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Peer-reviewedCC BY-NC-ND 4.0OTO Open

Laryngeal Hypersensitivity is Correlated With Subglottic Stenosis

  • Benjamin M. Laitman1
  • Serena Pu1
  • Sandra Jardines2
  • Julia An2
  • Claire Victoria Ong1
  • Leanne Goldberg1
  • Mark Courey1
  1. 1Department of Otolaryngology – Head & Neck Surgery, Grabscheid Voice and Swallowing Center Mount Sinai Health System New York NY USA
  2. 2Icahn School of Medicine at Mount Sinai New York NY USA
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Abstract

Chronic cough, throat clearing, paradoxical vocal fold motion, inducible laryngeal obstruction, and laryngospasm may be secondary to neurogenic laryngeal hypersensitivity (NLH). Patients with these symptoms often score positively on the Newcastle Laryngeal Hypersensitivity Questionnaire (NLHQ), a validated patient‐reported outcome measure designed to assess sensations indicative of NLH. The primary objective of this study was to evaluate the comorbidity of airway stenosis with NLH. A prospective online survey to an airway stenosis support group gathered NLHQ scores in patients diagnosed with airway stenosis. 747 of 946 patients with idiopathic subglottic stenosis (iSGS) (79%) had a clinically positive score on the NLHQ. Patients may clinically benefit from respiratory retraining techniques used in the treatment of NLH. Future studies will examine the relationship between more objective measures of airway size and inflammatory burden with NLHQ scores to determine if the NLHQ is related to/predictive of iSGS severity.

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Cite

BibTeXRIS
BibTeX
@article{laitman2026laryngeal,
  title = {{Laryngeal Hypersensitivity is Correlated With Subglottic Stenosis}},
  author = {Benjamin M. Laitman and Serena Pu and Sandra Jardines and Julia An and Claire Victoria Ong and Leanne Goldberg and Mark Courey},
  journal = {OTO Open},
  year = {2026},
  month = nov,
  doi = {10.1002/oto2.70292},
  url = {https://doi.org/10.1002/oto2.70292},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Laryngeal Hypersensitivity is Correlated With Subglottic Stenosis
AU  - Benjamin M. Laitman
AU  - Serena Pu
AU  - Sandra Jardines
AU  - Julia An
AU  - Claire Victoria Ong
AU  - Leanne Goldberg
AU  - Mark Courey
PY  - 2026
DA  - 2026/11/05
JO  - OTO Open
DO  - 10.1002/oto2.70292
UR  - https://doi.org/10.1002/oto2.70292
AB  - Chronic cough, throat clearing, paradoxical vocal fold motion, inducible laryngeal obstruction, and laryngospasm may be secondary to neurogenic laryngeal hypersensitivity (NLH). Patients with these symptoms often score positively on the Newcastle Laryngeal Hypersensitivity Questionnaire (NLHQ), a validated patient‐reported outcome measure designed to assess sensations indicative of NLH. The primary objective of this study was to evaluate the comorbidity of airway stenosis with NLH. A prospective online survey to an airway stenosis support group gathered NLHQ scores in patients diagnosed with airway stenosis. 747 of 946 patients with idiopathic subglottic stenosis (iSGS) (79%) had a clinically positive score on the NLHQ. Patients may clinically benefit from respiratory retraining techniques used in the treatment of NLH. Future studies will examine the relationship between more objective measures of airway size and inflammatory burden with NLHQ scores to determine if the NLHQ is related to/predictive of iSGS severity.
SN  - 2473-974X
ER  -