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PreprintCC BY-NC-NDbioRxiv

Topographical features enhance DNA tetrahedron biostability

  • Sarah Youssef
  • Lauren A. Anderson
  • Mengyao Zheng
  • Arun Richard Chandrasekaran
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Abstract

Stabilization of nucleic acid-based systems is critical for their clinical translation in biomedical applications. Here, we integrated hairpins within the edges of a DNA tetrahedron and studied the stabilization induced by these motifs against nucleases. We show that nuclease resistance of DNA tetrahedra increased with the number of hairpins in the structure, this biostability enhancement is specific to the sequences within the hairpin. Our study provides a new design approach to create nucleic acid nanostructures with inherent biostability.

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Cite

BibTeXRIS
BibTeX
@misc{youssef2026topographical,
  title = {{Topographical features enhance DNA tetrahedron biostability}},
  author = {Sarah Youssef and Lauren A. Anderson and Mengyao Zheng and Arun Richard Chandrasekaran},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.27.762189},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.27.762189v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Topographical features enhance DNA tetrahedron biostability
AU  - Sarah Youssef
AU  - Lauren A. Anderson
AU  - Mengyao Zheng
AU  - Arun Richard Chandrasekaran
PY  - 2026
DA  - 2026/10/27
PB  - bioRxiv
DO  - 10.64898/2026.10.27.762189
UR  - https://www.biorxiv.org/content/10.64898/2026.10.27.762189v1
AB  - Stabilization of nucleic acid-based systems is critical for their clinical translation in biomedical applications. Here, we integrated hairpins within the edges of a DNA tetrahedron and studied the stabilization induced by these motifs against nucleases. We show that nuclease resistance of DNA tetrahedra increased with the number of hairpins in the structure, this biostability enhancement is specific to the sequences within the hairpin. Our study provides a new design approach to create nucleic acid nanostructures with inherent biostability.
SN  - 2692-8205
ER  -