Serum ADAMTS18 Levels at Admission Are Associated With 3-Month Functional Outcome After Acute Ischemic Stroke

Abstract

AIMS: ADAMTS18 is a secreted metalloproteinase implicated in vascular homeostasis and protection against ischemic brain injury. However, its clinical relevance in acute ischemic stroke (AIS) remains unclear. METHODS: We retrospectively analyzed 194 AIS patients from the Chengdu Stroke Registry. Serum ADAMTS18 levels were measured within 48 hours of admission using ELISA. Associations between ADAMTS18 levels and 3-month poor outcomes (modified Rankin Scale score 3-6) were evaluated using logistic regression. Predictive performance was assessed using area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). RESULTS: ＜0.001). Incorporating ADAMTS18 into predictive models improved discrimination (AUC = 0.91 vs. 0.86, P = 0.011), IDI (11.14%, P＜0.001), and NRI (77.1%, P＜0.001). CONCLUSION: Lower admission ADAMTS18 levels are independently associated with poor 3-month functional outcomes after AIS and may provide additional prognostic information.

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BibTeX RIS

BibTeX

@article{cui2026serum,
  title = {{Serum ADAMTS18 Levels at Admission Are Associated With 3-Month Functional Outcome After Acute Ischemic Stroke}},
  author = {Ting Cui and Huan Wang and Yuyi Zhu and Mingxi Chen and Yaqi Chen and Keying Wu and Junfeng Liu and Zilong Hao and Bo Wu and Deren Wang},
  journal = {Journal of Atherosclerosis and Thrombosis},
  year = {2026},
  month = oct,
  doi = {10.5551/jat.66202},
  url = {https://www.jstage.jst.go.jp/article/jat/33/10/33_66202/_article},
  note = {CC BY-NC-SA},
}

RIS

TY  - JOUR
TI  - Serum ADAMTS18 Levels at Admission Are Associated With 3-Month Functional Outcome After Acute Ischemic Stroke
AU  - Ting Cui
AU  - Huan Wang
AU  - Yuyi Zhu
AU  - Mingxi Chen
AU  - Yaqi Chen
AU  - Keying Wu
AU  - Junfeng Liu
AU  - Zilong Hao
AU  - Bo Wu
AU  - Deren Wang
PY  - 2026
DA  - 2026/10/01
JO  - Journal of Atherosclerosis and Thrombosis
DO  - 10.5551/jat.66202
UR  - https://www.jstage.jst.go.jp/article/jat/33/10/33_66202/_article
AB  - AIMS: ADAMTS18 is a secreted metalloproteinase implicated in vascular homeostasis and protection against ischemic brain injury. However, its clinical relevance in acute ischemic stroke (AIS) remains unclear. METHODS: We retrospectively analyzed 194 AIS patients from the Chengdu Stroke Registry. Serum ADAMTS18 levels were measured within 48 hours of admission using ELISA. Associations between ADAMTS18 levels and 3-month poor outcomes (modified Rankin Scale score 3-6) were evaluated using logistic regression. Predictive performance was assessed using area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). RESULTS: ＜0.001). Incorporating ADAMTS18 into predictive models improved discrimination (AUC = 0.91 vs. 0.86, P = 0.011), IDI (11.14%, P＜0.001), and NRI (77.1%, P＜0.001). CONCLUSION: Lower admission ADAMTS18 levels are independently associated with poor 3-month functional outcomes after AIS and may provide additional prognostic information.
SN  - 1880-3873
SN  - 1340-3478
ER  -

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