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Peer-reviewedCC BY-NC-ND 4.0NPJ Parkinson's Disease

Association of GBA1 status and sex with depression severity and progression in Parkinson’s disease

  • Pierfrancesco Mitrotti1,2
  • Micol Avenali1,2
  • Carlo Alberto Artusi3,4
  • Rosa De Micco5
  • Giulia Giannini6,7
  • Rosaria Calabrese2
  • Luca Gallo1
  • Caterina Galandra2
  • Claudia Ledda3,4
  • Alice Mascia3
  • Mattia Siciliano5,8
  • Francesco Pagliuca5
9 more authors
  • Luisa Sambati6
  • Valeria Sant’Elia5,8
  • Gianfranco Vornetti6,7
  • Giovanna Calandra-Buonaura6,7
  • Leonardo Lopiano3,4
  • Raffaele Lodi6,7
  • Alessandro Tessitore5
  • Marco Bozzali3,4
  • Enza Maria Valente2,9
9 affiliations
  1. 1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
  2. 2IRCCS Mondino Foundation, Pavia, Italy
  3. 3Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy
  4. 4SC Neurologia 2U, AOU Città della Salute e della Scienza, Turin, Italy
  5. 5Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
  6. 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
  7. 7Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy
  8. 8Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy
  9. 9Department of Molecular Medicine, University of Pavia, Pavia, Italy
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Abstract

GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.

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Cite

BibTeXRIS
BibTeX
@article{mitrotti2026association,
  title = {{Association of GBA1 status and sex with depression severity and progression in Parkinson’s disease}},
  author = {Pierfrancesco Mitrotti and Micol Avenali and Carlo Alberto Artusi and Rosa De Micco and Giulia Giannini and Rosaria Calabrese and Luca Gallo and Caterina Galandra and Claudia Ledda and Alice Mascia and Mattia Siciliano and Francesco Pagliuca and Luisa Sambati and Valeria Sant’Elia and Gianfranco Vornetti and Giovanna Calandra-Buonaura and Leonardo Lopiano and Raffaele Lodi and Alessandro Tessitore and Marco Bozzali and Enza Maria Valente},
  journal = {NPJ Parkinson's Disease},
  year = {2026},
  month = jul,
  doi = {10.1038/s41531-026-01460-2},
  url = {https://doi.org/10.1038/s41531-026-01460-2},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Association of GBA1 status and sex with depression severity and progression in Parkinson’s disease
AU  - Pierfrancesco Mitrotti
AU  - Micol Avenali
AU  - Carlo Alberto Artusi
AU  - Rosa De Micco
AU  - Giulia Giannini
AU  - Rosaria Calabrese
AU  - Luca Gallo
AU  - Caterina Galandra
AU  - Claudia Ledda
AU  - Alice Mascia
AU  - Mattia Siciliano
AU  - Francesco Pagliuca
AU  - Luisa Sambati
AU  - Valeria Sant’Elia
AU  - Gianfranco Vornetti
AU  - Giovanna Calandra-Buonaura
AU  - Leonardo Lopiano
AU  - Raffaele Lodi
AU  - Alessandro Tessitore
AU  - Marco Bozzali
AU  - Enza Maria Valente
PY  - 2026
DA  - 2026/07/08
JO  - NPJ Parkinson's Disease
DO  - 10.1038/s41531-026-01460-2
UR  - https://doi.org/10.1038/s41531-026-01460-2
AB  - GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.
SN  - 2373-8057
ER  -