An altered B cell compartment distinguishes low antibody responders among people with HIV
- 1Department of Molecular M
Abstract
Chronic HIV infection can leave persistent immune dysregulation despite effective antiretroviral therapy (ART), but how this altered immune landscape affects antibody induction and durability after antigen exposure remains unclear. We used SARS-CoV-2 infection and vaccination as a model of humoral immunity to a novel antigen, evaluating anti-RBD IgG titers and immune cell phenotypes in people with HIV (PWH) and without HIV (PWoH) with hybrid immunity, stratified by early (<90 days) or late ([≥]90 days) post-exposure time points. PWH who failed to mount protective anti-RBD IgG titers early had a B cell compartment that was distinct from PWoH and high-titer PWH. Specifically, low-titer PWH had the highest expansion of activated naive, CD11c age-associated, and IgM-skewed B cells with reduced regulatory marker expression, even after controlling for age, sex, BMI and days since infection. PWH who had low-titer responses during the late phase of the response had persistent CD11c-associated features with expansion of double-negative and altered class-switched memory B cell compartments. These B cell features correlated with CD4 and CD8 T cell activation and senescence-associated phenotypes, suggesting that failure to mount high titer antibody response and maintenance in a subset of PWH is shaped by coordinated immune dysregulation.
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BibTeX
@misc{redinger2026altered,
title = {{An altered B cell compartment distinguishes low antibody responders among people with HIV}},
author = {K. Redinger and S. B. Warner and A. Jamal and N. Gallego Marquez and M. Mendoza and D. Sanin and M. J. Peluso and A. L. Landay and A. L. Cox and A. A. R. Antar and E. A. Thompson},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.18.26363407},
url = {https://www.medrxiv.org/content/10.64898/2026.09.18.26363407v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - An altered B cell compartment distinguishes low antibody responders among people with HIV
AU - K. Redinger
AU - S. B. Warner
AU - A. Jamal
AU - N. Gallego Marquez
AU - M. Mendoza
AU - D. Sanin
AU - M. J. Peluso
AU - A. L. Landay
AU - A. L. Cox
AU - A. A. R. Antar
AU - E. A. Thompson
PY - 2026
DA - 2026/09/18
PB - medRxiv
DO - 10.64898/2026.09.18.26363407
UR - https://www.medrxiv.org/content/10.64898/2026.09.18.26363407v1
AB - Chronic HIV infection can leave persistent immune dysregulation despite effective antiretroviral therapy (ART), but how this altered immune landscape affects antibody induction and durability after antigen exposure remains unclear. We used SARS-CoV-2 infection and vaccination as a model of humoral immunity to a novel antigen, evaluating anti-RBD IgG titers and immune cell phenotypes in people with HIV (PWH) and without HIV (PWoH) with hybrid immunity, stratified by early (<90 days) or late ([≥]90 days) post-exposure time points. PWH who failed to mount protective anti-RBD IgG titers early had a B cell compartment that was distinct from PWoH and high-titer PWH. Specifically, low-titer PWH had the highest expansion of activated naive, CD11c age-associated, and IgM-skewed B cells with reduced regulatory marker expression, even after controlling for age, sex, BMI and days since infection. PWH who had low-titer responses during the late phase of the response had persistent CD11c-associated features with expansion of double-negative and altered class-switched memory B cell compartments. These B cell features correlated with CD4 and CD8 T cell activation and senescence-associated phenotypes, suggesting that failure to mount high titer antibody response and maintenance in a subset of PWH is shaped by coordinated immune dysregulation.
ER -