Metabolic disrupting chemicals in the intestine: the need for biologically relevant models
Abstract
Although the concept of endocrine disruptors first appeared almost 30 years ago, the relatively recent involvement of these substances in the etiology of metabolic pathologies (obesity, diabetes, hepatic steatosis, etc.) has given rise to the concept of Metabolic Disrupting Chemicals (MDCs). Organs such as the liver and adipose tissue have been well studied in the context of metabolic disruption by these substances. The intestine, however, has been relatively unexplored despite its close link with these organs. In vivo models are useful for the study of the effects of MDCs in the intestine and, in addition, allow investigations into interactions with the rest of the organism. In the latter respect, the zebrafish is an animal model which is used increasingly for the characterization of endocrine disruptors and its use as a model for assessing effects on the intestine will, no doubt, expand. This review aims to highlight the importance of the intestine in metabolism and present the zebrafish as a relevant alternative model for investigating the effect of pollutants in the intestine by focusing, in particular, on cytochrome P450 3A (CYP3A), one of the major molecular players in endogenous and MDCs metabolism in the gut.
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BibTeX
@article{erradhouani2026metabolic,
title = {{Metabolic disrupting chemicals in the intestine: the need for biologically relevant models}},
author = {Chedi Erradhouani and Sylvie Bortoli and Selim Aït-Aïssa and Xavier Coumoul and François Brion},
journal = {FEBS Open Bio},
year = {2026},
month = sep,
doi = {10.1002/2211-5463.13878},
url = {https://hal.science/hal-05752210v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Metabolic disrupting chemicals in the intestine: the need for biologically relevant models
AU - Chedi Erradhouani
AU - Sylvie Bortoli
AU - Selim Aït-Aïssa
AU - Xavier Coumoul
AU - François Brion
PY - 2026
DA - 2026/09/16
JO - FEBS Open Bio
DO - 10.1002/2211-5463.13878
UR - https://hal.science/hal-05752210v1
AB - Although the concept of endocrine disruptors first appeared almost 30 years ago, the relatively recent involvement of these substances in the etiology of metabolic pathologies (obesity, diabetes, hepatic steatosis, etc.) has given rise to the concept of Metabolic Disrupting Chemicals (MDCs). Organs such as the liver and adipose tissue have been well studied in the context of metabolic disruption by these substances. The intestine, however, has been relatively unexplored despite its close link with these organs. In vivo models are useful for the study of the effects of MDCs in the intestine and, in addition, allow investigations into interactions with the rest of the organism. In the latter respect, the zebrafish is an animal model which is used increasingly for the characterization of endocrine disruptors and its use as a model for assessing effects on the intestine will, no doubt, expand. This review aims to highlight the importance of the intestine in metabolism and present the zebrafish as a relevant alternative model for investigating the effect of pollutants in the intestine by focusing, in particular, on cytochrome P450 3A (CYP3A), one of the major molecular players in endogenous and MDCs metabolism in the gut.
SN - 2211-5463
SN - 2211-5463
ER -