Visual Target P3b Amplitude Mediates the Relationship between Childhood Traumatic Experiences and Social Functioning in People at Clinical High Risk for Psychosis

@article{smucny2026visual,
  title = {{Visual Target P3b Amplitude Mediates the Relationship between Childhood Traumatic Experiences and Social Functioning in People at Clinical High Risk for Psychosis}},
  author = {Jason Smucny and Holly K Hamilton and Suzie Lavoie and Thomas J Whitford and Luis Alameda and Öznur Baştürk and Grace R Jacobs and Ines Lepreux and Teya Petrova and Lotta-Katrin Pries and Guilia Trotta and Sandra Vieira and Jean Addington and Sylvain Bouix and Nicholas J K Breitborde and Matthew R Broome and Kristin S Cadenhead and Monica E Calkins and Ricardo E Carrión and Rolando I Castillo-Passi and Jimmy Choi and Philippe Conus and Cheryl M Corcoran and Covadonga M Díaz-Caneja and Lauren M Ellman and Paolo Fusar-Poli and Louise B Glenthøj and Leslie E Horton and Joseph Kambeitz and Tina Kapur and Matcheri S Keshavan and Minah Kim and Sung-Wan Kim and Jun Soo Kwon and Daniel Mamah and Vijay A Mittal and Ofer Pasternak and Godfrey D Pearlson and Jesus Perez and David R Roalf and Jason Schiffman and Jai Shah and Steven M Silverstein and Stefan Smesny and Gregory P Strauss and Judy L Thompson and Daniel H Wolf and Tianhong Zhang and Carrie E Bearden and John M Kane and René S Kahn and Patrick D McGorry and Barnaby Nelson and Martha E Shenton and Scott W Woods and The Accelerating Medicines Partnership Schizophrenia (AMP SCZ) and Gregory A Light and Daniel H Mathalon},
  journal = {Schizophrenia Bulletin Open},
  year = {2026},
  month = oct,
  doi = {10.1093/schizbullopen/sgag041},
  url = {https://doi.org/10.1093/schizbullopen/sgag041},
  note = {CC BY-NC 4.0},
}

TY  - JOUR
TI  - Visual Target P3b Amplitude Mediates the Relationship between Childhood Traumatic Experiences and Social Functioning in People at Clinical High Risk for Psychosis
AU  - Jason Smucny
AU  - Holly K Hamilton
AU  - Suzie Lavoie
AU  - Thomas J Whitford
AU  - Luis Alameda
AU  - Öznur Baştürk
AU  - Grace R Jacobs
AU  - Ines Lepreux
AU  - Teya Petrova
AU  - Lotta-Katrin Pries
AU  - Guilia Trotta
AU  - Sandra Vieira
AU  - Jean Addington
AU  - Sylvain Bouix
AU  - Nicholas J K Breitborde
AU  - Matthew R Broome
AU  - Kristin S Cadenhead
AU  - Monica E Calkins
AU  - Ricardo E Carrión
AU  - Rolando I Castillo-Passi
AU  - Jimmy Choi
AU  - Philippe Conus
AU  - Cheryl M Corcoran
AU  - Covadonga M Díaz-Caneja
AU  - Lauren M Ellman
AU  - Paolo Fusar-Poli
AU  - Louise B Glenthøj
AU  - Leslie E Horton
AU  - Joseph Kambeitz
AU  - Tina Kapur
AU  - Matcheri S Keshavan
AU  - Minah Kim
AU  - Sung-Wan Kim
AU  - Jun Soo Kwon
AU  - Daniel Mamah
AU  - Vijay A Mittal
AU  - Ofer Pasternak
AU  - Godfrey D Pearlson
AU  - Jesus Perez
AU  - David R Roalf
AU  - Jason Schiffman
AU  - Jai Shah
AU  - Steven M Silverstein
AU  - Stefan Smesny
AU  - Gregory P Strauss
AU  - Judy L Thompson
AU  - Daniel H Wolf
AU  - Tianhong Zhang
AU  - Carrie E Bearden
AU  - John M Kane
AU  - René S Kahn
AU  - Patrick D McGorry
AU  - Barnaby Nelson
AU  - Martha E Shenton
AU  - Scott W Woods
AU  - The Accelerating Medicines Partnership Schizophrenia (AMP SCZ)
AU  - Gregory A Light
AU  - Daniel H Mathalon
PY  - 2026
DA  - 2026/10/11
JO  - Schizophrenia Bulletin Open
DO  - 10.1093/schizbullopen/sgag041
UR  - https://doi.org/10.1093/schizbullopen/sgag041
AB  - Background and Hypothesis: Clinical high risk (CHR) for psychosis status is associated with poor social functioning. Previous studies suggest that childhood trauma and reduced amplitude of the P300 event-related potential (ERP) component elicited by infrequent target stimuli (P3b) are associated with poor social function. Here, we examined whether reduced P3b mediates the relationship between reported trauma history and social function in CHR individuals, possibly reflecting the impact of past trauma on neurophysiological processes subserving attention that ultimately influence social functioning.  Study Design: Target P3b ERP amplitudes from visual and auditory oddball tasks acquired at baseline in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) study were analyzed. The mediating effects of auditory and visual P3b amplitude on the relationship between trauma history (Childhood Trauma Questionnaire total score) and Negative Symptom Inventory-Psychosis Risk Asociality (NSI-PR) as well as social functioning (Global Functioning: Social (GFS) scores were examined.  Study Results: Data from 931 CHR participants (average age 21.29 years, 36.3% male) were included in mediation analyses. Visual P3b showed significant (P < .05) mediation of the relationship between trauma load and GFS score (5.4% mediation) as well as mediation of the relationship between trauma history and NSI-PR asociality (9.3% mediation). Auditory P3b did not significantly mediate either relationship.  Conclusions: These results suggest that visual, but not auditory, P3b mediates the relationship between past trauma load and social functioning in CHR, suggesting the effect of trauma on the neurophysiological processes subserving visual target detection may contribute to social functioning deficits in CHR individuals.
SN  - 2632-7899
ER  -