Association Between Circulating PLA2G12B and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study
- 1Department of Geriatric Medicine & Laboratory of Gerontology and Anti-Aging Research, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China
- 2Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China
- 3Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
Abstract
Background: Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes, and dysregulated lipid metabolism contributes to its progression. PLA2G12B is involved in lipid metabolism, yet its subcellular localization and detectability in human serum remain controversial. Clinical evidence regarding the association between circulating PLA2G12B and DKD is still limited.
Aim: To explore the association between circulating PLA2G12B level and the probability of DKD and to perform exploratory analyses of lipid profiles across different disease statuses.
Methods: A total of 230 participants were included in this cross-sectional study. Baseline clinical information, lipid parameters and serum PLA2G12B concentrations were measured. Multivariate logistic regression was applied to explore the association between serum PLA2G12B and DKD. Loess smoothing curves were used to visualize the changing trends, and stratified analyses were performed to evaluate potential interactions.
Results: Elevated circulating PLA2G12B was independently associated with increased possibilities of DKD with a distinct threshold effect. Stratified subgroup analyses confirmed a consistent positive correlation across most subgroups and a significant interaction effect was detected for age tertiles. The trends between PLA2G12B and lipid/insulin resistance/atherogenic parameters across distinct disease stages highlight its stage-dependent role in lipid metabolism of diabetes.
Conclusion: Our study identifies an association between circulating PLA2G12B and DKD among patients with type 2 diabetes. These observational findings provide clues for future research exploring biological pathways relevant to diabetic kidney injury, and further studies are required to characterize the clinical relevance of circulating PLA2G12B.
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BibTeX
@article{yu2026association,
title = {{Association Between Circulating PLA2G12B and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study}},
author = {Xin Yu and Jing Hao and Shanshan Hu and Jiang Zhu and Qian Cai},
journal = {Diabetes, Metabolic Syndrome and Obesity},
year = {2026},
month = oct,
doi = {10.2147/dmso.s631744},
url = {https://doi.org/10.2147/dmso.s631744},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Association Between Circulating PLA2G12B and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study
AU - Xin Yu
AU - Jing Hao
AU - Shanshan Hu
AU - Jiang Zhu
AU - Qian Cai
PY - 2026
DA - 2026/10/30
JO - Diabetes, Metabolic Syndrome and Obesity
DO - 10.2147/dmso.s631744
UR - https://doi.org/10.2147/dmso.s631744
AB - Background: Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes, and dysregulated lipid metabolism contributes to its progression. PLA2G12B is involved in lipid metabolism, yet its subcellular localization and detectability in human serum remain controversial. Clinical evidence regarding the association between circulating PLA2G12B and DKD is still limited. Aim: To explore the association between circulating PLA2G12B level and the probability of DKD and to perform exploratory analyses of lipid profiles across different disease statuses. Methods: A total of 230 participants were included in this cross-sectional study. Baseline clinical information, lipid parameters and serum PLA2G12B concentrations were measured. Multivariate logistic regression was applied to explore the association between serum PLA2G12B and DKD. Loess smoothing curves were used to visualize the changing trends, and stratified analyses were performed to evaluate potential interactions. Results: Elevated circulating PLA2G12B was independently associated with increased possibilities of DKD with a distinct threshold effect. Stratified subgroup analyses confirmed a consistent positive correlation across most subgroups and a significant interaction effect was detected for age tertiles. The trends between PLA2G12B and lipid/insulin resistance/atherogenic parameters across distinct disease stages highlight its stage-dependent role in lipid metabolism of diabetes. Conclusion: Our study identifies an association between circulating PLA2G12B and DKD among patients with type 2 diabetes. These observational findings provide clues for future research exploring biological pathways relevant to diabetic kidney injury, and further studies are required to characterize the clinical relevance of circulating PLA2G12B.
SN - 1178-7007
ER -