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Peer-reviewedCC BY 4.0International Journal of Hypertension

Association of Platelet‐to‐White Blood Cell Ratio With All‐Cause and Cardiovascular Mortality in Hypertensive Patients

  • Yuqin Xiong1
  • Han Qian2
  • Qimei Zong2
  1. 1The First Affiliated Hospital of Xiamen University Xiamen Fujian China xmu.edu.cn
  2. 2Department of Cardiology The First People’s Hospital of Taicang Taicang Affiliated Hospital of Soochow University Taicang Jiangsu China suda.edu.cn
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Abstract

Introduction: This study investigates the prognostic value of the platelet‐to‐white blood cell ratio (PWR), a composite inflammatory indicator derived from routine complete blood count parameters, for all‐cause and cardiovascular mortality in hypertensive populations.

Methods: A retrospective cohort analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) database spanning 1999–2018. The study included 21,608 hypertensive participants aged ≥ 20 years with complete PWR measurements and mortality follow‐up data. Cox proportional hazards regression models were employed to assess associations between PWR and mortality. Restricted cubic splines identified nonlinear relationships, and time‐dependent receiver operating characteristic (ROC) curves evaluated predictive performance.

Results: An inverse association was observed between PWR and mortality risk in hypertensive patients. Each standard deviation increase in PWR was associated with a 10.0% reduction in all‐cause mortality (HR = 0.900, 95% CI: 0.873–0.927, p < 0.001) and a 12.3% reduction in cardiovascular mortality (HR = 0.877, 95% CI: 0.828–0.930, p < 0.001) in fully adjusted models. A characteristic L‐shaped nonlinear relationship was identified, with inflection points at PWR 45.22 for all‐cause mortality and PWR 50.59 for cardiovascular mortality. Time‐dependent ROC analysis also demonstrated modest discriminatory capacity.

Conclusion: This study suggests that PWR might be a potential biomarker for stratifying risk and predicting mortality in hypertensive patients.

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Cite

BibTeXRIS
BibTeX
@article{xiong2026association,
  title = {{Association of Platelet‐to‐White Blood Cell Ratio With All‐Cause and Cardiovascular Mortality in Hypertensive Patients}},
  author = {Yuqin Xiong and Han Qian and Qimei Zong},
  journal = {International Journal of Hypertension},
  year = {2026},
  month = nov,
  doi = {10.1155/ijhy/2913197},
  url = {https://doi.org/10.1155/ijhy/2913197},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association of Platelet‐to‐White Blood Cell Ratio With All‐Cause and Cardiovascular Mortality in Hypertensive Patients
AU  - Yuqin Xiong
AU  - Han Qian
AU  - Qimei Zong
PY  - 2026
DA  - 2026/11/01
JO  - International Journal of Hypertension
DO  - 10.1155/ijhy/2913197
UR  - https://doi.org/10.1155/ijhy/2913197
AB  - Introduction: This study investigates the prognostic value of the platelet‐to‐white blood cell ratio (PWR), a composite inflammatory indicator derived from routine complete blood count parameters, for all‐cause and cardiovascular mortality in hypertensive populations.  Methods: A retrospective cohort analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) database spanning 1999–2018. The study included 21,608 hypertensive participants aged ≥ 20 years with complete PWR measurements and mortality follow‐up data. Cox proportional hazards regression models were employed to assess associations between PWR and mortality. Restricted cubic splines identified nonlinear relationships, and time‐dependent receiver operating characteristic (ROC) curves evaluated predictive performance.  Results: An inverse association was observed between PWR and mortality risk in hypertensive patients. Each standard deviation increase in PWR was associated with a 10.0% reduction in all‐cause mortality (HR = 0.900, 95% CI: 0.873–0.927, p < 0.001) and a 12.3% reduction in cardiovascular mortality (HR = 0.877, 95% CI: 0.828–0.930, p < 0.001) in fully adjusted models. A characteristic L‐shaped nonlinear relationship was identified, with inflection points at PWR 45.22 for all‐cause mortality and PWR 50.59 for cardiovascular mortality. Time‐dependent ROC analysis also demonstrated modest discriminatory capacity.  Conclusion: This study suggests that PWR might be a potential biomarker for stratifying risk and predicting mortality in hypertensive patients.
SN  - 2090-0384
SN  - 2090-0392
ER  -