Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 35 min ago
Peer-reviewedCC BYNature Medicine

Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease

  • Stefano Scafa1,2,3
  • Valeria de Seta1,3
  • Ruijia Wang4,3
  • P. Lopez4,3
  • Andrea Sánchez López1,3
  • Camille Varescon1,3
  • Icare Sakr4,3
  • Nadia Bérard5
  • Léa Bole-Feysot1,3
  • Celine Deschenaux1,3
  • Ian Enderli4
  • Yohann Thenaisie1,3
15 more authors
  • Morgane Burri3
  • Frédéric Merlos3
  • Vanessa Fleury6,7
  • Benoît Wicki8
  • Ettore A. Accolla9,10
  • Andria Tziakouri10
  • Cécile A. Hubsch10
  • Mayté Castro Jiménez10
  • Julien F. Bally10
  • Alessandro Puiatti2
  • Kyuhwa Lee11
  • Henri Lorach1,3
  • Antoine Collomb‐Clerc4
  • Jocelyne Bloch1,5,4,3
  • Eduardo Martin Moraud12,13,14
14 affiliations
  1. 1Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
  2. 2Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Southern Switzerland (SUPSI), Viganello, Switzerland
  3. 3NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
  4. 4Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland
  5. 5Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
  6. 6Department of Neurology, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland
  7. 7Faculty of Medicine, University of Geneva, Geneva, Switzerland
  8. 8Department of Neurology, Hôpital du Valais, Sion, Switzerland
  9. 9Department of Neurology, Hôpital Fribourgeois, Fribourg, Switzerland
  10. 10Department of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
  11. 11Wyss Center for Bio and Neuroengineering, Geneva, Switzerland
  12. 12Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland. [email protected]
  13. 13Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. [email protected]
  14. 14NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. [email protected]
Open at sourceDOICite

Abstract

Parkinson's disease leads to a spectrum of locomotor deficits that vary in severity with the nature of daily activities and the fluctuating physiology of patients. Many of these deficits remain inadequately addressed by existing deep brain stimulation therapies that rely on activity-agnostic parameters optimized for cardinal motor symptoms. By contrast, therapies embedding activity-specific parameters have the potential to better address the entire range of symptoms. Here we expose physiological principles that enable real-time decoding of ongoing locomotor activities across motor fluctuations from the neural dynamics of the subthalamic nucleus. This decoding steered activity-dependent adaptations of deep brain stimulation therapies that improved locomotor deficits while preserving efficacy for cardinal motor symptoms across activities of daily living. Our activity-dependent framework provides a blueprint for next-generation neuromodulation therapies that continuously select parameters optimized to the behavioral context and fluctuating physiology of each patient. ClinicalTrials.gov registration NCT06791902 .

Related

  1. Adaptive deep brain stimulation for dynamic gait control in Parkinson’s disease: a randomized feasibility trial
    Kenneth H. Louie, Jannine P. Balakid, Jessica E. Bath +6
    Nature MedicinePeer-reviewedCC BYFull text15 citedNeurologyOpenAlex
  2. Unsupervised electrophysiological localization of dorsolateral-associated STN activity using an attention-based contrastive VAE for optimal deep brain stimulation electrode placement in Parkinson’s disease
    Bhavna Bajpai, Shubham Sharma, Alfredo Rosado
    Neuroscience InformaticsPeer-reviewedCC BYFull textNeurologyDOAJ
  3. Transcutaneous auricular vagus nerve stimulation demonstrates effects on pupil responses in Parkinson's disease
    L. M. Schmidt, J. Stalter, C. M. Thiel +2
    medRxivPreprintAll rights reservedFull textNeurologymedRxiv
  4. Incidental Finding of an Asymptomatic Perielectrode Cyst After Deep Brain Stimulation for Parkinson’s Disease
    Stephanie Du Four, Stijn Vandamme, Dimitri Vanhauwaert +2
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Effects of globus pallidus internus deep brain stimulation on freezing of gait in Parkinson's disease: a prospective short-term single-arm study
    Pingchen Zhang, Linghao Cao, Tengjiao Wang +5
    Frontiers in aging neurosciencePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{scafa2026activitydependent,
  title = {{Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease}},
  author = {Stefano Scafa and Valeria de Seta and Ruijia Wang and P. Lopez and Andrea Sánchez López and Camille Varescon and Icare Sakr and Nadia Bérard and Léa Bole-Feysot and Celine Deschenaux and Ian Enderli and Yohann Thenaisie and Morgane Burri and Frédéric Merlos and Vanessa Fleury and Benoît Wicki and Ettore A. Accolla and Andria Tziakouri and Cécile A. Hubsch and Mayté Castro Jiménez and Julien F. Bally and Alessandro Puiatti and Kyuhwa Lee and Henri Lorach and Antoine Collomb‐Clerc and Jocelyne Bloch and Eduardo Martin Moraud},
  journal = {Nature Medicine},
  year = {2026},
  month = jun,
  doi = {10.1038/s41591-026-04432-4},
  url = {https://hal.science/hal-05795919v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease
AU  - Stefano Scafa
AU  - Valeria de Seta
AU  - Ruijia Wang
AU  - P. Lopez
AU  - Andrea Sánchez López
AU  - Camille Varescon
AU  - Icare Sakr
AU  - Nadia Bérard
AU  - Léa Bole-Feysot
AU  - Celine Deschenaux
AU  - Ian Enderli
AU  - Yohann Thenaisie
AU  - Morgane Burri
AU  - Frédéric Merlos
AU  - Vanessa Fleury
AU  - Benoît Wicki
AU  - Ettore A. Accolla
AU  - Andria Tziakouri
AU  - Cécile A. Hubsch
AU  - Mayté Castro Jiménez
AU  - Julien F. Bally
AU  - Alessandro Puiatti
AU  - Kyuhwa Lee
AU  - Henri Lorach
AU  - Antoine Collomb‐Clerc
AU  - Jocelyne Bloch
AU  - Eduardo Martin Moraud
PY  - 2026
DA  - 2026/06/15
JO  - Nature Medicine
DO  - 10.1038/s41591-026-04432-4
UR  - https://hal.science/hal-05795919v1
AB  - Parkinson's disease leads to a spectrum of locomotor deficits that vary in severity with the nature of daily activities and the fluctuating physiology of patients. Many of these deficits remain inadequately addressed by existing deep brain stimulation therapies that rely on activity-agnostic parameters optimized for cardinal motor symptoms. By contrast, therapies embedding activity-specific parameters have the potential to better address the entire range of symptoms. Here we expose physiological principles that enable real-time decoding of ongoing locomotor activities across motor fluctuations from the neural dynamics of the subthalamic nucleus. This decoding steered activity-dependent adaptations of deep brain stimulation therapies that improved locomotor deficits while preserving efficacy for cardinal motor symptoms across activities of daily living. Our activity-dependent framework provides a blueprint for next-generation neuromodulation therapies that continuously select parameters optimized to the behavioral context and fluctuating physiology of each patient. ClinicalTrials.gov registration NCT06791902 .
SN  - 1078-8956
SN  - 1744-7933
SN  - 1546-170X
ER  -