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Peer-reviewedCC BY 4.0Mitochondrion

Role of Coa6 in coordinating Cox2 and cytochrome c maturation in yeast mitochondria

  • Geneviève Dujardin
  • Anaïs Lalève
  • Mathilde Logerais
  • Cristina Panozzo
  • David Cornu
  • Alexa Bourand-Plantefol
  • Virginie Chiodelli
  • Patrice Hamel
  • Nathalie Bonnefoy
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Abstract

Coa6 controls copper delivery into the Cox2 subunit of the mitochondrial respiratory complex IV. Mutations in COA6 lead to Cox2 degradation and cause cardiomyopathy in humans. We show that decreasing the level of the mobile electron transporter cytochrome c improves both Cox2 accumulation and complex IV assembly in the budding yeast coa6-null mutant. As the heme attachment to apo-cytochrome c and the copper delivery to apo-Cox2 both require cysteine reduction, we propose that Coa6 plays a role in coordinating the maturation of Cox2 and Cytc with their cofactors.

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Cite

BibTeXRIS
BibTeX
@article{dujardin2026role,
  title = {{Role of Coa6 in coordinating Cox2 and cytochrome c maturation in yeast mitochondria}},
  author = {Geneviève Dujardin and Anaïs Lalève and Mathilde Logerais and Cristina Panozzo and David Cornu and Alexa Bourand-Plantefol and Virginie Chiodelli and Patrice Hamel and Nathalie Bonnefoy},
  journal = {Mitochondrion},
  year = {2026},
  month = oct,
  doi = {10.1016/j.mito.2026.102198},
  url = {https://hal.science/hal-05777232v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Role of Coa6 in coordinating Cox2 and cytochrome c maturation in yeast mitochondria
AU  - Geneviève Dujardin
AU  - Anaïs Lalève
AU  - Mathilde Logerais
AU  - Cristina Panozzo
AU  - David Cornu
AU  - Alexa Bourand-Plantefol
AU  - Virginie Chiodelli
AU  - Patrice Hamel
AU  - Nathalie Bonnefoy
PY  - 2026
DA  - 2026/10/04
JO  - Mitochondrion
DO  - 10.1016/j.mito.2026.102198
UR  - https://hal.science/hal-05777232v1
AB  - Coa6 controls copper delivery into the Cox2 subunit of the mitochondrial respiratory complex IV. Mutations in COA6 lead to Cox2 degradation and cause cardiomyopathy in humans. We show that decreasing the level of the mobile electron transporter cytochrome c improves both Cox2 accumulation and complex IV assembly in the budding yeast coa6-null mutant. As the heme attachment to apo-cytochrome c and the copper delivery to apo-Cox2 both require cysteine reduction, we propose that Coa6 plays a role in coordinating the maturation of Cox2 and Cytc with their cofactors.
SN  - 1567-7249
SN  - 1872-8278
ER  -