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Peer-reviewedCC BYHematology, Transfusion and Cell Therapy

PREOPERATIVE HEMOGLOBIN AS A PREDICTOR OF TRANSFUSION REQUIREMENT IN PATIENTS UNDERGOING ELECTIVE HIP ARTHROPLASTY

1 more authors
4 affiliations
  1. 1Universidade Federal do Amazonas (UFAM), Manaus, Brazil
  2. 2Universidade Estadual do Amazonas (UEA), Manaus, Brazil
  3. 3Fundação Hospital Adriano Jorge (FHAJ), Manaus, Brazil
  4. 4Faculdade Metropolitana de Manaus (FAMETRO), Manaus, Brazil

Abstract

Introduction: Preoperative anemia is one of the main factors associated with transfusion requirements in major orthopedic surgery. Early identification of patients at higher transfusion risk enables the implementation of Patient Blood Management (PBM) strategies aimed at preoperative optimization and the rational use of blood components. However, national data on the predictive ability of preoperative hemoglobin for transfusion requirements in elective hip arthroplasty remain limited. Objectives: To evaluate the predictive performance of preoperative hemoglobin for transfusion requirements in patients undergoing elective hip arthroplasty. Materials and methods: This retrospective observational study was conducted at Fundação Hospital Adriano Jorge (FHAJ), a tertiary referral hospital in the Brazilian Amazon region, including patients who underwent elective hip arthroplasty between 2024 and 2025. A total of 129 patients were identified, of whom 73 with available preoperative hemoglobin records were included in the analysis. Hemoglobin distribution was assessed using the Shapiro–Wilk test. Mean values were compared using Student’s t-test. The association between preoperative hemoglobin and transfusion requirement was analyzed using binary logistic regression, and predictive performance was evaluated by receiver operating characteristic (ROC) curve analysis. Statistical analyses were performed using Python software version 3.12.5, adopting a significance level of 5%. Results: Patients who required transfusion had significantly lower mean preoperative hemoglobin levels than those who did not receive transfusion (11.50 ± 2.33 vs. 13.46 ± 1.62 g/dL; mean difference, 1.96 g/dL; 95% CI, 0.94–2.99; p = 0.0003). In the logistic regression, each 1 g/dL increase in preoperative hemoglobin was associated with an approximately 44% reduction in the odds of transfusion (OR = 0.56; 95% CI, 0.40–0.80; p = 0.001). Preoperative hemoglobin demonstrated moderate discriminatory ability for predicting transfusion requirement (AUC = 0.77; 95% CI, 0.59–0.92; p = 0.0004), with a cutoff of ≤10.9 g/dL (sensitivity, 60.0%; specificity, 93.1%). Discussion and conclusion: The results demonstrate that lower preoperative hemoglobin levels were associated with transfusion requirements, highlighting their potential as a preoperative risk marker in patients undergoing elective hip arthroplasty. The observed discriminatory ability, together with the identified cutoff, may assist in transfusion risk stratification and in guiding PBM strategies. Therefore, incorporating preoperative hemoglobin into the preoperative assessment may contribute to transfusion support planning and to the implementation of PBM strategies in patients undergoing elective hip arthroplasty.

