate distortion at common variants
AU  - Shannon D’Urso
AU  - Elizabeth C. Corfield
AU  - Laurie J. Hannigan
AU  - Ole A. Andreassen
AU  - Astanand Jugessur
AU  - Kasper Munch
AU  - George Davey Smith
AU  - Gibran Hemani
AU  - Liang-Dar Hwang
AU  - Gunn-Helen Moen
AU  - Alexandra Havdahl
AU  - David M. Evans
PY  - 2026
DA  - 2026/11/05
JO  - Genome Biology
DO  - 10.1186/s13059-026-04333-2
UR  - https://link.springer.com/article/10.1186/s13059-026-04333-2
AB  - Transmission ratio distortion has been demonstrated in model organisms but is understudied in humans. We conduct single- and multi-locus transmission disequilibrium tests to detect transmission ratio distortion in up to 43,829 parent–offspring trios from the Norwegian Mother, Father and Child Cohort Study. We find little evidence for moderate to high levels of transmission ratio distortion at common variants. However, our multi-locus analyses implicate genes involved in meiosis, fertility, and prenatal development.
SN  - 1474-760X
ER  -