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Peer-reviewedCC BYCureus

Navigating the Unknown: A Surgical Perspective on Thoracic ALK-Positive Histiocytosis With Literature Review.

  • Ramzi Addas1
  • Ahmed Alsabban1
  • Shahad Almarwan2
  • Saud Alharbi2
  1. 1Department of Thoracic Surgery, King Abdulaziz Medical City, National Guard Hospital, Jeddah, SAU.
  2. 2Department of General Surgery, King Abdulaziz Medical City, National Guard Hospital, Jeddah, SAU.
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Abstract

Anaplastic lymphoma kinase (ALK)-positive histiocytosis (APH) is a rare disorder characterized by the accumulation of cells derived from monocyte-macrophage-dendritic cells. Thoracic APH is incredibly unusual and thus creates a diagnostic challenge. In this study, we report a case of extrapulmonary APH that was managed with mass excision, with no further treatment. Moreover, we reviewed previously published relevant adult ALK-positive histiocytosis cases, their primary management, and the disease progression.

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Cite

BibTeXRIS
BibTeX
@article{addas2026navigating,
  title = {{Navigating the Unknown: A Surgical Perspective on Thoracic ALK-Positive Histiocytosis With Literature Review.}},
  author = {Ramzi Addas and Ahmed Alsabban and Shahad Almarwan and Saud Alharbi},
  journal = {Cureus},
  year = {2026},
  month = oct,
  doi = {10.7759/cureus.117571},
  url = {https://europepmc.org/article/MED/42996679},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Navigating the Unknown: A Surgical Perspective on Thoracic ALK-Positive Histiocytosis With Literature Review.
AU  - Ramzi Addas
AU  - Ahmed Alsabban
AU  - Shahad Almarwan
AU  - Saud Alharbi
PY  - 2026
DA  - 2026/10/07
JO  - Cureus
DO  - 10.7759/cureus.117571
UR  - https://europepmc.org/article/MED/42996679
AB  - Anaplastic lymphoma kinase (ALK)-positive histiocytosis (APH) is a rare disorder characterized by the accumulation of cells derived from monocyte-macrophage-dendritic cells. Thoracic APH is incredibly unusual and thus creates a diagnostic challenge. In this study, we report a case of extrapulmonary APH that was managed with mass excision, with no further treatment. Moreover, we reviewed previously published relevant adult ALK-positive histiocytosis cases, their primary management, and the disease progression.
SN  - 2168-8184
ER  -