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Peer-reviewedCC BY-NC 4.0Diabetes, Obesity & Metabolism

Evaluating the Effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) Programme on Type 2 Diabetes Remission

  • Ben Griffiths1
  • Salma Mehar2
  • Marta Blangiardo1
  • Alex Bottle1
  • Shivani Misra3,4
  • Daniel Morganstein5
  • Tony Willis2
  • Edward Gregg1,6
6 affiliations
  1. 1Imperial College London, School of Public Health London UK
  2. 2NHS North West London Collaboration of Clinical Commissioning Groups London UK
  3. 3Division of Metabolism, Digestion and Reproduction Imperial College London London UK
  4. 4Department of Diabetes and Endocrinology Imperial College Healthcare NHS Trust London UK
  5. 5Department of Endocrinology Chelsea and Westminster NHS Foundation Trust London UK
  6. 6Royal College of Surgeons of Ireland University of Medicine and Health Sciences, R.O.I, School of Population Health Dublin Ireland
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Abstract

Aim: To evaluate the real‐world effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) programme, offering total diet replacement or low carbohydrate diet pathways, on weight loss, glycaemic control, glucose‐lowering medication prescribing and remission of Type 2 diabetes.

Materials and Methods: We conducted an observational, pre–post quasi‐experimental analysis using primary care electronic health records from North West London. REWIND participants with ≥ 12 months of follow‐up (n = 1051) were compared with eligible individuals who were not referred to the programme (n = 66 376). Inverse probability weighting was used to adjust for baseline group differences and outcomes estimated as average treatment effects on the treated.

Results: At 12 months, REWIND participation was associated with greater weight loss (−2.1 kg [95% CI: −2.7 to −1.5]), reduced glucose‐lowering medication prescribing (−12.2% [−13.1 to −11.3]) and increased remission (+4.2% [3.9–4.5]) compared with controls, but no significant difference in glycaemic control. The increase in remission was greater among participants following the total diet replacement pathway (+6.9% [6.1–6.8]) than the low‐carbohydrate pathway (+2.9% [2.6–3.2]). Programme completers experienced greater improvements across outcomes, including an +8.1% (7.8%, 8.5%) increase in remission compared with controls.

Conclusions: Participation in REWIND was associated with modest improvements in weight, medication use and diabetes remission compared with usual care. Greater improvements among programme completers suggest that sustaining engagement is an important challenge in achieving benefits from similar programmes in routine care.

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Cite

BibTeXRIS
BibTeX
@article{griffiths2026evaluating,
  title = {{Evaluating the Effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) Programme on Type 2 Diabetes Remission}},
  author = {Ben Griffiths and Salma Mehar and Marta Blangiardo and Alex Bottle and Shivani Misra and Daniel Morganstein and Tony Willis and Edward Gregg},
  journal = {Diabetes, Obesity \& Metabolism},
  year = {2026},
  month = sep,
  doi = {10.1111/dom.71364},
  url = {https://doi.org/10.1111/dom.71364},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Evaluating the Effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) Programme on Type 2 Diabetes Remission
AU  - Ben Griffiths
AU  - Salma Mehar
AU  - Marta Blangiardo
AU  - Alex Bottle
AU  - Shivani Misra
AU  - Daniel Morganstein
AU  - Tony Willis
AU  - Edward Gregg
PY  - 2026
DA  - 2026/09/23
JO  - Diabetes, Obesity & Metabolism
DO  - 10.1111/dom.71364
UR  - https://doi.org/10.1111/dom.71364
AB  - Aim: To evaluate the real‐world effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) programme, offering total diet replacement or low carbohydrate diet pathways, on weight loss, glycaemic control, glucose‐lowering medication prescribing and remission of Type 2 diabetes.  Materials and Methods: We conducted an observational, pre–post quasi‐experimental analysis using primary care electronic health records from North West London. REWIND participants with ≥ 12 months of follow‐up (n = 1051) were compared with eligible individuals who were not referred to the programme (n = 66 376). Inverse probability weighting was used to adjust for baseline group differences and outcomes estimated as average treatment effects on the treated.  Results: At 12 months, REWIND participation was associated with greater weight loss (−2.1 kg [95% CI: −2.7 to −1.5]), reduced glucose‐lowering medication prescribing (−12.2% [−13.1 to −11.3]) and increased remission (+4.2% [3.9–4.5]) compared with controls, but no significant difference in glycaemic control. The increase in remission was greater among participants following the total diet replacement pathway (+6.9% [6.1–6.8]) than the low‐carbohydrate pathway (+2.9% [2.6–3.2]). Programme completers experienced greater improvements across outcomes, including an +8.1% (7.8%, 8.5%) increase in remission compared with controls.  Conclusions: Participation in REWIND was associated with modest improvements in weight, medication use and diabetes remission compared with usual care. Greater improvements among programme completers suggest that sustaining engagement is an important challenge in achieving benefits from similar programmes in routine care.
SN  - 1462-8902
SN  - 1463-1326
ER  -