Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration
Abstract
Gelatin is a popular biopolymer for biomedical applications due to its harmless impact with a negligible inflammatory response in the host organism. Gelatin interacts with soluble molecules in aqueous media as ionic counterparts such as ionic liquids (ILs) to be used as cosolvents to generate the so-called Ionogels. The perfluorinated IL (FIL), 1-ethyl-3-methylpyridinium perfluorobutanesulfonate, has been selected as co-hydrosolvent for fish gelatin due to its low cytotoxicity and hydrophobicity aprotic polar structure to improve the drug aqueous solubility. A series of FIL/water emulsions with different FIL content and their corresponding shark gelatin/FIL Ionogel has been designed to enhance the drug solubility whilst retaining the mechanical structure and their nanostructure was probed by simultaneous SAXS/WAXS, FTIR and Raman spectroscopy, DSC and rheological experiments. Likewise, the FIL assisted the solubility of the antitumoural Doxorubicin whilst retaining the performing mechanical properties of the drug delivery system network for the drug storage as well as the local administration by a syringe. In addition, the different controlled release mechanisms of two different antitumoral such as Doxorubicin and Mithramycin from two different Ionogels formulations were compared to previous gelatin hydrogels which proved the key structure correlation required to attain specific therapeutic dosages.
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BibTeX
@article{hermidamerino2026ionogels,
title = {{Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration}},
author = {Carolina Hermida-Merino and David Cabaleiro and Carlos Gracia-Fernández and Jesus Valcarcel and José Antonio Vázquez and Noelia Sanz and Martín Pérez-Rodríguez and Maria Arenas-Moreira and Dipanjan Banerjee and Alessandro Longo and Carmen Moya-Lopez and Luis Lugo and Patrice Bourson and Ana Pereiro and Georges Salloum-Abou-Jaoude and Iván Bravo and Manuel Piñeiro and Daniel Hermida-Merino},
journal = {Gels},
year = {2026},
month = sep,
doi = {10.3390/gels8090594},
url = {https://hal.univ-lorraine.fr/hal-03781190v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration
AU - Carolina Hermida-Merino
AU - David Cabaleiro
AU - Carlos Gracia-Fernández
AU - Jesus Valcarcel
AU - José Antonio Vázquez
AU - Noelia Sanz
AU - Martín Pérez-Rodríguez
AU - Maria Arenas-Moreira
AU - Dipanjan Banerjee
AU - Alessandro Longo
AU - Carmen Moya-Lopez
AU - Luis Lugo
AU - Patrice Bourson
AU - Ana Pereiro
AU - Georges Salloum-Abou-Jaoude
AU - Iván Bravo
AU - Manuel Piñeiro
AU - Daniel Hermida-Merino
PY - 2026
DA - 2026/09/02
JO - Gels
DO - 10.3390/gels8090594
UR - https://hal.univ-lorraine.fr/hal-03781190v1
AB - Gelatin is a popular biopolymer for biomedical applications due to its harmless impact with a negligible inflammatory response in the host organism. Gelatin interacts with soluble molecules in aqueous media as ionic counterparts such as ionic liquids (ILs) to be used as cosolvents to generate the so-called Ionogels. The perfluorinated IL (FIL), 1-ethyl-3-methylpyridinium perfluorobutanesulfonate, has been selected as co-hydrosolvent for fish gelatin due to its low cytotoxicity and hydrophobicity aprotic polar structure to improve the drug aqueous solubility. A series of FIL/water emulsions with different FIL content and their corresponding shark gelatin/FIL Ionogel has been designed to enhance the drug solubility whilst retaining the mechanical structure and their nanostructure was probed by simultaneous SAXS/WAXS, FTIR and Raman spectroscopy, DSC and rheological experiments. Likewise, the FIL assisted the solubility of the antitumoural Doxorubicin whilst retaining the performing mechanical properties of the drug delivery system network for the drug storage as well as the local administration by a syringe. In addition, the different controlled release mechanisms of two different antitumoral such as Doxorubicin and Mithramycin from two different Ionogels formulations were compared to previous gelatin hydrogels which proved the key structure correlation required to attain specific therapeutic dosages.
SN - 2310-2861
ER -