Dlx1&2 directly promote expression of Cxcl14 to control synapse development and interneuron survival
4 affiliations
- 1Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA 94143
- 2Department of Neurobiology, Physiology, and Behavior, Center for Neuroscience, University of California Davis, Davis, CA 95618
- 3Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, University of California Davis, Davis, CA 95618
- 4Allen Institute for Brain Science, Seattle, WA 98109
Abstract
Dlx genes have fundamental roles in the generation, differentiation, and functions of virtually all forebrain GABAergic neurons. Here we used scRNA-Seq to identify genes that are dysregulated in Dlx1/2 conditional mutants in mouse immature CGE- and MGE-derived cortical and olfactory bulb GABAergic interneurons. Dlx1/2-regulated genes included Cxcl14 and Nr2f2 that are important for cortical interneuron (CIN) survival. We also identified DLX2-bound putative regulatory elements (pREs) of these Dlx-regulated genes. Within the Dlx-expressing lineage, some DLX-bound pREs were specific to CINs, others appeared to be constitutively bound; the latter class having activity in mature CINs. One such pRE and its associated gene, Cxcl14, is strongly activated by Dlx1/2 and is essential for synaptogenesis onto CINs.
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BibTeX
@article{guo2026dlx12,
title = {{Dlx1&2 directly promote expression of Cxcl14 to control synapse development and interneuron survival}},
author = {Teng Guo and Susan Lindtner and Jia Sheng Hu and Siavash Fazel Darbandi and Yurong Wang and Emily Ling-Lin Pai and Athéna R. Ypsilanti and Cindy T. J. van Velthoven and Alex S. Nord and John L. R. Rubenstein},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = oct,
doi = {10.1073/pnas.2616055123},
url = {https://doi.org/10.1073/pnas.2616055123},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Dlx1&2 directly promote expression of Cxcl14 to control synapse development and interneuron survival
AU - Teng Guo
AU - Susan Lindtner
AU - Jia Sheng Hu
AU - Siavash Fazel Darbandi
AU - Yurong Wang
AU - Emily Ling-Lin Pai
AU - Athéna R. Ypsilanti
AU - Cindy T. J. van Velthoven
AU - Alex S. Nord
AU - John L. R. Rubenstein
PY - 2026
DA - 2026/10/28
JO - Proceedings of the National Academy of Sciences of the United States of America
DO - 10.1073/pnas.2616055123
UR - https://doi.org/10.1073/pnas.2616055123
AB - Dlx genes have fundamental roles in the generation, differentiation, and functions of virtually all forebrain GABAergic neurons. Here we used scRNA-Seq to identify genes that are dysregulated in Dlx1/2 conditional mutants in mouse immature CGE- and MGE-derived cortical and olfactory bulb GABAergic interneurons. Dlx1/2-regulated genes included Cxcl14 and Nr2f2 that are important for cortical interneuron (CIN) survival. We also identified DLX2-bound putative regulatory elements (pREs) of these Dlx-regulated genes. Within the Dlx-expressing lineage, some DLX-bound pREs were specific to CINs, others appeared to be constitutively bound; the latter class having activity in mature CINs. One such pRE and its associated gene, Cxcl14, is strongly activated by Dlx1/2 and is essential for synaptogenesis onto CINs.
SN - 0027-8424
SN - 1091-6490
ER -