Integrative Assessment of Teucrium Extracts: Phytochemical Profile, Nutritional-Mineral Composition, Biological Activities, and Toxicological Assessment In Vitro and In Vivo.
7 affiliations
- 1Department of Biology, Faculty of Sciences and Mathematics, University of Montenegro, Podgorica, Montenegro.
- 2Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
- 3Department of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
- 4Faculty of Food Technology, Food Safety and Ecology - University of Donja Gorica, Podgorica, Montenegro.
- 5Department of Chemistry, University of Belgrade-Institute of Chemistry, Technology, and Metallurgy, Belgrade, Serbia.
- 6Field Test D.O.O, Belgrade, Serbia.
- 7Faculty of Technology, University of Montenegro, Podgorica, Montenegro.
Abstract
The qualitative and quantitative analysis of the Teucrium capitatum and Teucrium montanum extracts, assessment of the antioxidant, antimicrobial, and anticancer effects, and in vivo evaluation of acute oral toxicity, were conducted. T. capitatum extract contained higher amounts of flavonoids and phenolic acids than T. montanum extract. Considering the mineral composition, higher concentrations of elements were found in the T. montanum extract compared to the T. capitatum extract. The extract obtained from T. montanum exerted stronger antioxidant and antimicrobial activities than the T. capitatum extract. The ethanolic extract of T. capitatum showed the strongest cytotoxic effects against HeLa, A549, and A375 cancer cell lines, while the T. montanum extract demonstrated weaker cytotoxicity. The extracts triggered apoptosis in HeLa cells. Aqueous extracts did not cause systemic toxicity in Wistar rats. The pharmacological potential of Teucrium extracts rich in phytochemicals and showing antioxidant, cytoprotective, antimicrobial, and cytotoxic effects should be explored in further studies.
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BibTeX
@article{preljevic2026integrative,
title = {{Integrative Assessment of Teucrium Extracts: Phytochemical Profile, Nutritional-Mineral Composition, Biological Activities, and Toxicological Assessment In Vitro and In Vivo.}},
author = {Kenan Preljević and Ivana Pašić and Milorad Vlaović and Svetlana Perović and Slađana Krivokapić and Tatjana Stanojković and Ana Todorović and Katarina Bobić and Dejan Jančić and Milka Jadranin and Gorica Vuković and Andrej Perović and Biljana Damjanović-Vratnica and Ivana Z Matić},
journal = {Chemistry \& biodiversity},
year = {2026},
month = oct,
doi = {10.1002/cbdv.71839},
url = {https://europepmc.org/article/MED/42902909},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Integrative Assessment of Teucrium Extracts: Phytochemical Profile, Nutritional-Mineral Composition, Biological Activities, and Toxicological Assessment In Vitro and In Vivo.
AU - Kenan Preljević
AU - Ivana Pašić
AU - Milorad Vlaović
AU - Svetlana Perović
AU - Slađana Krivokapić
AU - Tatjana Stanojković
AU - Ana Todorović
AU - Katarina Bobić
AU - Dejan Jančić
AU - Milka Jadranin
AU - Gorica Vuković
AU - Andrej Perović
AU - Biljana Damjanović-Vratnica
AU - Ivana Z Matić
PY - 2026
DA - 2026/10/01
JO - Chemistry & biodiversity
DO - 10.1002/cbdv.71839
UR - https://europepmc.org/article/MED/42902909
AB - The qualitative and quantitative analysis of the Teucrium capitatum and Teucrium montanum extracts, assessment of the antioxidant, antimicrobial, and anticancer effects, and in vivo evaluation of acute oral toxicity, were conducted. T. capitatum extract contained higher amounts of flavonoids and phenolic acids than T. montanum extract. Considering the mineral composition, higher concentrations of elements were found in the T. montanum extract compared to the T. capitatum extract. The extract obtained from T. montanum exerted stronger antioxidant and antimicrobial activities than the T. capitatum extract. The ethanolic extract of T. capitatum showed the strongest cytotoxic effects against HeLa, A549, and A375 cancer cell lines, while the T. montanum extract demonstrated weaker cytotoxicity. The extracts triggered apoptosis in HeLa cells. Aqueous extracts did not cause systemic toxicity in Wistar rats. The pharmacological potential of Teucrium extracts rich in phytochemicals and showing antioxidant, cytoprotective, antimicrobial, and cytotoxic effects should be explored in further studies.
SN - 1612-1872
SN - 1612-1880
ER -