Retrospective study: preoperative MRI features for predicting microvascular decompression outcomes in trigeminal neuralgia.
- 1Department of Neurosurgery, Jining No.1 People's Hospital, No. 269 Mengzi Avenue, High Tech Zone, Jining City, Shandong Province, 272073, China.
- 2Department of Neurosurgery, Jining No.1 People's Hospital, No. 269 Mengzi Avenue, High Tech Zone, Jining City, Shandong Province, 272073, China. [email protected].
Abstract
Objective
To develop and internally validate machine learning models based on preoperative magnetic resonance imaging (MRI) features for predicting MVD treatment outcomes in TN patients.Methods
This retrospective single-center study included 100 patients with TN who underwent primary MVD surgery between January 2020 and December 2024. Preoperative high-resolution MRI sequences including 3D-T2 and time-of-flight magnetic resonance angiography (TOF-MRA) were analyzed. Imaging features included neurovascular compression (NVC) characteristics, nerve morphology, anatomical measurements, and radiomics features. Multiple machine learning algorithms including logistic regression, support vector machine, random forest, and gradient boosting were developed and internally validated using 10-fold cross-validation. All feature preprocessing and selection steps (correlation pruning, univariate analysis, recursive feature elimination) were performed within each training fold of the cross-validation framework to eliminate information leakage. The effective number of predictors after selection and event per predictor (EPP) ratio were calculated to assess overfitting risk associated with class imbalance.Results
Complete pain relief was achieved in 93% of patients at final follow-up. The gradient boosting model demonstrated the best predictive performance with an area under the curve (AUC) of 0.847 (95% CI: 0.752-0.925), accuracy of 82.3%, sensitivity of 78.6%, and specificity of 87.5%. Calibration analysis for the gradient boosting model demonstrated a calibration intercept of 0.08 and calibration slope of 0.94, with a Brier score of 0.127 (95% CI: 0.089-0.176), indicating excellent agreement between predicted and observed outcomes. The most important predictive features included NVC severity grade (importance: 0.234), neurovascular angle (importance: 0.187), nerve atrophy presence (importance: 0.156), arterial compression type (importance: 0.142), and proximal NVC location (importance: 0.128). This univariate significance of NVC severity grade (p = 0.003) was consistent with its top ranking in SHAP feature importance analysis, validating the robustness of this key predictive feature. Patients with severe NVC (grade 2) had significantly higher success rates compared to mild NVC (96.4% vs. 76.2%, p = 0.003).Conclusion
Machine learning models integrating preoperative MRI features can accurately predict MVD surgical outcomes in TN patients. SHapley Additive exPlanations (SHAP) values provide minimal interpretability for these models, offering basic insight into feature contribution without establishing causal relationships or actionable clinical causality. These predictive models may facilitate personalized treatment planning, improve patient counseling, and optimize surgical decision-making within the evolving framework of precision neurosurgical care and Enhanced Recovery After Surgery (ERAS) protocols. Prospective external validation in multi-center cohorts is urgently required to confirm model generalizability before routine clinical implementation.
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BibTeX
@article{chen2026retrospective,
title = {{Retrospective study: preoperative MRI features for predicting microvascular decompression outcomes in trigeminal neuralgia.}},
author = {Fei Chen and Dandan Shang and Dengbin Sun and Zhaoping Wang},
journal = {BMC medical informatics and decision making},
year = {2026},
month = aug,
doi = {10.1186/s12911-026-03745-1},
url = {https://europepmc.org/article/MED/42958297},
note = {CC BY},
}
RIS
TY - JOUR
TI - Retrospective study: preoperative MRI features for predicting microvascular decompression outcomes in trigeminal neuralgia.
AU - Fei Chen
AU - Dandan Shang
AU - Dengbin Sun
AU - Zhaoping Wang
PY - 2026
DA - 2026/08/03
JO - BMC medical informatics and decision making
DO - 10.1186/s12911-026-03745-1
UR - https://europepmc.org/article/MED/42958297
AB - Objective To develop and internally validate machine learning models based on preoperative magnetic resonance imaging (MRI) features for predicting MVD treatment outcomes in TN patients.Methods This retrospective single-center study included 100 patients with TN who underwent primary MVD surgery between January 2020 and December 2024. Preoperative high-resolution MRI sequences including 3D-T2 and time-of-flight magnetic resonance angiography (TOF-MRA) were analyzed. Imaging features included neurovascular compression (NVC) characteristics, nerve morphology, anatomical measurements, and radiomics features. Multiple machine learning algorithms including logistic regression, support vector machine, random forest, and gradient boosting were developed and internally validated using 10-fold cross-validation. All feature preprocessing and selection steps (correlation pruning, univariate analysis, recursive feature elimination) were performed within each training fold of the cross-validation framework to eliminate information leakage. The effective number of predictors after selection and event per predictor (EPP) ratio were calculated to assess overfitting risk associated with class imbalance.Results Complete pain relief was achieved in 93% of patients at final follow-up. The gradient boosting model demonstrated the best predictive performance with an area under the curve (AUC) of 0.847 (95% CI: 0.752-0.925), accuracy of 82.3%, sensitivity of 78.6%, and specificity of 87.5%. Calibration analysis for the gradient boosting model demonstrated a calibration intercept of 0.08 and calibration slope of 0.94, with a Brier score of 0.127 (95% CI: 0.089-0.176), indicating excellent agreement between predicted and observed outcomes. The most important predictive features included NVC severity grade (importance: 0.234), neurovascular angle (importance: 0.187), nerve atrophy presence (importance: 0.156), arterial compression type (importance: 0.142), and proximal NVC location (importance: 0.128). This univariate significance of NVC severity grade (p = 0.003) was consistent with its top ranking in SHAP feature importance analysis, validating the robustness of this key predictive feature. Patients with severe NVC (grade 2) had significantly higher success rates compared to mild NVC (96.4% vs. 76.2%, p = 0.003).Conclusion Machine learning models integrating preoperative MRI features can accurately predict MVD surgical outcomes in TN patients. SHapley Additive exPlanations (SHAP) values provide minimal interpretability for these models, offering basic insight into feature contribution without establishing causal relationships or actionable clinical causality. These predictive models may facilitate personalized treatment planning, improve patient counseling, and optimize surgical decision-making within the evolving framework of precision neurosurgical care and Enhanced Recovery After Surgery (ERAS) protocols. Prospective external validation in multi-center cohorts is urgently required to confirm model generalizability before routine clinical implementation.
SN - 1472-6947
ER -