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Peer-reviewedLicence not statedNature

Population-scale immune multiome atlas reveals regulatory disease mechanisms

  • Masahiro Kanai1,2,3,4
  • Toni Marie Delorey5
  • Honkanen Jarno6
  • Rodosthenis S. Rodosthenous3
  • Julianna Juvila6
  • Shane Murphy5
  • Isabella Teixeira-Soldano5
  • Hee Seung Hwang5
  • Juha M Karjalainen3,4
  • Jussi Halonen6
  • Georgia Panagiotaropoulou7,1,8,4,9
  • Yuanxiang Zhang7,1,3,8,4,9
88 more authors
  • Cristin Aubin5
  • Eric Chen5
  • コウサク ナンキ1,2,8
  • Toshimi Yoshida1,2,8
  • Kai Liu1,2,8
  • Marla Glean5
  • Nitya Mehrotra5
  • Emily P. Finan5
  • Daniel Chafamo5
  • Yixiao Zhu5
  • Mikko Arvas10
  • Sanni Ruotsalainen3
  • Zhili Zheng7,3,4,9
  • Yoshihiko Tomofuji11,12
  • Daiki Tokuyasu11,13
  • Shinichi Namba11,12
  • Kyuto Sonehara11,12
  • Biobank Japan Project
  • Koichi Matsuda14,15
  • Takayuki Morisaki14,15
  • Natsuhiko Kumasaka15
  • Akiko Nagai14,15
  • Norihiro Harada16
  • Sonoko Harada17,16
  • Yasunobu Nagata18
  • Satoshi Wakita18
  • Hiroki Yamaguchi18
  • FinnGen
  • Mark J. Daly19,20,21,22
  • Pharmaceutical companies
  • Bridget Riley-Gillis23
  • Howard J. Jacob23
  • Coralie Viollet24
  • Slavé Petrovski24
  • Alix Berton25
  • Santha Ramakrishnan25
  • Ellen Tsai26
  • Zhihao Ding27
  • Emily Rose Holzinger28
  • Robert M. Plenge28
  • Joseph Maranville28
  • Mark McCarthy29
  • Rion Pendergrass29
  • Jonathan Davitte30
  • Chia-Yen Chen31
  • Melis Atalar Aksit32
  • Anna Vlahiotis32
  • Katherine Klinger33

60 listed; 100 in total.

33 affiliations
  1. 1Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA
  2. 2Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
  3. 3Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
  4. 4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  5. 5Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  6. 6Blood Service Biobank, Finnish Red Cross Blood Service, Vantaa, Finland
  7. 7Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  8. 8Program in Infectious Disease and Microbiome, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  9. 9Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  10. 10Research and Development, Finnish Red Cross Blood Service, Helsinki, Finland
  11. 11Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  12. 12Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
  13. 13Department of Neurology, Keio University School of Medicine, Tokyo, Japan
  14. 14Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
  15. 15Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  16. 16Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan
  17. 17Atopy (Allergy) Research Center, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan
  18. 18Department of Hematology, Nippon Medical School, Tokyo, Japan
  19. 19Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. [email protected]
  20. 20Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [email protected]
  21. 21Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  22. 22Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  23. 23AbbVie, Chicago, IL, USA
  24. 24AstraZeneca, Cambridge, UK
  25. 25Bayer, Leverkusen, Germany
  26. 26Biogen, Cambridge, MA, USA
  27. 27Boehringer Ingelheim, Ingelheim am Rhein, Germany
  28. 28Bristol Myers Squibb, New York, NY, USA
  29. 29Genentech, San Francisco, CA, USA
  30. 30GlaxoSmithKline, Collegeville, PA, USA
  31. 31Merck, Kenilworth, NJ, USA
  32. 32Pfizer, New York, NY, USA
  33. 33Translational Sciences, Sanofi R&D, Framingham, MA, USA
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Cite

