Nanotechnology to Engineer the Surface of Immune Cells.
- 1Department of Bioengineering, Rice University, Houston, Texas 77030, United States.
Abstract
Attaching nanomaterials onto the surface of immune cells to modulate immune responses or enable tissue-specific drug delivery represents an emerging area of biomedical research with state-of-the-art technological advances and promising therapeutic outcomes. Biocompatible nanomaterials can be conjugated to immune cell surfaces ex vivo for adoptive cell therapies or selectively targeted to specific subpopulations of immune cells in vivo following systemic or local administration. Over the past 15 years, sustained efforts have yielded several robust platforms that rationally integrate appropriate physicochemical and biological properties of nanomaterials with the specialized functional attributes of immune cells, resulting in previously unanticipated therapeutic effects. In this review, we summarize recent advances in this field, including engineering methodologies and associated therapeutic effects, organized by the type of surface engineering approach. We anticipate that continued progress in this area will offer new therapeutic opportunities for diseases that lack effective treatment.
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BibTeX
@article{zhang2026nanotechnology,
title = {{Nanotechnology to Engineer the Surface of Immune Cells.}},
author = {Zhenjiang Zhang and Michael R King},
journal = {ACS nanoscience Au},
year = {2026},
month = aug,
doi = {10.1021/acsnanoscienceau.6c00056},
url = {https://europepmc.org/article/MED/42921329},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Nanotechnology to Engineer the Surface of Immune Cells.
AU - Zhenjiang Zhang
AU - Michael R King
PY - 2026
DA - 2026/08/18
JO - ACS nanoscience Au
DO - 10.1021/acsnanoscienceau.6c00056
UR - https://europepmc.org/article/MED/42921329
AB - Attaching nanomaterials onto the surface of immune cells to modulate immune responses or enable tissue-specific drug delivery represents an emerging area of biomedical research with state-of-the-art technological advances and promising therapeutic outcomes. Biocompatible nanomaterials can be conjugated to immune cell surfaces ex vivo for adoptive cell therapies or selectively targeted to specific subpopulations of immune cells in vivo following systemic or local administration. Over the past 15 years, sustained efforts have yielded several robust platforms that rationally integrate appropriate physicochemical and biological properties of nanomaterials with the specialized functional attributes of immune cells, resulting in previously unanticipated therapeutic effects. In this review, we summarize recent advances in this field, including engineering methodologies and associated therapeutic effects, organized by the type of surface engineering approach. We anticipate that continued progress in this area will offer new therapeutic opportunities for diseases that lack effective treatment.
SN - 2694-2496
ER -