Soluble E-selectin and QRISK3-based Cardiovascular Risk Assessment in Women with Polycystic Ovary Syndrome: A Prospective Case-control Study from India.
4 affiliations
- 1Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
- 2Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.
- 3Cardiology, All India Institute of Medical Sciences, New Delhi, India.
- 4National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.
Abstract
Background
Polycystic ovary syndrome (PCOS) is associated with metabolic abnormalities and increased long-term cardiovascular risk. Endothelial dysfunction is considered an early event in atherogenesis, and soluble E-selectin has been proposed as a marker of endothelial activation. However, its role in cardiovascular risk assessment in PCOS remains uncertain.Aim
The study aimed to compare circulating soluble E-selectin levels between women with PCOS and healthy controls and evaluate their association with metabolic parameters and QRISK3-based cardiovascular risk scores.Settings and design
Prospective hospital-based case-control study.Materials and methods
Two hundred women with PCOS diagnosed according to the Rotterdam criteria and 50 age-matched healthy controls aged 18-40 years were enrolled. Clinical assessment, anthropometry, fasting blood glucose, HbA1c, lipid profile, C-reactive protein and soluble E-selectin levels were evaluated. Estimated 10-year cardiovascular risk was calculated using the QRISK3 algorithm.Statistical analysis used
Group comparisons, correlation analyses and multivariable linear regression were performed.Results
Mean soluble E-selectin levels were comparable between women with PCOS and controls (0.61 ± 0.33 vs. 0.61 ± 0.29 ng/mL, P = 0.935). Within the PCOS group, soluble E-selectin correlated positively with HbA1c (r = 0.326, P = 0.001) and fasting blood glucose (r = 0.271, P = 0.001), while no significant associations were observed with anthropometric measures, lipid parameters, blood pressure or QRISK3 scores. In multivariable analysis, fasting blood glucose remained independently associated with soluble E-selectin.Conclusion
Soluble E-selectin levels did not differ between women with PCOS and controls and showed limited associations with cardiovascular risk factors. These findings do not support a major role for soluble E-selectin in cardiovascular risk assessment among young women with PCOS.
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BibTeX
@article{singh2026soluble,
title = {{Soluble E-selectin and QRISK3-based Cardiovascular Risk Assessment in Women with Polycystic Ovary Syndrome: A Prospective Case-control Study from India.}},
author = {Nilanchali Singh and Iman Dandapath and Akanksha Gupta and Surabhi Gupta and Rosemary Jha and Deepti Siddharthan and Ashwani Kumar Mishra and D Kathiravan and Neeta Singh and Zakiya Zakiya},
journal = {Journal of human reproductive sciences},
year = {2026},
month = jul,
doi = {10.4103/jhrs.jhrs_56_26},
url = {https://europepmc.org/article/MED/42924328},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Soluble E-selectin and QRISK3-based Cardiovascular Risk Assessment in Women with Polycystic Ovary Syndrome: A Prospective Case-control Study from India.
AU - Nilanchali Singh
AU - Iman Dandapath
AU - Akanksha Gupta
AU - Surabhi Gupta
AU - Rosemary Jha
AU - Deepti Siddharthan
AU - Ashwani Kumar Mishra
AU - D Kathiravan
AU - Neeta Singh
AU - Zakiya Zakiya
PY - 2026
DA - 2026/07/01
JO - Journal of human reproductive sciences
DO - 10.4103/jhrs.jhrs_56_26
UR - https://europepmc.org/article/MED/42924328
AB - Background Polycystic ovary syndrome (PCOS) is associated with metabolic abnormalities and increased long-term cardiovascular risk. Endothelial dysfunction is considered an early event in atherogenesis, and soluble E-selectin has been proposed as a marker of endothelial activation. However, its role in cardiovascular risk assessment in PCOS remains uncertain.Aim The study aimed to compare circulating soluble E-selectin levels between women with PCOS and healthy controls and evaluate their association with metabolic parameters and QRISK3-based cardiovascular risk scores.Settings and design Prospective hospital-based case-control study.Materials and methods Two hundred women with PCOS diagnosed according to the Rotterdam criteria and 50 age-matched healthy controls aged 18-40 years were enrolled. Clinical assessment, anthropometry, fasting blood glucose, HbA1c, lipid profile, C-reactive protein and soluble E-selectin levels were evaluated. Estimated 10-year cardiovascular risk was calculated using the QRISK3 algorithm.Statistical analysis used Group comparisons, correlation analyses and multivariable linear regression were performed.Results Mean soluble E-selectin levels were comparable between women with PCOS and controls (0.61 ± 0.33 vs. 0.61 ± 0.29 ng/mL, P = 0.935). Within the PCOS group, soluble E-selectin correlated positively with HbA1c (r = 0.326, P = 0.001) and fasting blood glucose (r = 0.271, P = 0.001), while no significant associations were observed with anthropometric measures, lipid parameters, blood pressure or QRISK3 scores. In multivariable analysis, fasting blood glucose remained independently associated with soluble E-selectin.Conclusion Soluble E-selectin levels did not differ between women with PCOS and controls and showed limited associations with cardiovascular risk factors. These findings do not support a major role for soluble E-selectin in cardiovascular risk assessment among young women with PCOS.
SN - 0974-1208
SN - 1998-4766
ER -