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Peer-reviewedCC BY-NC-ND 4.0Clinical Case Reports

Vehicle Optimization of Topical Clobetasol Propionate in Disseminated Granuloma Annulare: Clinical Insights From Two Cases

  • Alexandre Raphael Meduri1
  • Giorgia Sbarra1
  • Giulia Ciccarese1
  • Paolo Danza2
  • Vincenzo Scarano3
  • Francesca Ambrogio1
  • William Andrew Rosato1
  • Gerardo Cazzato4
  • Mario Della Mura4
  • Giuseppe Demichele1
  • Caterina Foti1
4 affiliations
  1. 1Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe‐J) University of Bari “Aldo Moro” Bari Italy
  2. 2Interdisciplinary Department of Medicine, Section of Occupational Medicine University of Bari “Aldo Moro” Bari Italy
  3. 3Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology University of Bari “Aldo Moro” Bari Italy
  4. 4Section of Pathology University of Bari “Aldo Moro” Bari Italy
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Abstract

Vehicle composition may influence topical corticosteroid performance. In two patients with disseminated granuloma annulare, switching from clobetasol ointment to the same‐strength solution in diethylene glycol monoethyl ether (DEGEE) was followed by complete clearance, suggesting formulation optimization may be considered when topical treatment provides an inadequate response.

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Cite

BibTeXRIS
BibTeX
@article{meduri2026vehicle,
  title = {{Vehicle Optimization of Topical Clobetasol Propionate in Disseminated Granuloma Annulare: Clinical Insights From Two Cases}},
  author = {Alexandre Raphael Meduri and Giorgia Sbarra and Giulia Ciccarese and Paolo Danza and Vincenzo Scarano and Francesca Ambrogio and William Andrew Rosato and Gerardo Cazzato and Mario Della Mura and Giuseppe Demichele and Caterina Foti},
  journal = {Clinical Case Reports},
  year = {2026},
  month = oct,
  doi = {10.1002/ccr3.73794},
  url = {https://doi.org/10.1002/ccr3.73794},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Vehicle Optimization of Topical Clobetasol Propionate in Disseminated Granuloma Annulare: Clinical Insights From Two Cases
AU  - Alexandre Raphael Meduri
AU  - Giorgia Sbarra
AU  - Giulia Ciccarese
AU  - Paolo Danza
AU  - Vincenzo Scarano
AU  - Francesca Ambrogio
AU  - William Andrew Rosato
AU  - Gerardo Cazzato
AU  - Mario Della Mura
AU  - Giuseppe Demichele
AU  - Caterina Foti
PY  - 2026
DA  - 2026/10/26
JO  - Clinical Case Reports
DO  - 10.1002/ccr3.73794
UR  - https://doi.org/10.1002/ccr3.73794
AB  - Vehicle composition may influence topical corticosteroid performance. In two patients with disseminated granuloma annulare, switching from clobetasol ointment to the same‐strength solution in diethylene glycol monoethyl ether (DEGEE) was followed by complete clearance, suggesting formulation optimization may be considered when topical treatment provides an inadequate response.
SN  - 2050-0904
ER  -