2026 대한장연구학회 염증성 장질환의 성, 가임력, 임신 및 수유 가이드라인
20 affiliations
- 1이화여자대학교 의과대학 내과학교실
- 2한림대학교 의과대학 강동성심병원 내과학교실
- 3전남대학교 의과대학 내과학교실
- 4한림대학교 의과대학 춘천성심병원 내과학교실
- 5중앙대학교 의과대학 내과학교실
- 6성균관대학교 의과대학 삼성서울병원 내과학교실
- 7대구가톨릭대학교 의과대학 내과학교실
- 8부산대학교 의과대학 내과학교실
- 9부산대학교병원 소화기내과
- 10부산대학교병원 의생명연구원
- 11가톨릭대학교 의과대학 대전성모병원 내과학교실
- 12경북대학교 의과대학 내과학교실
- 13조선대학교 의과대학 내과학교실
- 14가톨릭대학교 의과대학 인천성모병원 내과학교실
- 15연세대학교 의과대학 내과학교실 및 소화기병연구소
- 16울산대학교 의과대학 서울아산병원 소화기내과
- 17고신대학교 의과대학 산부인과학교실
- 18경희대학교 의과대학 강동경희대학교병원 소아청소년과학교실
- 19부산대학교 의과대학 양산부산대학교병원 소아청소년과학교실
- 20연세대학교 원주의과대학 원주의학도서관
Abstract
Inflammatory bowel disease(IBD) is commonly diagnosed during the reproductive years, making sexuality, fertility, pregnancy, and lactation central to long-term care. Misconceptions about heritability, fertility, and medication safety contribute to voluntary childlessness and discontinuation of effective therapy during pregnancy. Accumulating evidence indicates that disease activity, rather than IBD itself or most maintenance therapies, is the major determinant of adverse maternal and fetal outcomes, supporting a paradigm centered on remission before and throughout pregnancy. Meanwhile, newer biologics and small molecules have been incorporated into clinical practice despite limited human reproductive safety data. Uncertainties persist regarding drug continuation, disease monitoring, mode of delivery, breastfeeding, and live vaccination in infants exposed to biologics in utero, highlighting the need for guidance tailored to the Korean national immunization program. The Korean Association for the Study of Intestinal Diseases therefore developed the first guideline in Korea addressing sexuality, fertility, pregnancy, and lactation in patients with IBD. Recent international guidance informed the scope and key questions; however, all evidence was independently reviewed and synthesized, and all recommendations were developed de novo using the GRADE methodology. Given limited randomized trial evidence in pregnancy, evidence synthesis relied primarily on systematic reviews, pregnancy registries, and large cohort studies. Consequently, the certainty of evidence for all recommendations was low or very low. All statements underwent a modified Delphi consensus process. The final guideline comprises 40 statements across 11 chapters: 23 recommendation statements, 9 evidence statements, and 8 expert consensus statements. This guideline supports individualized care throughout the reproductive continuum.
BibTeX
@article{송20262026,
title = {{2026 대한장연구학회 염증성 장질환의 성, 가임력, 임신 및 수유 가이드라인}},
author = {은미 송 and 지영 윤 and 성은 김 and 동현 김 and 영주 양 and 승용 신 and 지은 김 and 준화 배 and 승민 홍 and 상범 강 and 은수 김 and 성중 김 and 준 이 and 수영 나 and 수정 박 and 상형 박 and 한구 윤 and 태형 김 and 연주 이 and 명하 김 and 미영 최 and 원 문 and 성애 정 and 대한장연구학회 가이드라인위원회},
journal = {The Korean Journal of Gastroenterology},
year = {2026},
month = oct,
doi = {10.4166/kjg.2026.094},
url = {https://doi.org/10.4166/kjg.2026.094},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - 2026 대한장연구학회 염증성 장질환의 성, 가임력, 임신 및 수유 가이드라인
AU - 은미 송
AU - 지영 윤
AU - 성은 김
AU - 동현 김
AU - 영주 양
AU - 승용 신
AU - 지은 김
AU - 준화 배
AU - 승민 홍
AU - 상범 강
AU - 은수 김
AU - 성중 김
AU - 준 이
AU - 수영 나
AU - 수정 박
AU - 상형 박
AU - 한구 윤
AU - 태형 김
AU - 연주 이
AU - 명하 김
AU - 미영 최
AU - 원 문
AU - 성애 정
AU - 대한장연구학회 가이드라인위원회
PY - 2026
DA - 2026/10/25
JO - The Korean Journal of Gastroenterology
DO - 10.4166/kjg.2026.094
UR - https://doi.org/10.4166/kjg.2026.094
AB - Inflammatory bowel disease(IBD) is commonly diagnosed during the reproductive years, making sexuality, fertility, pregnancy, and lactation central to long-term care. Misconceptions about heritability, fertility, and medication safety contribute to voluntary childlessness and discontinuation of effective therapy during pregnancy. Accumulating evidence indicates that disease activity, rather than IBD itself or most maintenance therapies, is the major determinant of adverse maternal and fetal outcomes, supporting a paradigm centered on remission before and throughout pregnancy. Meanwhile, newer biologics and small molecules have been incorporated into clinical practice despite limited human reproductive safety data. Uncertainties persist regarding drug continuation, disease monitoring, mode of delivery, breastfeeding, and live vaccination in infants exposed to biologics in utero, highlighting the need for guidance tailored to the Korean national immunization program. The Korean Association for the Study of Intestinal Diseases therefore developed the first guideline in Korea addressing sexuality, fertility, pregnancy, and lactation in patients with IBD. Recent international guidance informed the scope and key questions; however, all evidence was independently reviewed and synthesized, and all recommendations were developed de novo using the GRADE methodology. Given limited randomized trial evidence in pregnancy, evidence synthesis relied primarily on systematic reviews, pregnancy registries, and large cohort studies. Consequently, the certainty of evidence for all recommendations was low or very low. All statements underwent a modified Delphi consensus process. The final guideline comprises 40 statements across 11 chapters: 23 recommendation statements, 9 evidence statements, and 8 expert consensus statements. This guideline supports individualized care throughout the reproductive continuum.
SN - 1598-9992
SN - 2233-6869
ER -