Mitophagy and Ferroptosis in Diabetic Kidney Disease: A Hypothesis of Their Synergistic Interplay in Renal Tubular Injury—A Narrative Review
- 1School of Integrative Medicine, Chongqing College of Traditional Chinese Medicine, No. 61, Guoxue Road, Bicheng Street, Bishan District, Chongqing 402760, China
- 2Foundation Department, Chongqing Medical and Pharmaceutical College, No. 82, Daxuecheng Middle Road, Shapingba District, Chongqing 401331, China
- 3Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing 402760, China
Abstract
Tubular injury induced by mitophagy or ferroptosis serves as a critical pathological basis for the progression of diabetic kidney disease (DKD). Mitophagy constitutes a critical process of mitigating tubular injury by eliminating damaged organelles to maintain cellular equilibrium and homeostasis. Ferroptosis, a form of programmed cell death characterized by lipid peroxidation, serves as a pivotal factor in the progression of DKD. While numerous studies have elucidated the complex relationship between mitophagy and ferroptosis, there is a scarcity of literature addressing the relationship between these two processes in the context of tubular damage in DKD. We reviewed recent literatures exploring the associations among mitophagy, ferroptosis, and renal tubular injury in DKD, and tried to summarize the complex crosstalk between ferroptosis and autophagy in DKD. We hope to offer some new ideas for the treatment of DKD.
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BibTeX
@article{gong2026mitophagy,
title = {{Mitophagy and Ferroptosis in Diabetic Kidney Disease: A Hypothesis of Their Synergistic Interplay in Renal Tubular Injury—A Narrative Review}},
author = {Yanyu Gong and Qiuping Liu and Hanyuan Dai and Jialing Li and Xiulin Chang and Yudi Zhang},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27198758},
url = {https://www.mdpi.com/1422-0067/27/19/8758},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Mitophagy and Ferroptosis in Diabetic Kidney Disease: A Hypothesis of Their Synergistic Interplay in Renal Tubular Injury—A Narrative Review
AU - Yanyu Gong
AU - Qiuping Liu
AU - Hanyuan Dai
AU - Jialing Li
AU - Xiulin Chang
AU - Yudi Zhang
PY - 2026
DA - 2026/09/30
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27198758
UR - https://www.mdpi.com/1422-0067/27/19/8758
AB - Tubular injury induced by mitophagy or ferroptosis serves as a critical pathological basis for the progression of diabetic kidney disease (DKD). Mitophagy constitutes a critical process of mitigating tubular injury by eliminating damaged organelles to maintain cellular equilibrium and homeostasis. Ferroptosis, a form of programmed cell death characterized by lipid peroxidation, serves as a pivotal factor in the progression of DKD. While numerous studies have elucidated the complex relationship between mitophagy and ferroptosis, there is a scarcity of literature addressing the relationship between these two processes in the context of tubular damage in DKD. We reviewed recent literatures exploring the associations among mitophagy, ferroptosis, and renal tubular injury in DKD, and tried to summarize the complex crosstalk between ferroptosis and autophagy in DKD. We hope to offer some new ideas for the treatment of DKD.
SN - 1422-0067
ER -