Carbapenem resistance in pediatric Acinetobacter baumannii urinary tract infections: molecular determinants.
4 affiliations
- 1Pediatrics- Faculty of Medicine, Mansoura University, Mansoura, Egypt.
- 2Clinical Pathology-Faculty of Medicine, Mansoura University, Mansoura, Egypt. [email protected].
- 3Clinical Pathology-Faculty of Medicine, Mansoura University, Mansoura, Egypt.
- 4Department of Pediatrics, Horus University Faculty of Medicine, Damietta, Egypt.
Abstract
Background
In the pediatric population, carbapenem-resistant Acinetobacter baumannii (CRAB) is a significant cause of hospital-acquired infections, particularly hospital-acquired urinary tract infections (HA-UTIs). There are a few studies on the molecular mechanisms of resistance to CRAB among children.Objective
To detect the prevalence of CRAB among children with HA-UTIs and to evaluate associated carbapenemase genes and clinical risk factors.Methods
This cross-sectional study included 100 children with HA-UTIs. Isolates were identified using standard microbiology techniques, and antimicrobial resistance (AMR) was detected according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Carbapenemase genes (blaOXA-23-like, blaOXA-24/40-like, blaOXA-58-like, and blaNDM) were detected by PCR. Data were statistically analyzed to assess the association between clinical factors and carbapenem resistance (CR).Results
CR was identified in 73% of isolates. High rates of AMR were observed for cephalosporins and fluoroquinolones. The most prevalent gene was the blaOXA-23-like gene (60%), followed by the blaOXA-58-like (34%), the blaOXA-24/40-like (30%), and the blaNDM (15%). A significant association was observed between resistance to carbapenems and the carbapenemase genes blaOXA-23-like and blaNDM (p < 0.05). Clinical factors like ICU admission and catheterization did not show a significant association with resistance.Conclusion
Carbapenem resistance among pediatric Acinetobacter baumannii UTIs is highly prevalent and primarily driven by molecular mechanisms, particularly OXA-23 and NDM carbapenemases. This underscores the significance of molecular diagnostics and infection control in pediatric healthcare settings.
Related
- Cost-Effectiveness of Sulbactam-durlobactam Compared with Colistin for Treating Carbapenem-Resistant Acinetobacter baumannii Infections in Critical Care Settings in the United States
- Carbapenem-resistant Acinetobacter baumannii infections in intensive care units: incidence, infection prevention and control, and antimicrobial stewardship practices in the cross-border region between Italy and France, 2019–2022
- Risk factors, molecular features, and antibiotic susceptibility in carbapenem-resistant Enterobacterales infections among pediatric patients: a matched case-control study
- Beyond Resistance: Carbapenemase Gene Profiles and Mortality in ICU Patients with Carbapenem-Resistant Klebsiella pneumoniae Infections
- Outbreak of carbapenem-resistant Acinetobacter baumannii in post–haematopoietic stem cell transplantation patients potentially caused by drinking water contamination
BibTeX
@article{hassan2026carbapenem,
title = {{Carbapenem resistance in pediatric Acinetobacter baumannii urinary tract infections: molecular determinants.}},
author = {Rasha Hassan Hassan and Maysaa El Sayed Zaki and Mohamed Saleh Ismail and Mohamed Ahmed Noureldin and Nourhan Alaa El-Din Youssef},
journal = {Italian journal of pediatrics},
year = {2026},
month = nov,
doi = {10.1186/s13052-026-02349-9},
url = {https://europepmc.org/article/MED/42972474},
note = {CC BY},
}
RIS
TY - JOUR
TI - Carbapenem resistance in pediatric Acinetobacter baumannii urinary tract infections: molecular determinants.
AU - Rasha Hassan Hassan
AU - Maysaa El Sayed Zaki
AU - Mohamed Saleh Ismail
AU - Mohamed Ahmed Noureldin
AU - Nourhan Alaa El-Din Youssef
PY - 2026
DA - 2026/11/02
JO - Italian journal of pediatrics
DO - 10.1186/s13052-026-02349-9
UR - https://europepmc.org/article/MED/42972474
AB - Background In the pediatric population, carbapenem-resistant Acinetobacter baumannii (CRAB) is a significant cause of hospital-acquired infections, particularly hospital-acquired urinary tract infections (HA-UTIs). There are a few studies on the molecular mechanisms of resistance to CRAB among children.Objective To detect the prevalence of CRAB among children with HA-UTIs and to evaluate associated carbapenemase genes and clinical risk factors.Methods This cross-sectional study included 100 children with HA-UTIs. Isolates were identified using standard microbiology techniques, and antimicrobial resistance (AMR) was detected according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Carbapenemase genes (blaOXA-23-like, blaOXA-24/40-like, blaOXA-58-like, and blaNDM) were detected by PCR. Data were statistically analyzed to assess the association between clinical factors and carbapenem resistance (CR).Results CR was identified in 73% of isolates. High rates of AMR were observed for cephalosporins and fluoroquinolones. The most prevalent gene was the blaOXA-23-like gene (60%), followed by the blaOXA-58-like (34%), the blaOXA-24/40-like (30%), and the blaNDM (15%). A significant association was observed between resistance to carbapenems and the carbapenemase genes blaOXA-23-like and blaNDM (p < 0.05). Clinical factors like ICU admission and catheterization did not show a significant association with resistance.Conclusion Carbapenem resistance among pediatric Acinetobacter baumannii UTIs is highly prevalent and primarily driven by molecular mechanisms, particularly OXA-23 and NDM carbapenemases. This underscores the significance of molecular diagnostics and infection control in pediatric healthcare settings.
SN - 1824-7288
ER -