Skip to content
DraconiticResearch
Search Sources API
194,230 studies31 sourcesUpdated 25 min ago
Peer-reviewedCC BY 4.0Frontiers in Immunology

Case Report: A rare case of biopsy-proven lupus nephritis complicated by Graves’ disease in a 39-year-old man

  • Xichang Wang1
  • Xiaoguang Shi1
  • Beiru Zhang2
  • Mi Tian2
  1. 1Department of Endocrinology, Shengjing Hospital of China Medical University
  2. 2Department of Nephrology, Shengjing Hospital of China Medical University
Open at sourcePDFDOICite

Abstract

Hyperthyroidism and systemic lupus erythematosus (SLE) are both common diseases in internal medicine. Among them, Graves’ disease (GD) is the most frequent cause of hyperthyroidism, while lupus nephritis (LN) represents one of the most severe organ manifestations of SLE. Basic research suggests that GD and SLE may share overlapping genetic and immunological pathways; however, whether these shared mechanisms contribute to their clinical coexistence remains uncertain. Clinical studies or case reports on their coexistence are currently limited, and we cannot effectively manage cases of co-occurrence based on authoritative guidelines or expert consensus. In this study, we report a 39-year-old male patient with biopsy-proven ISN/RPS Class IV + V LN concomitant with GD. The patient was treated with a combination of glucocorticoids, mycophenolate mofetil, and hydroxychloroquine for LN, along with methimazole for GD, supplemented by symptomatic therapy including antihypertensive and heart rate controlling agents, etc. The patient demonstrated early clinical and laboratory improvement during follow-up, although the limited follow-up precluded assessment of an established renal response.

Related

  1. Phenotypic shift from active class IV lupus nephritis to lupus podocytopathy: a case report highlighting the treatment-altering role of repeat kidney biopsy
    Zhifa Wang, Jinxiu Deng, Jinfeng Shen +2
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0Full textImmunologyCrossrefEurope PMC
  2. Assessment of biopsy‐proven liver fibrosis by two‐dimensional shear wave elastography: An individual patient data‐based meta‐analysis
    Eva Herrmann, Victor de Lédinghen, Christophe Cassinotto +28
    HepatologyPeer-reviewedHAL deposit licenceFull text466 citedSystems & synthetic biologyMedical imaging & radiologyHAL
  3. Anti-Glomerular Basement Membrane Antibody Disease Complicated by Complement-Mediated Thrombotic Microangiopathy: A Case Report
    Ryo Okino, Yoshitada Toyota, Takaaki Kaji +4
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textImmunologyJ-STAGE
  4. Urinary CXCL9 and CXCL10, Interstitial Inflammation, and Disease Activity Over Time in Acute Interstitial Nephritis
    François Husser, Olivier Aubert, Stéphanie Chhun +12
    American Journal of Kidney DiseasesPeer-reviewedCC BY 4.0Full textGeneral biologyGeneral medicineHAL
  5. Domestically Acquired Leptospirosis Complicated by Myocardial Involvement: A Case Report from Japan
    Hiroaki Matsuda, Takahiro Sakamoto, Yuki Yoshioka +5
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textMicrobiologyJ-STAGE

Cite

BibTeXRIS
BibTeX
@article{wang2026case,
  title = {{Case Report: A rare case of biopsy-proven lupus nephritis complicated by Graves’ disease in a 39-year-old man}},
  author = {Xichang Wang and Xiaoguang Shi and Beiru Zhang and Mi Tian},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1908289},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1908289/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Case Report: A rare case of biopsy-proven lupus nephritis complicated by Graves’ disease in a 39-year-old man
AU  - Xichang Wang
AU  - Xiaoguang Shi
AU  - Beiru Zhang
AU  - Mi Tian
PY  - 2026
DA  - 2026/10/28
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1908289
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1908289/full
AB  - Hyperthyroidism and systemic lupus erythematosus (SLE) are both common diseases in internal medicine. Among them, Graves’ disease (GD) is the most frequent cause of hyperthyroidism, while lupus nephritis (LN) represents one of the most severe organ manifestations of SLE. Basic research suggests that GD and SLE may share overlapping genetic and immunological pathways; however, whether these shared mechanisms contribute to their clinical coexistence remains uncertain. Clinical studies or case reports on their coexistence are currently limited, and we cannot effectively manage cases of co-occurrence based on authoritative guidelines or expert consensus. In this study, we report a 39-year-old male patient with biopsy-proven ISN/RPS Class IV + V LN concomitant with GD. The patient was treated with a combination of glucocorticoids, mycophenolate mofetil, and hydroxychloroquine for LN, along with methimazole for GD, supplemented by symptomatic therapy including antihypertensive and heart rate controlling agents, etc. The patient demonstrated early clinical and laboratory improvement during follow-up, although the limited follow-up precluded assessment of an established renal response.
SN  - 1664-3224
ER  -