TAPESTRY: an interactive resource for exploring tumor-enriched splice junctions in pediatric brain tumors
Abstract
TAPESTRY (https://tapestry.rokitalab.com) is a database and web application for exploring recurrent tumor-enriched splice junctions (TEJs) in pediatric brain tumors, cancers that carry few protein-coding mutations and therefore few mutation-derived neoantigens. However, TEJs represent a much larger source of neoantigens as potential therapeutic targets in these tumors. TAPESTRY catalogs 45,430 recurrent TEJs across 19 histologies, identified in 1,962 RNA-seq specimens (including 1,272 independent primary tumors) from the Pediatric Brain Tumor Atlas and compared to four normal brain reference cohorts comprising adult, pediatric, developmental and cell-type-resolved tissue. Each junction is classified as tumor-specific or oncofetal; annotated for splice-event type, coding consequence, novelty relative to GENCODE v39 and overlap with Pfam and UniProt protein domains; and scored for recurrence within each histology. Users can search by gene or splicing event and filter results by histology, junction class, and annotation. Users can also generate gene-level expression heatmaps across cohorts, junction-level expression boxplots, and transcript and exon diagrams, and download all tables and figures. A documented REST API supports programmatic access, and all source code is openly available. By making tumor-selective and developmentally reactivated splicing events searchable and interpretable, TAPESTRY supports the prioritization of splice-derived targets for antibody-based, cell-based and vaccine immunotherapies in pediatric brain and central nervous system tumors.
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BibTeX
@misc{sullivan2026tapestry,
title = {{TAPESTRY: an interactive resource for exploring tumor-enriched splice junctions in pediatric brain tumors}},
author = {Patricia J. Sullivan and Ryan J. Corbett and Chao Di and Alex Sickler and Aylar Babaei and Meghali Goswami and Jo Lynne Rokita},
howpublished = {arXiv},
year = {2026},
month = oct,
doi = {10.48550/arxiv.2610.31816},
eprint = {2610.31816},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2610.31816},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - TAPESTRY: an interactive resource for exploring tumor-enriched splice junctions in pediatric brain tumors
AU - Patricia J. Sullivan
AU - Ryan J. Corbett
AU - Chao Di
AU - Alex Sickler
AU - Aylar Babaei
AU - Meghali Goswami
AU - Jo Lynne Rokita
PY - 2026
DA - 2026/10/22
PB - arXiv
DO - 10.48550/arxiv.2610.31816
UR - https://arxiv.org/abs/2610.31816
AB - TAPESTRY (https://tapestry.rokitalab.com) is a database and web application for exploring recurrent tumor-enriched splice junctions (TEJs) in pediatric brain tumors, cancers that carry few protein-coding mutations and therefore few mutation-derived neoantigens. However, TEJs represent a much larger source of neoantigens as potential therapeutic targets in these tumors. TAPESTRY catalogs 45,430 recurrent TEJs across 19 histologies, identified in 1,962 RNA-seq specimens (including 1,272 independent primary tumors) from the Pediatric Brain Tumor Atlas and compared to four normal brain reference cohorts comprising adult, pediatric, developmental and cell-type-resolved tissue. Each junction is classified as tumor-specific or oncofetal; annotated for splice-event type, coding consequence, novelty relative to GENCODE v39 and overlap with Pfam and UniProt protein domains; and scored for recurrence within each histology. Users can search by gene or splicing event and filter results by histology, junction class, and annotation. Users can also generate gene-level expression heatmaps across cohorts, junction-level expression boxplots, and transcript and exon diagrams, and download all tables and figures. A documented REST API supports programmatic access, and all source code is openly available. By making tumor-selective and developmentally reactivated splicing events searchable and interpretable, TAPESTRY supports the prioritization of splice-derived targets for antibody-based, cell-based and vaccine immunotherapies in pediatric brain and central nervous system tumors.
ER -