Negative Emotions Induce Urticaria by Regulating Metabolites: A Two-Step Mendelian Randomization Study.
- 1Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
- 2Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Abstract
Introduction
Several studies have indicated a potential link between emotions and urticaria. However, the causal relationship between different emotions and urticaria and its subtypes, as well as whether circulating metabolites act as mediators, remains unclear.Objectives
To investigate the causal relationships between negative emotions, circulating metabolites, and urticaria and its subtypes, and to assess the mediating effects of circulating metabolites.Methods
Instrumental variables for eight negative emotions, 1400 circulating metabolic factors, and urticaria were sourced from publicly available GWAS summary data. We used Mendelian randomization (MR) to explore the causal links between emotions, circulating metabolites, and urticaria, utilizing inverse variance weighting (IVW) as the main statistical approach.Result
The MR analysis results showed that nervous feelings (P=0.046; 95% CI:1.02-7.65) and worrier/anxious feelings (P=0.016; 95% CI:1.17-4.60) may be risk factors of urticaria. In addition, we found that 17 metabolites and three metabolite ratios increased the risk of urticaria, while 18 metabolites and two metabolite ratios were protective factors.Conclusion
The mediating MR analysis revealed that worrier/anxious feelings increase urticaria risk by decreasing mannose, mannonate, and glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)) levels and by increasing the phosphate-to-mannose ratio and glucose-to-mannose ratio. However, the relationship between nervous feelings and urticaria is not mediated by metabolites. These findings provide new perspectives and potential strategies for the comprehensive prevention and treatment of urticaria through emotional and metabolic interventions.
Related
- Genetically Proxied SGLT2 Inhibition and Risk of Epilepsy: A Mediation Mendelian Randomization Study of Circulating Metabolites
- Identification of Genes Associated with Gut Microbiota Metabolites in Type 2 Diabetes Mellitus Complicated by Acute Cerebral Infarction Based on Bioinformatics and Mendelian Randomization
- Abdominal Adiposity and Lacunar Stroke: A Mendelian Randomization Mediation Study
- Stroke and brain white/gray matter alterations : A Mendelian randomization investigation
- Causal effects of educational attainment on respiratory diseases : A Mendelian randomization study
BibTeX
@article{zhang2026negative,
title = {{Negative Emotions Induce Urticaria by Regulating Metabolites: A Two-Step Mendelian Randomization Study.}},
author = {Keyi Zhang and Yibo Hu and Li Lei and Chuhan Fu and Shu Zhou and Yaqing Wen and Jiangfeng Huang and Jinhua Huang and Jing Chen and Qinghai Zeng},
journal = {Dermatology practical \& conceptual},
year = {2026},
month = jul,
doi = {10.5826/dpc.1603a6592},
url = {https://europepmc.org/article/MED/42858389},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Negative Emotions Induce Urticaria by Regulating Metabolites: A Two-Step Mendelian Randomization Study.
AU - Keyi Zhang
AU - Yibo Hu
AU - Li Lei
AU - Chuhan Fu
AU - Shu Zhou
AU - Yaqing Wen
AU - Jiangfeng Huang
AU - Jinhua Huang
AU - Jing Chen
AU - Qinghai Zeng
PY - 2026
DA - 2026/07/31
JO - Dermatology practical & conceptual
DO - 10.5826/dpc.1603a6592
UR - https://europepmc.org/article/MED/42858389
AB - Introduction Several studies have indicated a potential link between emotions and urticaria. However, the causal relationship between different emotions and urticaria and its subtypes, as well as whether circulating metabolites act as mediators, remains unclear.Objectives To investigate the causal relationships between negative emotions, circulating metabolites, and urticaria and its subtypes, and to assess the mediating effects of circulating metabolites.Methods Instrumental variables for eight negative emotions, 1400 circulating metabolic factors, and urticaria were sourced from publicly available GWAS summary data. We used Mendelian randomization (MR) to explore the causal links between emotions, circulating metabolites, and urticaria, utilizing inverse variance weighting (IVW) as the main statistical approach.Result The MR analysis results showed that nervous feelings (P=0.046; 95% CI:1.02-7.65) and worrier/anxious feelings (P=0.016; 95% CI:1.17-4.60) may be risk factors of urticaria. In addition, we found that 17 metabolites and three metabolite ratios increased the risk of urticaria, while 18 metabolites and two metabolite ratios were protective factors.Conclusion The mediating MR analysis revealed that worrier/anxious feelings increase urticaria risk by decreasing mannose, mannonate, and glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)) levels and by increasing the phosphate-to-mannose ratio and glucose-to-mannose ratio. However, the relationship between nervous feelings and urticaria is not mediated by metabolites. These findings provide new perspectives and potential strategies for the comprehensive prevention and treatment of urticaria through emotional and metabolic interventions.
SN - 2160-9381
ER -