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Peer-reviewedCC BY 4.0Frontiers in Oncology

Multidisciplinary approach with stereotactic reirradiation to oligoprogressive spinal metastases from dedifferentiated osteosarcoma: a case report

  • Arkadiusz Moskwa1
  • Paulina Chmiel1
  • Katarzyna Kozak1
  • Michał Wągrodzki2
  • Piotr Rutkowski1
  • Mateusz Spałek1,3
  1. 1Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology
  2. 2Department of Pathology, Maria Sklodowska-Curie National Research Institute of Oncology
  3. 3Department of Radiotherapy I, Maria Sklodowska-Curie National Research Institute of Oncology
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Abstract

Background: Stereotactic body radiotherapy (SBRT) has emerged as a promising therapeutic approach for vertebral metastases, achieving high local control and safety. However, evidence on spinal reirradiation with SBRT is limited, and data are especially scarce for radioresistant histologies such as osteosarcoma.

Case report: We present the first case of a second reirradiation in radioresistant metastatic osteosarcoma, with each consecutive course of radiotherapy administered at an interval of at least 6 months. After multiple surgical interventions in the cervical and thoracic spine and three lines of chemotherapy, the patient demonstrated local progression in the C-Th region of the spine, which was successfully treated with a third SBRT, achieving a partial response without any acute adverse events.

Conclusions: SBRT for spinal metastases reirradiation has seen a growing trend in recent years. Preliminary studies, as well as the following case report, demonstrate its usefulness, effectiveness, and safety in a carefully selected group of patients. In this particular instance, even a third SBRT course has been demonstrated to yield clinical benefits and can be executed safely, provided that it is administered in accordance with proper technical regimens and critical organ sparing strategies.

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Cite

BibTeXRIS
BibTeX
@article{moskwa2026multidisciplinary,
  title = {{Multidisciplinary approach with stereotactic reirradiation to oligoprogressive spinal metastases from dedifferentiated osteosarcoma: a case report}},
  author = {Arkadiusz Moskwa and Paulina Chmiel and Katarzyna Kozak and Michał Wągrodzki and Piotr Rutkowski and Mateusz Spałek},
  journal = {Frontiers in Oncology},
  year = {2026},
  month = oct,
  doi = {10.3389/fonc.2026.1929146},
  url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1929146/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Multidisciplinary approach with stereotactic reirradiation to oligoprogressive spinal metastases from dedifferentiated osteosarcoma: a case report
AU  - Arkadiusz Moskwa
AU  - Paulina Chmiel
AU  - Katarzyna Kozak
AU  - Michał Wągrodzki
AU  - Piotr Rutkowski
AU  - Mateusz Spałek
PY  - 2026
DA  - 2026/10/26
JO  - Frontiers in Oncology
DO  - 10.3389/fonc.2026.1929146
UR  - https://www.frontiersin.org/articles/10.3389/fonc.2026.1929146/full
AB  - Background: Stereotactic body radiotherapy (SBRT) has emerged as a promising therapeutic approach for vertebral metastases, achieving high local control and safety. However, evidence on spinal reirradiation with SBRT is limited, and data are especially scarce for radioresistant histologies such as osteosarcoma.  Case report: We present the first case of a second reirradiation in radioresistant metastatic osteosarcoma, with each consecutive course of radiotherapy administered at an interval of at least 6 months. After multiple surgical interventions in the cervical and thoracic spine and three lines of chemotherapy, the patient demonstrated local progression in the C-Th region of the spine, which was successfully treated with a third SBRT, achieving a partial response without any acute adverse events.  Conclusions: SBRT for spinal metastases reirradiation has seen a growing trend in recent years. Preliminary studies, as well as the following case report, demonstrate its usefulness, effectiveness, and safety in a carefully selected group of patients. In this particular instance, even a third SBRT course has been demonstrated to yield clinical benefits and can be executed safely, provided that it is administered in accordance with proper technical regimens and critical organ sparing strategies.
SN  - 2234-943X
ER  -