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Peer-reviewedCC BYJournal of Cancer

Impact of FOSL1 polymorphisms and expression on disease progression in oral tongue squamous cell carcinoma.

  • Ping-Ju Chen1,2,3
  • Yi-Tzu Chen4,5,6
  • Chun-Yi Chuang7,8
  • Chun-Wen Su3,9
  • Shun-Fa Yang3,9
  • Ying-Erh Chou7,9
  • Chiao-Wen Lin5,6
9 affiliations
  1. 1Department of Dentistry, Changhua Christian Hospital, Changhua, Taiwan.
  2. 2Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
  3. 3Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  4. 4School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
  5. 5Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
  6. 6Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.
  7. 7School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  8. 8Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan.
  9. 9Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
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Abstract

Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer, with betel quid chewing, tobacco smoking, and alcohol consumption recognized as major risk factors. This study investigated the associations between FOSL1 single-nucleotide polymorphisms (SNPs) and disease susceptibility and clinicopathological characteristics in OTSCC patients. Three FOSL1 SNPs (rs637571, rs653914, and rs10896065) were genotyped in 377 male OTSCC patients and 1,194 controls using real-time polymerase chain reaction. The FOSL1 rs10896065 polymorphic T variant was significantly associated with advanced clinical stage (Stage III-IV; AOR = 1.663, 95% CI = 1.059-2.611, p = 0.027) and larger tumor size (AOR = 1.813, 95% CI = 1.162-2.831, p = 0.009). Among betel quid chewers, carriers of the CT+TT genotype showed significant associations with advanced clinical stage, larger tumor size, and moderate-to-poor tumor differentiation. Similar associations with advanced stage and greater tumor size were observed among smokers carrying the CT+TT genotype. Analysis of The Cancer Genome Atlas dataset further demonstrated that elevated FOSL1 mRNA expression was significantly associated with larger tumor size (T3-T4 vs. T1-T2, p = 0.0216). These findings suggest that the FOSL1 rs10896065 T allele is associated with advanced clinicopathological features in OTSCC patients, particularly among betel-quid chewers and smokers. FOSL1 polymorphisms may have potential as biomarkers associated with clinicopathological characteristics in OTSCC.

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Cite

BibTeXRIS
BibTeX
@article{chen2026impact,
  title = {{Impact of FOSL1 polymorphisms and expression on disease progression in oral tongue squamous cell carcinoma.}},
  author = {Ping-Ju Chen and Yi-Tzu Chen and Chun-Yi Chuang and Chun-Wen Su and Shun-Fa Yang and Ying-Erh Chou and Chiao-Wen Lin},
  journal = {Journal of Cancer},
  year = {2026},
  month = oct,
  doi = {10.7150/jca.142594},
  url = {https://europepmc.org/article/MED/42910380},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Impact of FOSL1 polymorphisms and expression on disease progression in oral tongue squamous cell carcinoma.
AU  - Ping-Ju Chen
AU  - Yi-Tzu Chen
AU  - Chun-Yi Chuang
AU  - Chun-Wen Su
AU  - Shun-Fa Yang
AU  - Ying-Erh Chou
AU  - Chiao-Wen Lin
PY  - 2026
DA  - 2026/10/16
JO  - Journal of Cancer
DO  - 10.7150/jca.142594
UR  - https://europepmc.org/article/MED/42910380
AB  - Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer, with betel quid chewing, tobacco smoking, and alcohol consumption recognized as major risk factors. This study investigated the associations between FOSL1 single-nucleotide polymorphisms (SNPs) and disease susceptibility and clinicopathological characteristics in OTSCC patients. Three FOSL1 SNPs (rs637571, rs653914, and rs10896065) were genotyped in 377 male OTSCC patients and 1,194 controls using real-time polymerase chain reaction. The FOSL1 rs10896065 polymorphic T variant was significantly associated with advanced clinical stage (Stage III-IV; AOR = 1.663, 95% CI = 1.059-2.611, p = 0.027) and larger tumor size (AOR = 1.813, 95% CI = 1.162-2.831, p = 0.009). Among betel quid chewers, carriers of the CT+TT genotype showed significant associations with advanced clinical stage, larger tumor size, and moderate-to-poor tumor differentiation. Similar associations with advanced stage and greater tumor size were observed among smokers carrying the CT+TT genotype. Analysis of The Cancer Genome Atlas dataset further demonstrated that elevated FOSL1 mRNA expression was significantly associated with larger tumor size (T3-T4 vs. T1-T2, p = 0.0216). These findings suggest that the FOSL1 rs10896065 T allele is associated with advanced clinicopathological features in OTSCC patients, particularly among betel-quid chewers and smokers. FOSL1 polymorphisms may have potential as biomarkers associated with clinicopathological characteristics in OTSCC.
SN  - 1837-9664
ER  -