Effects of sensorimotor training on chemotherapy-induced peripheral neuropathy-related outcomes in adults with cancer: A systematic review and meta-analysis of randomized controlled trials.
- 1School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
- 2Nursing College, Fujian Medical University, Fuzhou, Fujian, China.
Abstract
Objective
To evaluate the effects of sensorimotor training (SMT)-based interventions on chemotherapy-induced peripheral neuropathy (CIPN) and related outcomes in adults with cancer.Methods
Eleven bibliographic databases and two trial registries were searched from inception to 30 March 2026. Risk of bias was assessed for each outcome using RoB 2, and certainty of evidence was evaluated using GRADE. Meta-analyses used a random-effects model to pool post-intervention data as standardized mean differences (SMDs) with 95% confidence intervals (CIs).Results
Eleven randomized controlled trials were included, with 548 participants randomized to eligible comparison groups; seven contributed quantitative data. Compared with control conditions, SMT-based interventions were associated with better CIPN patient-reported outcomes (SMD = 0.54, 95% CI: 0.18-0.89), clinician-reported outcomes (SMD = 0.50, 95% CI: 0.08-0.92), quality of life (SMD = 0.64, 95% CI: 0.34-0.94), balance function (SMD = 0.79, 95% CI: 0.43-1.15), and lower-limb muscle strength (SMD = 0.67, 95% CI: 0.30-1.04). Interaction tests did not identify statistically significant subgroup differences between SMT alone and combined programs; however, the small number of studies precluded conclusions about comparative or incremental benefit. The certainty of evidence was low for all assessed outcomes.Conclusions
SMT-based interventions may improve CIPN symptoms and related outcomes, but the evidence is limited by small study numbers, risk of bias, heterogeneous populations and protocols, and low certainty. Current evidence is insufficient to determine whether effects differ according to baseline CIPN status or whether adding aerobic and resistance training provides incremental benefit.Systematic review registration
PROSPERO (CRD42024615574).
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BibTeX
@article{lin2026effects,
title = {{Effects of sensorimotor training on chemotherapy-induced peripheral neuropathy-related outcomes in adults with cancer: A systematic review and meta-analysis of randomized controlled trials.}},
author = {Quanping Lin and Lingna You and Liu Yang and Hui Zheng and Kailun Huang and Lixiang Fu and Lingjing Zeng and Yilan Wu},
journal = {Asia-Pacific journal of oncology nursing},
year = {2026},
month = sep,
doi = {10.1016/j.apjon.2026.101034},
url = {https://europepmc.org/article/MED/42904163},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Effects of sensorimotor training on chemotherapy-induced peripheral neuropathy-related outcomes in adults with cancer: A systematic review and meta-analysis of randomized controlled trials.
AU - Quanping Lin
AU - Lingna You
AU - Liu Yang
AU - Hui Zheng
AU - Kailun Huang
AU - Lixiang Fu
AU - Lingjing Zeng
AU - Yilan Wu
PY - 2026
DA - 2026/09/21
JO - Asia-Pacific journal of oncology nursing
DO - 10.1016/j.apjon.2026.101034
UR - https://europepmc.org/article/MED/42904163
AB - Objective To evaluate the effects of sensorimotor training (SMT)-based interventions on chemotherapy-induced peripheral neuropathy (CIPN) and related outcomes in adults with cancer.Methods Eleven bibliographic databases and two trial registries were searched from inception to 30 March 2026. Risk of bias was assessed for each outcome using RoB 2, and certainty of evidence was evaluated using GRADE. Meta-analyses used a random-effects model to pool post-intervention data as standardized mean differences (SMDs) with 95% confidence intervals (CIs).Results Eleven randomized controlled trials were included, with 548 participants randomized to eligible comparison groups; seven contributed quantitative data. Compared with control conditions, SMT-based interventions were associated with better CIPN patient-reported outcomes (SMD = 0.54, 95% CI: 0.18-0.89), clinician-reported outcomes (SMD = 0.50, 95% CI: 0.08-0.92), quality of life (SMD = 0.64, 95% CI: 0.34-0.94), balance function (SMD = 0.79, 95% CI: 0.43-1.15), and lower-limb muscle strength (SMD = 0.67, 95% CI: 0.30-1.04). Interaction tests did not identify statistically significant subgroup differences between SMT alone and combined programs; however, the small number of studies precluded conclusions about comparative or incremental benefit. The certainty of evidence was low for all assessed outcomes.Conclusions SMT-based interventions may improve CIPN symptoms and related outcomes, but the evidence is limited by small study numbers, risk of bias, heterogeneous populations and protocols, and low certainty. Current evidence is insufficient to determine whether effects differ according to baseline CIPN status or whether adding aerobic and resistance training provides incremental benefit.Systematic review registration PROSPERO (CRD42024615574).
SN - 2347-5625
SN - 2349-6673
ER -