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Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Serial TAPSE and Subsequent 60-Day Mortality Among Critically Ill Adults with Reduced Baseline TAPSE: A MIMIC-IV-ECHO Cohort Study

  • Shanshan Zhai1
  • Dezhi Ren1
  • Yongyi Chen1
  • Hui Wang1
  • Jun Duan1
  1. 1Department of Intensive Care Unit, China-Japan Friendship Hospital, Beijing 100029, China
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Abstract

Background/Objectives: Tricuspid annular plane systolic excursion (TAPSE) is routinely available in critical-care echocardiography, but the prognostic relevance of serial change is uncertain. We examined serial TAPSE and subsequent mortality among critically ill adults with reduced baseline TAPSE. Methods: This retrospective MIMIC-IV-ECHO cohort included adults with at least two TAPSE measurements and baseline TAPSE < 1.7 cm. Serial TAPSE status was classified as improved (increase >0.2 cm) or non-improved (change ≤0.2 cm). Cox regression evaluated 60-day mortality from the follow-up echocardiogram. Results: Among 227 patients, 101 (44.5%) were improved and 126 (55.5%) non-improved over a median interval of 10 days. Non-improved status was associated with higher subsequent mortality (adjusted hazard ratio 1.72, 95% confidence interval 1.06–2.80; p = 0.028). After adjustment for follow-up TAPSE, neither binary status nor continuous change was significantly associated with mortality. Conclusions: In this exploratory study, non-improved serial TAPSE was associated with higher 60-day mortality. Added prognostic value beyond follow-up TAPSE was not demonstrated.

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Cite

BibTeXRIS
BibTeX
@article{zhai2026serial,
  title = {{Serial TAPSE and Subsequent 60-Day Mortality Among Critically Ill Adults with Reduced Baseline TAPSE: A MIMIC-IV-ECHO Cohort Study}},
  author = {Shanshan Zhai and Dezhi Ren and Yongyi Chen and Hui Wang and Jun Duan},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15197753},
  url = {https://www.mdpi.com/2077-0383/15/19/7753},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Serial TAPSE and Subsequent 60-Day Mortality Among Critically Ill Adults with Reduced Baseline TAPSE: A MIMIC-IV-ECHO Cohort Study
AU  - Shanshan Zhai
AU  - Dezhi Ren
AU  - Yongyi Chen
AU  - Hui Wang
AU  - Jun Duan
PY  - 2026
DA  - 2026/10/08
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15197753
UR  - https://www.mdpi.com/2077-0383/15/19/7753
AB  - Background/Objectives: Tricuspid annular plane systolic excursion (TAPSE) is routinely available in critical-care echocardiography, but the prognostic relevance of serial change is uncertain. We examined serial TAPSE and subsequent mortality among critically ill adults with reduced baseline TAPSE. Methods: This retrospective MIMIC-IV-ECHO cohort included adults with at least two TAPSE measurements and baseline TAPSE < 1.7 cm. Serial TAPSE status was classified as improved (increase >0.2 cm) or non-improved (change ≤0.2 cm). Cox regression evaluated 60-day mortality from the follow-up echocardiogram. Results: Among 227 patients, 101 (44.5%) were improved and 126 (55.5%) non-improved over a median interval of 10 days. Non-improved status was associated with higher subsequent mortality (adjusted hazard ratio 1.72, 95% confidence interval 1.06–2.80; p = 0.028). After adjustment for follow-up TAPSE, neither binary status nor continuous change was significantly associated with mortality. Conclusions: In this exploratory study, non-improved serial TAPSE was associated with higher 60-day mortality. Added prognostic value beyond follow-up TAPSE was not demonstrated.
SN  - 2077-0383
ER  -