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Peer-reviewedCC BYRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo

Umbilical cord blood miR-125b-5p: a diagnostic and prognostic biomarker for neonatal respiratory distress syndrome.

  • Yang Zhang1
  • Zhiqiang Liu1
  • Yanchun Zhang1
  • Yanan Hou1
  • Lushuang Sun1
  1. 1Shengli Oilfield Central Hospital, Shandong, China.
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Abstract

Objective

Neonatal respiratory distress syndrome (NRDS) is a common respiratory disease. This study aimed to detect the expression of miR-125b-5p in the umbilical cord blood of NRDS patients and to evaluate its diagnostic and prognostic value.Methods

Fluorescence-based real-time quantitative polymerase chain reaction was used to detect miR-125b-5p expression in the umbilical cord blood of NRDS patients and controls. The correlation between miR-125b-5p expression and NRDS clinical data was analyzed. Survival was analyzed using the Kaplan-Meier method. Cox regression identified risk factors for adverse outcomes, and the ROC curve evaluated diagnostic and prognostic accuracy.Results

The level of miR-125b-5p in NRDS patients was higher than that in controls. High miR-125b-5p expression was correlated with C-reactive protein levels, umbilical artery blood gas parameters, and the lung ultrasound score. Patients with high miR-125b-5p expression had significantly shorter event-free survival (HR 2.358, 95%CI 1.345-4.133, p<0.05) and long-term survival (HR 2.489, 95%CI 1.201-5.161, p<0.05). Cox regression identified high miR-125b-5p expression, high lung ultrasound score, high PaCO₂, and high PaO₂ as prognostic factors.Conclusions

Umbilical cord blood miR-125b-5p is highly expressed in NRDS. It may serve as a biomarker for the diagnosis and prognosis of NRDS.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026umbilical,
  title = {{Umbilical cord blood miR-125b-5p: a diagnostic and prognostic biomarker for neonatal respiratory distress syndrome.}},
  author = {Yang Zhang and Zhiqiang Liu and Yanchun Zhang and Yanan Hou and Lushuang Sun},
  journal = {Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo},
  year = {2026},
  month = oct,
  doi = {10.1590/1984-0462/2026/44/2025344},
  url = {https://europepmc.org/article/MED/42912063},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Umbilical cord blood miR-125b-5p: a diagnostic and prognostic biomarker for neonatal respiratory distress syndrome.
AU  - Yang Zhang
AU  - Zhiqiang Liu
AU  - Yanchun Zhang
AU  - Yanan Hou
AU  - Lushuang Sun
PY  - 2026
DA  - 2026/10/19
JO  - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
DO  - 10.1590/1984-0462/2026/44/2025344
UR  - https://europepmc.org/article/MED/42912063
AB  - Objective  Neonatal respiratory distress syndrome (NRDS) is a common respiratory disease. This study aimed to detect the expression of miR-125b-5p in the umbilical cord blood of NRDS patients and to evaluate its diagnostic and prognostic value.Methods  Fluorescence-based real-time quantitative polymerase chain reaction was used to detect miR-125b-5p expression in the umbilical cord blood of NRDS patients and controls. The correlation between miR-125b-5p expression and NRDS clinical data was analyzed. Survival was analyzed using the Kaplan-Meier method. Cox regression identified risk factors for adverse outcomes, and the ROC curve evaluated diagnostic and prognostic accuracy.Results  The level of miR-125b-5p in NRDS patients was higher than that in controls. High miR-125b-5p expression was correlated with C-reactive protein levels, umbilical artery blood gas parameters, and the lung ultrasound score. Patients with high miR-125b-5p expression had significantly shorter event-free survival (HR 2.358, 95%CI 1.345-4.133, p<0.05) and long-term survival (HR 2.489, 95%CI 1.201-5.161, p<0.05). Cox regression identified high miR-125b-5p expression, high lung ultrasound score, high PaCO₂, and high PaO₂ as prognostic factors.Conclusions  Umbilical cord blood miR-125b-5p is highly expressed in NRDS. It may serve as a biomarker for the diagnosis and prognosis of NRDS.
SN  - 0103-0582
SN  - 1984-0462
ER  -