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Peer-reviewedCC BYMicroPublication biology

Loss of the Orphan GPCR srd-44 Does Not Alter Chemotaxis of Caenorhabditis elegans to Carolina Mantle Slug Mucus.

  • Jay Garaycochea1
  • Milo Roth1
  1. 1Biological Sciences, Goucher College, Towson, MD, US.
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Abstract

C. elegans detect volatile odorants through amphid sensory neurons that express diverse G protein-coupled receptors (GPCRs), many of which remain functionally uncharacterized. We evaluated the candidate chemosensory GPCR srd-44 using the RB1526 mutant strain in chemotaxis assays against diacetyl and Carolina mantle ( Philomycus carolinianus ) slug mucus. Wild-type and mutant animals exhibited similar chemotaxis responses to both stimuli across a range of concentrations. Under these conditions, these results do not support a role for srd-44 in chemotaxis toward diacetyl or Carolina mantle slug mucus. These findings contribute to the functional evaluation of an orphan chemosensory GPCR in C. elegans .

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Cite

BibTeXRIS
BibTeX
@article{garaycochea2026loss,
  title = {{Loss of the Orphan GPCR srd-44 Does Not Alter Chemotaxis of Caenorhabditis elegans to Carolina Mantle Slug Mucus.}},
  author = {Jay Garaycochea and Milo Roth},
  journal = {MicroPublication biology},
  year = {2026},
  month = oct,
  doi = {10.17912/micropub.biology.002287},
  url = {https://europepmc.org/article/MED/42892891},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Loss of the Orphan GPCR srd-44 Does Not Alter Chemotaxis of Caenorhabditis elegans to Carolina Mantle Slug Mucus.
AU  - Jay Garaycochea
AU  - Milo Roth
PY  - 2026
DA  - 2026/10/03
JO  - MicroPublication biology
DO  - 10.17912/micropub.biology.002287
UR  - https://europepmc.org/article/MED/42892891
AB  - C. elegans detect volatile odorants through amphid sensory neurons that express diverse G protein-coupled receptors (GPCRs), many of which remain functionally uncharacterized. We evaluated the candidate chemosensory GPCR srd-44 using the RB1526 mutant strain in chemotaxis assays against diacetyl and Carolina mantle ( Philomycus carolinianus ) slug mucus. Wild-type and mutant animals exhibited similar chemotaxis responses to both stimuli across a range of concentrations. Under these conditions, these results do not support a role for srd-44 in chemotaxis toward diacetyl or Carolina mantle slug mucus. These findings contribute to the functional evaluation of an orphan chemosensory GPCR in C. elegans .
SN  - 2578-9430
ER  -