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BibTeX
@article{ferreiragomes2026preoperative,
  title = {{PREOPERATIVE HEMOGLOBIN AS A PREDICTOR OF TRANSFUSION REQUIREMENT IN PATIENTS UNDERGOING ELECTIVE HIP ARTHROPLASTY}},
  author = {Ricardo FERREIRA-GOMES and Erick Frota Gomes Ricardo FIGUEIREDO and Greice Mariana THOMAZ-BARBOSA and Thais Caroline Torres RIBEIRO and Eduarda da Costa QUEIROZ DA SILVA and Odvania Mendes de MELO and Adriana Gomes RODRIGUES FEITOZA and Lailla Melissa Castro MORAES and Antonia Gerarda PAMELLA REIMERS and Eliane Aparecida PEIXOTO PAULO and Robson Luís Oliveira AMORIM and Silvânia da Conceição FURTADO and Bruno Bellaguarda BATISTA},
  journal = {Hematology, Transfusion and Cell Therapy},
  year = {2026},
  month = oct,
  doi = {10.1016/j.htct.2026.107387},
  url = {https://doi.org/10.1016/j.htct.2026.107387},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - PREOPERATIVE HEMOGLOBIN AS A PREDICTOR OF TRANSFUSION REQUIREMENT IN PATIENTS UNDERGOING ELECTIVE HIP ARTHROPLASTY
AU  - Ricardo FERREIRA-GOMES
AU  - Erick Frota Gomes Ricardo FIGUEIREDO
AU  - Greice Mariana THOMAZ-BARBOSA
AU  - Thais Caroline Torres RIBEIRO
AU  - Eduarda da Costa QUEIROZ DA SILVA
AU  - Odvania Mendes de MELO
AU  - Adriana Gomes RODRIGUES FEITOZA
AU  - Lailla Melissa Castro MORAES
AU  - Antonia Gerarda PAMELLA REIMERS
AU  - Eliane Aparecida PEIXOTO PAULO
AU  - Robson Luís Oliveira AMORIM
AU  - Silvânia da Conceição FURTADO
AU  - Bruno Bellaguarda BATISTA
PY  - 2026
DA  - 2026/10/23
JO  - Hematology, Transfusion and Cell Therapy
DO  - 10.1016/j.htct.2026.107387
UR  - https://doi.org/10.1016/j.htct.2026.107387
AB  - Introduction: Preoperative anemia is one of the main factors associated with transfusion requirements in major orthopedic surgery. Early identification of patients at higher transfusion risk enables the implementation of Patient Blood Management (PBM) strategies aimed at preoperative optimization and the rational use of blood components. However, national data on the predictive ability of preoperative hemoglobin for transfusion requirements in elective hip arthroplasty remain limited. Objectives: To evaluate the predictive performance of preoperative hemoglobin for transfusion requirements in patients undergoing elective hip arthroplasty. Materials and methods: This retrospective observational study was conducted at Fundação Hospital Adriano Jorge (FHAJ), a tertiary referral hospital in the Brazilian Amazon region, including patients who underwent elective hip arthroplasty between 2024 and 2025. A total of 129 patients were identified, of whom 73 with available preoperative hemoglobin records were included in the analysis. Hemoglobin distribution was assessed using the Shapiro–Wilk test. Mean values were compared using Student’s t-test. The association between preoperative hemoglobin and transfusion requirement was analyzed using binary logistic regression, and predictive performance was evaluated by receiver operating characteristic (ROC) curve analysis. Statistical analyses were performed using Python software version 3.12.5, adopting a significance level of 5%. Results: Patients who required transfusion had significantly lower mean preoperative hemoglobin levels than those who did not receive transfusion (11.50 ± 2.33 vs. 13.46 ± 1.62 g/dL; mean difference, 1.96 g/dL; 95% CI, 0.94–2.99; p = 0.0003). In the logistic regression, each 1 g/dL increase in preoperative hemoglobin was associated with an approximately 44% reduction in the odds of transfusion (OR = 0.56; 95% CI, 0.40–0.80; p = 0.001). Preoperative hemoglobin demonstrated moderate discriminatory ability for predicting transfusion requirement (AUC = 0.77; 95% CI, 0.59–0.92; p = 0.0004), with a cutoff of ≤10.9 g/dL (sensitivity, 60.0%; specificity, 93.1%). Discussion and conclusion: The results demonstrate that lower preoperative hemoglobin levels were associated with transfusion requirements, highlighting their potential as a preoperative risk marker in patients undergoing elective hip arthroplasty. The observed discriminatory ability, together with the identified cutoff, may assist in transfusion risk stratification and in guiding PBM strategies. Therefore, incorporating preoperative hemoglobin into the preoperative assessment may contribute to transfusion support planning and to the implementation of PBM strategies in patients undergoing elective hip arthroplasty.
SN  - 2531-1379
SN  - 2531-1387
ER  -