Reduction in Heart Failure Hospitalizations Through Real-World HeartLogicTM Alert Response ― A Multicenter Study in Japan ―
Abstract
BACKGROUND: (HL) is a multiparametric remote monitoring system designed to detect early signs of HF decompensation. Using a multicenter database, this real-world study evaluated whether responses to HL alerts could reduce HF-related hospitalization. METHODS AND RESULTS: We retrospectively analyzed 246 patients implanted with an HL-enabled implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator across 8 Japanese centers. Patients were categorized as alert-responsive (AR; n=167) or non-responsive (NR; n=79). Alert responses included multidisciplinary review and telephone triage to determine the need for clinical visits. HF hospitalization rates during the alert-off (before activation) and the alert-on (after alert activation) periods were compared. During the alert-off period, 50 hospitalizations occurred over 648 person-years (77.1 per 1,000 person-years); during the alert-on, 91 hospitalizations occurred over 498 person-years (182.6 per 1,000 person-years). From the alert-off to the alert-on period, HF hospitalization increased 3.24-fold (95% confidence interval [CI] 1.63-6.41) in the NR group, but only 1.28-fold (95% CI 0.81-2.03) in the AR group. The relative increase in HF hospitalization was significantly attenuated in the AR group (adjusted relative ratio 0.40; 95% CI 0.18-0.89; P=0.025). CONCLUSIONS: Although HF-related hospitalizations progressively increase as the disease advances, real-world alert responses may reduce hospitalizations and healthcare costs in clinical practice.
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BibTeX
@article{oka2026reduction,
title = {{Reduction in Heart Failure Hospitalizations Through Real-World HeartLogicTM Alert Response ― A Multicenter Study in Japan ―}},
author = {Takafumi Oka and Mitsuyoshi Takahara and Shohei Kataoka and Michio Nagashima and Koumei Onuki and Daigo Yagishita and Yoshifumi Ikeda and Risa Kanai and Yoshitaka Terazaki and Yasuhiro Yoshiga and Masakazu Fukuda and Takuo Tsurugi and Katsuhito Fujiu and Eriko Hasumi and Nobuhiro Nishii and Hiroki Iguchi and Yasushi Sakata},
journal = {Circulation Journal},
year = {2026},
month = oct,
doi = {10.1253/circj.cj-26-0182},
url = {https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0182/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Reduction in Heart Failure Hospitalizations Through Real-World HeartLogicTM Alert Response ― A Multicenter Study in Japan ―
AU - Takafumi Oka
AU - Mitsuyoshi Takahara
AU - Shohei Kataoka
AU - Michio Nagashima
AU - Koumei Onuki
AU - Daigo Yagishita
AU - Yoshifumi Ikeda
AU - Risa Kanai
AU - Yoshitaka Terazaki
AU - Yasuhiro Yoshiga
AU - Masakazu Fukuda
AU - Takuo Tsurugi
AU - Katsuhito Fujiu
AU - Eriko Hasumi
AU - Nobuhiro Nishii
AU - Hiroki Iguchi
AU - Yasushi Sakata
PY - 2026
DA - 2026/10/23
JO - Circulation Journal
DO - 10.1253/circj.cj-26-0182
UR - https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0182/_article
AB - BACKGROUND: (HL) is a multiparametric remote monitoring system designed to detect early signs of HF decompensation. Using a multicenter database, this real-world study evaluated whether responses to HL alerts could reduce HF-related hospitalization. METHODS AND RESULTS: We retrospectively analyzed 246 patients implanted with an HL-enabled implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator across 8 Japanese centers. Patients were categorized as alert-responsive (AR; n=167) or non-responsive (NR; n=79). Alert responses included multidisciplinary review and telephone triage to determine the need for clinical visits. HF hospitalization rates during the alert-off (before activation) and the alert-on (after alert activation) periods were compared. During the alert-off period, 50 hospitalizations occurred over 648 person-years (77.1 per 1,000 person-years); during the alert-on, 91 hospitalizations occurred over 498 person-years (182.6 per 1,000 person-years). From the alert-off to the alert-on period, HF hospitalization increased 3.24-fold (95% confidence interval [CI] 1.63-6.41) in the NR group, but only 1.28-fold (95% CI 0.81-2.03) in the AR group. The relative increase in HF hospitalization was significantly attenuated in the AR group (adjusted relative ratio 0.40; 95% CI 0.18-0.89; P=0.025). CONCLUSIONS: Although HF-related hospitalizations progressively increase as the disease advances, real-world alert responses may reduce hospitalizations and healthcare costs in clinical practice.
SN - 1347-4820
SN - 1346-9843
ER -