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Peer-reviewedCC BYFood and Function

Orange juice and hesperidin increase flavanone exposure without detectable short-term vascular benefits: a randomized crossover trial

  • Caroline Gilcher
  • Dragan Milenkovic
  • Marie Taillandier
  • Tatjana Ruskovska
  • Christof Björn Steingass
  • Nicolas Macian
  • Marie Anne Verny
  • Rémi Evrard
  • Bruno Pereira
  • Cécile Gladine
  • Ralf Schweiggert
  • Gisèle Pickering
1 more authors
  • Christine Morand
Open at sourceDOICite

Abstract

CON. Marked interindividual variability was observed in vascular responses and flavanone bioavailability, although treatment effects were unrelated to baseline endothelial function or flavanone exposure. Exploratory transcriptomic analyses suggested modulation of pathways involved in vascular biology following OJ and HESP. Under nutritionally realistic conditions, orange juice and hesperidin induced measurable biological engagement without detectable short-term vascular benefits, highlighting the complexity of linking flavanone exposure to functional vascular outcomes in humans.

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Cite

BibTeXRIS
BibTeX
@article{gilcher2026orange,
  title = {{Orange juice and hesperidin increase flavanone exposure without detectable short-term vascular benefits: a randomized crossover trial}},
  author = {Caroline Gilcher and Dragan Milenkovic and Marie Taillandier and Tatjana Ruskovska and Christof Björn Steingass and Nicolas Macian and Marie Anne Verny and Rémi Evrard and Bruno Pereira and Cécile Gladine and Ralf Schweiggert and Gisèle Pickering and Christine Morand},
  journal = {Food and Function},
  year = {2026},
  month = sep,
  doi = {10.1039/d6fo02778d},
  url = {https://hal.science/hal-05747247v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Orange juice and hesperidin increase flavanone exposure without detectable short-term vascular benefits: a randomized crossover trial
AU  - Caroline Gilcher
AU  - Dragan Milenkovic
AU  - Marie Taillandier
AU  - Tatjana Ruskovska
AU  - Christof Björn Steingass
AU  - Nicolas Macian
AU  - Marie Anne Verny
AU  - Rémi Evrard
AU  - Bruno Pereira
AU  - Cécile Gladine
AU  - Ralf Schweiggert
AU  - Gisèle Pickering
AU  - Christine Morand
PY  - 2026
DA  - 2026/09/11
JO  - Food and Function
DO  - 10.1039/d6fo02778d
UR  - https://hal.science/hal-05747247v1
AB  - CON. Marked interindividual variability was observed in vascular responses and flavanone bioavailability, although treatment effects were unrelated to baseline endothelial function or flavanone exposure. Exploratory transcriptomic analyses suggested modulation of pathways involved in vascular biology following OJ and HESP. Under nutritionally realistic conditions, orange juice and hesperidin induced measurable biological engagement without detectable short-term vascular benefits, highlighting the complexity of linking flavanone exposure to functional vascular outcomes in humans.
SN  - 2042-6496
ER  -