Biofabricated Al₂O₃ nanoparticles as a recyclable heterogeneous catalyst for nicotinonitrile synthesis: antimicrobial activity, molecular docking and ADMET assessment.
7 affiliations
- 1Department of Chemistry, Yashavantrao Chavan Institute of Science, Constituent College of Karmaveer Bhaurao Patil University Satara-415001 Maharashtra India [email protected] [email protected] [email protected] [email protected] [email protected] [email protected].
- 2Department of Chemistry, Shivaji University Kolhapur 416004 Maharashtra India [email protected].
- 3Department of Microbiology, Yashavantrao Chavan Institute of Science, Constituent College of Karmaveer Bhaurao Patil University Satara-415001 Maharashtra India [email protected].
- 4Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to Be University) Karad Maharashtra 415539 India [email protected].
- 5Department of Chemistry, Sadguru Gadage Maharaj College Karad 415124 Maharashtra India [email protected].
- 6Karmaveer Bhaurao Patil University Satara-415001 Maharashtra India.
- 7Department of Chemistry, Georgetown University Washington DC USA.
Abstract
An efficient and environmentally benign Al₂O₃ nanoparticle-catalyzed protocol was developed for the synthesis of nicotinonitrile derivatives under mild reaction conditions using an ethanol-water solvent system. The Al₂O₃ nanoparticles were synthesized via a green approach employing Coccinia indica leaf extract and characterized by XRD, SEM, EDS, FTIR, and BET analyses. The developed catalytic protocol afforded excellent yields (88-96%) within short reaction times (18-40 min), demonstrating a broad substrate scope, high catalytic activity, and excellent recyclability. The synthesized nicotinonitrile derivatives were further evaluated for their antimicrobial activity against S. aureus, B. subtilis, P. aeruginosa, and E. coli, exhibiting promising antibacterial efficacy. Molecular docking studies against the bacterial DNA gyrase B enzyme further supported their potential antimicrobial mechanism, while in silico ADMET analysis indicated favorable drug-likeness and toxicity profiles. Overall, this study demonstrates a sustainable nanocatalytic strategy for the efficient synthesis of biologically active nicotinonitrile derivatives.
Related
- Biofabricated CuO Nanoparticle Reinforced Bamboo Fiber Coatings for Photocatalytic Antimicrobial and Superhydrophobic Biomedical Textile Applications
- Recyclable Synthetic Polymer Nanoparticles for Sustained Target Neutralization
- Magnetic Particle Imaging Reveals Heterogeneous Retention, Leakage, and Redistribution of Nanoparticles Following Intratumoral Injection
- Green Synthesis of Silver Nanoparticles Using Ammoides pusilla Extract: Optimization, Characterization, and Antimicrobial Activity
- Gold Shell-Isolated Nanoparticles Differentially Affect Neutrophil Antimicrobial Function
BibTeX
@article{kokare2026biofabricated,
title = {{Biofabricated Al₂O₃ nanoparticles as a recyclable heterogeneous catalyst for nicotinonitrile synthesis: antimicrobial activity, molecular docking and ADMET assessment.}},
author = {Prakash Kokare and Ashwini More and Nilesh Pandit and Vishvanath Ghanwat and Amol Jadhav and Aniket Sawant and Chaitali Bagade and Dipak Mali and Sunanda Mahanwar and Santosh Kamble},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra06809j},
url = {https://europepmc.org/article/MED/42898952},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Biofabricated Al₂O₃ nanoparticles as a recyclable heterogeneous catalyst for nicotinonitrile synthesis: antimicrobial activity, molecular docking and ADMET assessment.
AU - Prakash Kokare
AU - Ashwini More
AU - Nilesh Pandit
AU - Vishvanath Ghanwat
AU - Amol Jadhav
AU - Aniket Sawant
AU - Chaitali Bagade
AU - Dipak Mali
AU - Sunanda Mahanwar
AU - Santosh Kamble
PY - 2026
DA - 2026/10/19
JO - RSC advances
DO - 10.1039/d6ra06809j
UR - https://europepmc.org/article/MED/42898952
AB - An efficient and environmentally benign Al₂O₃ nanoparticle-catalyzed protocol was developed for the synthesis of nicotinonitrile derivatives under mild reaction conditions using an ethanol-water solvent system. The Al₂O₃ nanoparticles were synthesized via a green approach employing Coccinia indica leaf extract and characterized by XRD, SEM, EDS, FTIR, and BET analyses. The developed catalytic protocol afforded excellent yields (88-96%) within short reaction times (18-40 min), demonstrating a broad substrate scope, high catalytic activity, and excellent recyclability. The synthesized nicotinonitrile derivatives were further evaluated for their antimicrobial activity against S. aureus, B. subtilis, P. aeruginosa, and E. coli, exhibiting promising antibacterial efficacy. Molecular docking studies against the bacterial DNA gyrase B enzyme further supported their potential antimicrobial mechanism, while in silico ADMET analysis indicated favorable drug-likeness and toxicity profiles. Overall, this study demonstrates a sustainable nanocatalytic strategy for the efficient synthesis of biologically active nicotinonitrile derivatives.
SN - 2046-2069
ER -