BibTeXRIS
BibTeX
@article{kanai2026populationscale,
  title = {{Population-scale immune multiome atlas reveals regulatory disease mechanisms}},
  author = {Masahiro Kanai and Toni Marie Delorey and Honkanen Jarno and Rodosthenis S. Rodosthenous and Julianna Juvila and Shane Murphy and Isabella Teixeira-Soldano and Hee Seung Hwang and Juha M Karjalainen and Jussi Halonen and Georgia Panagiotaropoulou and Yuanxiang Zhang and Cristin Aubin and Eric Chen and コウサク ナンキ and Toshimi Yoshida and Kai Liu and Marla Glean and Nitya Mehrotra and Emily P. Finan and Daniel Chafamo and Yixiao Zhu and Mikko Arvas and Sanni Ruotsalainen and Zhili Zheng and Yoshihiko Tomofuji and Daiki Tokuyasu and Shinichi Namba and Kyuto Sonehara and Biobank Japan Project and Koichi Matsuda and Takayuki Morisaki and Natsuhiko Kumasaka and Akiko Nagai and Norihiro Harada and Sonoko Harada and Yasunobu Nagata and Satoshi Wakita and Hiroki Yamaguchi and FinnGen and Mark J. Daly and Pharmaceutical companies and Bridget Riley-Gillis and Howard J. Jacob and Coralie Viollet and Slavé Petrovski and Alix Berton and Santha Ramakrishnan and Ellen Tsai and Zhihao Ding and Emily Rose Holzinger and Robert M. Plenge and Joseph Maranville and Mark McCarthy and Rion Pendergrass and Jonathan Davitte and Chia-Yen Chen and Melis Atalar Aksit and Anna Vlahiotis and Katherine Klinger},
  journal = {Nature},
  year = {2026},
  month = sep,
  doi = {10.1038/s41586-026-11078-2},
  url = {https://doi.org/10.1101/2025.11.25.25340489},
}
RIS
TY  - JOUR
TI  - Population-scale immune multiome atlas reveals regulatory disease mechanisms
AU  - Masahiro Kanai
AU  - Toni Marie Delorey
AU  - Honkanen Jarno
AU  - Rodosthenis S. Rodosthenous
AU  - Julianna Juvila
AU  - Shane Murphy
AU  - Isabella Teixeira-Soldano
AU  - Hee Seung Hwang
AU  - Juha M Karjalainen
AU  - Jussi Halonen
AU  - Georgia Panagiotaropoulou
AU  - Yuanxiang Zhang
AU  - Cristin Aubin
AU  - Eric Chen
AU  - コウサク ナンキ
AU  - Toshimi Yoshida
AU  - Kai Liu
AU  - Marla Glean
AU  - Nitya Mehrotra
AU  - Emily P. Finan
AU  - Daniel Chafamo
AU  - Yixiao Zhu
AU  - Mikko Arvas
AU  - Sanni Ruotsalainen
AU  - Zhili Zheng
AU  - Yoshihiko Tomofuji
AU  - Daiki Tokuyasu
AU  - Shinichi Namba
AU  - Kyuto Sonehara
AU  - Biobank Japan Project
AU  - Koichi Matsuda
AU  - Takayuki Morisaki
AU  - Natsuhiko Kumasaka
AU  - Akiko Nagai
AU  - Norihiro Harada
AU  - Sonoko Harada
AU  - Yasunobu Nagata
AU  - Satoshi Wakita
AU  - Hiroki Yamaguchi
AU  - FinnGen
AU  - Mark J. Daly
AU  - Pharmaceutical companies
AU  - Bridget Riley-Gillis
AU  - Howard J. Jacob
AU  - Coralie Viollet
AU  - Slavé Petrovski
AU  - Alix Berton
AU  - Santha Ramakrishnan
AU  - Ellen Tsai
AU  - Zhihao Ding
AU  - Emily Rose Holzinger
AU  - Robert M. Plenge
AU  - Joseph Maranville
AU  - Mark McCarthy
AU  - Rion Pendergrass
AU  - Jonathan Davitte
AU  - Chia-Yen Chen
AU  - Melis Atalar Aksit
AU  - Anna Vlahiotis
AU  - Katherine Klinger
PY  - 2026
DA  - 2026/09/30
JO  - Nature
DO  - 10.1038/s41586-026-11078-2
UR  - https://doi.org/10.1101/2025.11.25.25340489
SN  - 0028-0836
SN  - 1476-4687
ER  -